National Repository of Grey Literature 6 records found  Search took 0.01 seconds. 
The role of promyelocytic leukemia protein in genome maintenance
Kindlová, Martina ; Vašicová, Pavla (advisor) ; Kadlečková, Dominika (referee)
Promyelocytic leukemia protein (PML) is a key component for the formation of the PML nuclear bodies (PML−NBs), nonmembrane organelles, in which PML forms a shell surrounding an inner core of this dynamic multiprotein complex. PML is a multifunctional protein that is able to interact with sumoylated proteins and sequestrate them to PML NBs which can work as storage for these proteins or as a platform for biochemical reactions. PML is known for its tumor- suppressive character. However, it can have oncogenic potential under certain conditions which suggests its contradictory role in cancer. PML NBs are highly dynamic structures that undergo structural changes due to the phase of the cell cycle which can physically interact with chromatin. PML NBs maintain genome stability by playing a role during important cellular processes which are regulation of the cell cycle, DNA repair mechanisms, alternative telomere lengthening in cancer cells, or protection of the genome against viral DNA. PML itself can participate in genome maintenance. Concretely, its cytosolic isoform can have a role in inducing apoptosis. The purpose of this section is to provide information about how PML participates in genome stability maintenance and about the possible consequences of the failure of these mechanisms.
The role of promyelocytic leukemia protein in genome maintenance
Kindlová, Martina ; Vašicová, Pavla (advisor) ; Moudrý, Pavel (referee)
Promyelocytic leukemia protein (PML) is a key component for a formation of the PML nuclear bodies (PML−NBs) in which PML forms a shell surrounding an inner core of this dynamic multiprotein komplex. PML may act as a tumor supressor or a regulator of transcription factors. PML-NBs plays a role in the genome stability maintenance by participating in DNA repair including the alternative lenghtening of telomer, regulation of the cell cycle and antivirus protection. The purpose of this section is to provide information about how PML participate in the genome stability maintenance and about possible consequences of failure of these mechanisms.
Entrepreneurship and innovation in congress tourism
KINDLOVÁ, Martina
Diploma work "Entrepreneurship and innovation in congress tourism" is dedicated to analysis of today´s and future economic state of a tennis centre. The tennis centre is part of a capital business company owned by an Austrian having a majority share. Theoretical part defines the term of innovation, characterises tourism and describes its demands, offer and marketing. Practical part analyses concrete economic data of accounting statements by means of horizontal and vertical analyses. Based upon results of this analysis it suggests solution to improving economic prosperity. Investments into enlargement of a hotel part with creating new product packages in the sphere of congress tourism show a solution to this issue.
Penzijní systémy a zkušennost ČR
Kindlová, Martina ; Čermáková, Klára (advisor) ; Brožová, Dagmar (referee)
The subjekt of this bachelor paper is a short description of pension systems in some countries around the Word and pension system in the Czech Republic is described closely. Besides present situation there is also mentioned possible changes of this system according to inspiration from other world economies. I have made extensive calculator for the calculation of optimal high of retirement pension, which is financed by state in a small part and each individual will save alone in a greater part. I have chosen this theme because it is very current and important for its possibly negative economical and cultural effects for today ́s population. At the end I point out that it is necessary to change the pension system, because it is possible that there will not be any money left for pensions, according to the demographic prognosis.
The participation of citizens in the decision processes in connection with the construction of the Prague highway bypass
Kindlová, Martina ; Kadeřábková, Jaroslava (advisor) ; Jílek, Petr (referee)
The topic of this Ba thesis is the set of issues concerning the communication between public sector bodies and the public itself. The first section is focused on the theoretical framework of this subject, as it contains definitions of the basic terms used in civil service communication. The second part of the text deals with a specific construction problem; namely, the construction of the Prague highway bypass in the Praha-Suchdol quarter. Special attention is paid to the participation of citizens in the decision making process, when the issues have direct influence over their daily life and local development. My aim is to outline the way this problem is discoursed with the citizens of Suchdol and which means of influencing the bypass construction are available to them. My thesis is structured so that the theoretical framework from the first part may be applied in this particular case study concerning the Praha-Suchdol quarter.

See also: similar author names
7 KINDLOVÁ, Martina
4 Kindlová, Markéta
4 Kindlová, Michaela
1 Kindlová, Miluše
1 Kindlová, Miroslava
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