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Mucocutaneous candidiasis and women's sexual hormones
Košťálová, Marie ; Tošner, Jindřich (advisor) ; Kudela, Milan (referee) ; Mencl, Karel (referee)
The aim of this work was to study relationship between mucocutaneous candidiasis (MCC) and women's sexual hormones. This problem is usually solved by dermatologists, gynaecologists and mycologists separately. Our approach is original, because it is primarily based on skin and/or cutaneous appendagies affection and searches for possible coincidence or other relation in vulvovaginal region. We examined 81 women in our study and divided them into two groups according to hormone-level investigation (women in fertile and perimenopausal period, women in postmenopausal period). We also developed "Candida" questionnaire for further anamnestic data correlation. The relationship between MCC and women's sexual hormones was studied both, in vivo and in vitro. We found C. albicans in vagina in both studied groups most frequently at the time of cutaneous candidiasis. In postmenopausal period the incidence of vaginal C. albicans was significantly lower (significantly lower levels of E2, PG). The cultivation identity between skin and vulvovaginal region was more frequent in fertile and perimenopausal period than in postmenopausal one, too. Predominantely concerned C. albicans again, the conformity was considerable in women with established ovulation (significantly higher levels of PG). In presence of C. albicans in...
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Mucocutaneous candidiasis and women's sexual hormones
Košťálová, Marie ; Tošner, Jindřich (advisor) ; Kudela, Milan (referee) ; Mencl, Karel (referee)
The aim of this work was to study relationship between mucocutaneous candidiasis (MCC) and women's sexual hormones. This problem is usually solved by dermatologists, gynaecologists and mycologists separately. Our approach is original, because it is primarily based on skin and/or cutaneous appendagies affection and searches for possible coincidence or other relation in vulvovaginal region. We examined 81 women in our study and divided them into two groups according to hormone-level investigation (women in fertile and perimenopausal period, women in postmenopausal period). We also developed "Candida" questionnaire for further anamnestic data correlation. The relationship between MCC and women's sexual hormones was studied both, in vivo and in vitro. We found C. albicans in vagina in both studied groups most frequently at the time of cutaneous candidiasis. In postmenopausal period the incidence of vaginal C. albicans was significantly lower (significantly lower levels of E2, PG). The cultivation identity between skin and vulvovaginal region was more frequent in fertile and perimenopausal period than in postmenopausal one, too. Predominantely concerned C. albicans again, the conformity was considerable in women with established ovulation (significantly higher levels of PG). In presence of C. albicans in...
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