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The role of cannabinoid receptor 1 in the modulation of nociceptive signaling at spinal cord level
Dresslerová, Denisa ; Špicarová, Diana (advisor) ; Kořínek, Miloslav (referee)
Pain is an integral part of our lives, it warns of possible impending tissue damage and represents a form of protection for the body. Pain can become directly harmful if it persists. It is perceived individually in different intensity, place and length. In most cases, it is a very unpleasant and robust emotional experience. Before pain perception, nociceptive signalling occurs. When a harmful stimulus is detected in peripheral tissues, free nerve endings are activated, the plasma membrane is depolarized and generated action potential convoys to information about the presence of a nociceptive stimulus to the dorsal horn of the spinal cord. The process of nociception includes stimulation of nerve endings, transduction, signal transmission by nerve fibers into the spinal cord, synaptic transmission and conducting an action potential to the brain, where nociceptive signaling is evaluated. An important area for nociceptive modulation is the dorsal horn of the spinal cord, where synaptic transmission occurs between primary and secondary nociceptive neurons. The individual components of the endocannabinoid system play a significant role in the modulation of synaptic transmission. The major cannabinoid receptors are cannabinoid receptors 1 (CB1) and 2 (CB2), and many endocannabinoids also activate...
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