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Benzodiazines as compounds with potential bronchodilatory effect
Ježková, Věra ; Špulák, Marcel (advisor) ; Nováková, Veronika (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Věra Ježková Consultant: PharmDr. Marcel Špulák, PhD. Title of Thesis: Benzodiazines as compounds with potential bronchodilatory effect The most active compounds from previous screening contained (piperidine-1-yl)propyl moiety attached to quinazoline or quinoxaline rings. The goal of this project was to introduce hydroxyl into the three-membered carbon linker with a possibility of further modification. The synthesis was carried out employing the reaction of commercially available quinazolinone and racemic epichlorohydrin leading to epoxide which undergoes nucleophilic attack resulting in hydroxyquinazolinones. Similarly, this reaction sequence was applied on quinoxalinone. However, the attempts with sulphur analogue of quinazolinone and quinoxalinone failed. All prepared compounds have been evaluated for their bronchodilatory activity. The results indicated similar level of bronchodilatory effect as their precursors, except one with cyclohexylamine ring, which showed higher bronchodilatory effect.
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Benzodiazines as compounds with potential bronchodilatory effect
Ježková, Věra ; Špulák, Marcel (advisor) ; Nováková, Veronika (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Věra Ježková Consultant: PharmDr. Marcel Špulák, PhD. Title of Thesis: Benzodiazines as compounds with potential bronchodilatory effect The most active compounds from previous screening contained (piperidine-1-yl)propyl moiety attached to quinazoline or quinoxaline rings. The goal of this project was to introduce hydroxyl into the three-membered carbon linker with a possibility of further modification. The synthesis was carried out employing the reaction of commercially available quinazolinone and racemic epichlorohydrin leading to epoxide which undergoes nucleophilic attack resulting in hydroxyquinazolinones. Similarly, this reaction sequence was applied on quinoxalinone. However, the attempts with sulphur analogue of quinazolinone and quinoxalinone failed. All prepared compounds have been evaluated for their bronchodilatory activity. The results indicated similar level of bronchodilatory effect as their precursors, except one with cyclohexylamine ring, which showed higher bronchodilatory effect.
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School Education in Germany
Ježková, Věra ; Walterová, Eliška (advisor) ; Rýdl, Karel (referee) ; Kopp, Botho (referee)
It is the aim of the doctoral thesis to bring new current issue to Czech comparative educational science while using a non-traditional methodological approach and to provide incentives for Czech educational policy. The thesis consists of two main parts: theoretical and methodological part, and research part. In the theoretical and methodological part the aim of the research and research problem are first defined, existing knowledge concerning the topic of thesis are then briefly evaluated, and the the theoretical and methodological bases of the research are presented. The most comprehensive chapter of this part views the presented research from the perspective of the theory on educational research. In the final chapter, the actual execution of the research is briefly described. Powered by TCPDF (www.tcpdf.org)
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Overview of the trade in specimens of rhinoceros
JEŽKOVÁ, Věra
The subject of this thesis was focused on the analysis of international trade with selected specimens of rhino species (trophies, horns, live rhinos, carvings, horn carvings, derivatives) in 2004 - 2013. The trade at the European Union, taking into accounts the position of the Czech Republic, and the global worldwide trade were evaluated in term of importer and exporter and source, purpose and origin of specimens. Evaluation was based on data from the Cites Trade Database which was further processed via contingency tables and graphs. It was found that there was a decrease of import and export in 2013. The most imported specimens were live rhinos in the world (40,5%) and trophies in the European Union, the most exported specimens were trophies in the world (39,4%) and carvings (80,7%) in the European Union. The largest importer was USA in the world (16,6%) and Spain in the European Union (3%). The largest exporter in the world was South Africa (73,9%) and United Kingdom in the European Union (4,6%). The Czech Republic was imported 0,8% of total import and exported 0,2% of total export. Imported specimens came mostly from the wild (62,1%), the country of origin was not completed and were imported mainly as hunting trophies (33,4%). Exported specimens came mostly from the wild (76,3%), the country of origin was not completed (82,2%) and were exported primarily as hunting trophies The results indicate an overall downward trend in the legal trade but also confirm the considerable interest in horns in Asia. Therefore, it is necessary to continue to monitor all transactions.
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