National Repository of Grey Literature 71 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
The use of stem cells in the treatment of Amyotrophic lateral sclerosis
Řehořová, Monika ; Jendelová, Pavla (advisor) ; Klíma, Jiří (referee) ; Jiruška, Přemysl (referee)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by degradation of motoneurons (MN). No effective treatment is currently available. Cellular therapy is considered to be a promising experimental treatment that could target the pathology of complex disease through many potential mechanisms. We compared the effect of three types of repeated applications of human mesenchymal stem cells (hMSC): intrathecal administrations, intramuscular administrations and the combination of these applications. Best results were obtained after combined repeated hMSC administrations. We observed the rescue of MN, neuromuscular junctions and decreasing levels of proteins involved in the signaling of necroptosis (Rip1, cl-casp 8), apoptosis (cl-casp 9) and autophagy (beclin 1), decreasing astrogliosis and the level of astrocytic connexin 43. Neural precursors derived from induced pluripotent stem cells (NP-iPS) are considered as other promising candidates for ALS therapy. Intraspinal administration of NP-iPS increased mRNA expression of BDNF and IGF-1, on the other hand decreased expression of proapoptotic casp 3. We also observed their effect on expression of components of perineural nets (PNN). Human embryonic stem cells (hESC) are the other cell candidates for the treatment of neurodegenerative...
Design of a high-speed electrical machine.
Šolc, Martin ; Klíma, Jiří (referee) ; Mach, Martin (advisor)
This diploma thesis is dedicated to design of highspeed induction motor with power 30 kW, 60 000 rpm. In the beginning of the thesis basic problematic of highspeed motors, used materials and motor types is discussed. The practical part of the thesis concerns design of the motor itself, creating a model in ANSYS Maxwell software, performing several simulations and optimalization of the designed machine. In the last parf of this thesis each simulation is evaluated and the final model of the machine is introduced.
Morphological indications of water activity on Mars
Klíma, Jan ; Kalvoda, Jan (advisor) ; Šobr, Miroslav (referee)
Morphological indications of water activity on Mars Bachelor thesis deals with morphological indications of water activity on the Mars surface. In the papers are summarized and characterized the structures and forms on the surface of planet Mars, which originated in the past by water in gaseous, liquid or solid form. Based on research articles and expert studies, a bachelor thesis has been composed. It provides the summary of shapes on the Mars surface, which were created by water activity. There are many water formed parts of the Martian surface nowadays: valley networks, an extensive basin in the northern hemisphere, which is the remnant of antient ocean, craters lakes in the past, water bound as a solid component of polar caps and many others. The development of water-formed shapes of the Martian surface is described, and these shapes are also located on a brief map. In presented study is elaborated a comprehensive and complex view to morphological indications of the water activity on Mars.
Finite Element Analysis of High Speed Induction Motor With Axially Slitted Rotor
Klíma, Jiří
This paper deals with an analysis of three phase, two pole high speed induction machine with axially slitted solid rotor. The finite element model of induction motor with axial slits has been developed and motor has been analyzed for several slips in order to get performance characteristics. Setting the simulation is crucial and will be discussed. All-important fields and performance characteristics are presented.
Design of Line-start synchronous machine
Lolová, Iveta ; Klíma, Jiří (referee) ; Bárta, Jan (advisor)
This thesis deals with line-start permanent magnet synchronous motor, because in these days the world focuses on energy saving more than ever. Line-start permanent magnet motors represents a possible replacement for asynchronous motors, which are the most used kind of motors and constitute one of the greatest energy consumption apparatuses in the world. The efficiency improvement of induction motors is usually achieved through design optimization of induction motors resulting in limited degrees of success. This thesis also thoroughly explains LSPMSM topology and compares properties of the line-start permanent magnet motors and asynchronous motors. This thesis deals with the design of line-start permanent magnet synchronous motor based on previously designed asynchronous motor. In the last chapter LSPMSM is investigated in RMxprt and Ansys Maxwell.
The Study of Inventory Management in Connection with Manufacturing Process
Tieber, Michael ; Klíma, Jan (referee) ; Jurová, Marie (advisor)
This master’s thesis deals with problems of inventory management in the International Repair Centre for Symbol Technologies Czech Republic s.r.o.. Actual inventory management is described with a focus on materials planning, storage and evidence of inventory movements using information database systems. A part of the thesis is also an analysis of inventory categories from several different aspects. The purpose of the master’s thesis is to submit suitable suggestions of how to improve existing inventory management processes.
Increase of efficiency of a single phase induction machine
Muczka, Vojtěch ; Klíma, Jiří (referee) ; Mach, Martin (advisor)
This thesis is dedicated to efficiency increase of one phase induction machine through material change of induction cage and rotor slot shape optimization under the condition of maintaining the same locked-rotor torque. In the first part of this thesis is the explanation of induction machine principles. Next is the comparison of measured and simulated parameters of small one phase machine from ATAS company. The following part is dedicated to the analysis of rotor slot shape and ring size influence on machine parameters when using pure aluminum instead of resistive alloy. The next chapter deals with slot shape optimization in the program RMxprt, controlled by genetic algorithm written in MATLAB interface. In the final part are the resultant slot shapes simulated in Ansys Maxwell using finite element method and then the measured, simulated and expected parameters are compared.
Line start synchronous machine
Kaczmarczyk, Ruben ; Mach, Martin (referee) ; Klíma, Jiří (advisor)
This work deals with explanation of the construction of a line start synchronous machine. Furthermore, the calculation of the asynchronous machine is made on the basis of the production documentation. The analytical calculation is done in the RMxprt program, then the calculations of both methods are compared. In addition, rotor adjustment of the specified asynchronous motor is performed, including the insertion of permanent magnets into the rotor. Ansys Maxwell program then optimizes and analyzes the engine, and also checks engine's start-up. Finally, the results are compared and summarized.
Analysis of the Lifestyle of University Students
Klíma, Josef ; Muchová, Marta (referee) ; Lepková, Hana (advisor)
The bachelor’s thesis focuses on the analysis of the lifestyle of university students. Considers their habits of the lifestyle, exercising physical activities and the habits of alimentation. Includes some suggestions for improvement. Specifies the theoretical findings of the healthy life-style and compares them with the results of the research among the university students.
Following the phenotype development of TgHD minipigs by invasive and noninvasive approach
Ellederová, Zdeňka ; Baxa, Monika ; Vidinská, Daniela ; Bohuslavová, Božena ; Vochozková, Petra ; Šmatlíková, Petra ; Klíma, Jiří ; Valeková, Ivona ; Ardan, Taras ; Juhás, Štefan ; Juhásová, Jana ; Konvalinková, R. ; Klempíř, J. ; Pokorný, M. ; Krupička, R. ; Kauler, J. ; Hansíková, H. ; Motlík, Jan
Recent promising treatments for Huntington’s disease (HD) may require pre-clinical testing in large animals. In 2009, we generated HD transgenic (TgHD) minipigs with one copy encoding the N-terminal part (548 aa) of human huntingtin (HTT) with 124 CAG/CAA repeats integrated into chromosome 1 q24-q25. The successful germ line transmission occurred through four successive generations.

National Repository of Grey Literature : 71 records found   1 - 10nextend  jump to record:
See also: similar author names
16 KLÍMA, Jan
3 KLÍMA, Josef
2 Klíma, Jakub
16 Klíma, Jan
2 Klíma, Jaromír
3 Klíma, Jaroslav
3 Klíma, Jindřich
8 Klíma, Jiří
3 Klíma, Josef
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