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The effect of therapeutical ultrasound and metalic nanoparticles on carcinoma cells
Kalužová, Adéla ; Rozman, Jiří (referee) ; Bernard, Vladan (advisor)
This thesis focuses on the research of an effect of ultrasound and nanoparticles on cancer cells. In the literature search there the applications of ultrasound field in the interaction with aplication of metallic nanoparticles to viability of cancer cells are described, on the basis of in vitro experiments‘ performance. The purpose of metallic nanoparticles‘ application should be a possible reinforcing of its antitumor effect thanks to the presence of ultrasound field. In next part of the literature search there are included the technical performance of devices, their indications and contraindications, parameters of ultrasound fields and application of metallic nanoparticles. The metallic nanoparticles have been becoming a part of the human’s life more and more, that is why it’s necessary to deal with these miniature particles at a higher level. The aim of this thesis is to suggest the ways of resolution based on the principle of sounding of cells with the ultrasound field of suitable parameters and in combination with the application of metallic nanoparticles with a successive performance of the cell viability tests. The viability was determinated by the MTT assay test. Another part of this work is the measurement of parameters of this zone by means of a submersible needle hydrophone, for a better understanding of the ultrasonic zone. In the final part of this work there is necessary the statistical evaluation of the measured data of the experiments carried out and the discussion of the results obtained.
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Evaluation of biosignals and quality assessment of heart assist devices
Kalužová, Adéla ; Vlk,, Daniel (referee) ; Bernard,, Vladan (advisor)
The first part of this bachelor thesis deals with technical problems of apparatuses for heart assistance Heart Mate II LVAD and Levitronix, which are connected with components of apparatuses, parametrs of apparatuses, function of apparatuses, indications and contraindications. In the next part there is description of various biosignals, which are measured according to application of heart support aparatuses. The next aim of this bachelor thesis is suggestion of evalution biosignals, which are monitored and collection of clinical data in which I will statistically evaluated the results and these results will be compared each other and with physiological values. The final aim of this thesis is a reflection of the advantages and disadvantages of the apparatus and discussion.
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Evaluation of biosignals and quality assessment of heart assist devices
Kalužová, Adéla ; Vlk,, Daniel (referee) ; Bernard,, Vladan (advisor)
The first part of this bachelor thesis deals with technical problems of apparatuses for heart assistance Heart Mate II LVAD and Levitronix, which are connected with components of apparatuses, parametrs of apparatuses, function of apparatuses, indications and contraindications. In the next part there is description of various biosignals, which are measured according to application of heart support aparatuses. The next aim of this bachelor thesis is suggestion of evalution biosignals, which are monitored and collection of clinical data in which I will statistically evaluated the results and these results will be compared each other and with physiological values. The final aim of this thesis is a reflection of the advantages and disadvantages of the apparatus and discussion.
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The effect of therapeutical ultrasound and metalic nanoparticles on carcinoma cells
Kalužová, Adéla ; Rozman, Jiří (referee) ; Bernard, Vladan (advisor)
This thesis focuses on the research of an effect of ultrasound and nanoparticles on cancer cells. In the literature search there the applications of ultrasound field in the interaction with aplication of metallic nanoparticles to viability of cancer cells are described, on the basis of in vitro experiments‘ performance. The purpose of metallic nanoparticles‘ application should be a possible reinforcing of its antitumor effect thanks to the presence of ultrasound field. In next part of the literature search there are included the technical performance of devices, their indications and contraindications, parameters of ultrasound fields and application of metallic nanoparticles. The metallic nanoparticles have been becoming a part of the human’s life more and more, that is why it’s necessary to deal with these miniature particles at a higher level. The aim of this thesis is to suggest the ways of resolution based on the principle of sounding of cells with the ultrasound field of suitable parameters and in combination with the application of metallic nanoparticles with a successive performance of the cell viability tests. The viability was determinated by the MTT assay test. Another part of this work is the measurement of parameters of this zone by means of a submersible needle hydrophone, for a better understanding of the ultrasonic zone. In the final part of this work there is necessary the statistical evaluation of the measured data of the experiments carried out and the discussion of the results obtained.
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