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Synthesis of oligosaccharides of Dhexosamine type-potential ligands of activating receptors of NK cells
Kovalová, Anna ; Ledvina, Miroslav (advisor) ; Černý, Miloslav (referee) ; Kefurt, Karel (referee) ; Holý, Antonín (referee)
stu(trd oÍgaŮáůr' ďthercce#*' lsťÍees€pd-e fuandffig sibs.. CoNcLusroN In the course of this work, we prepared oligosaccharides containing 2-acetamido-2- deoxyglucopyranose and 2-acetamido-2-deoxygalactopyranose units and tested them for binding to NK cell receptors NKR-p1 and CD69. Branched oligosaccharides are first effective mimetics of natural ligands of CD69. We successfully completed the synthesis despite some challenging problems (multiple glycosylations, H-bonds), and we also obtained results, which contribute to the understanding of a relevant biological question. APLICABILITY AND PERSPECTIVES Although the synthesized o|igosaccharides were speciÍica||y designed as |igands for lectin receptors of NK cells, they may have other uses too. We intend to introduce linkers to the reducing position of the oligosaccharides to enable their presentation on dendrimeric structures. These multiple glycodendrimers can substitute natural multiantenar ligands. Moreover, oligosaccharides of this type might be used as a part of vector systems of new generation targeted combined chemo- and immunotheraoeutics. This Work was suppofted by grants No. 241/2013/B-CH/PřF and 416/2004/B-CH/PřF of GAUK' No. QF31 1 5/2003 of Ministry of Agricutture of cR, 203/00/0071 of Grant Agency of cR, by research project No 24 055 05O6.and...
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