National Repository of Grey Literature 5 records found  Search took 0.01 seconds. 
Synthesis and biological evaluation of novel tacrine-tryptophan derivatives
Jarošová, Michaela ; Opletalová, Veronika (advisor) ; Zitko, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Chemistry and Drug Control Student: Michaela Jarošová Supervisor: Assoc. Prof. RNDr. Veronika Opletalová, Ph.D. Consultant: PharmDr. Jan Korábečný, Ph.D. Title of thesis: Study and biological evaluation of new tacrine-tryptophan derivatives Alzheimer's disease (AD) is a chronic neurodegenerative disease with characteristic histopathological changes in the brain. It is the most common cause of dementia. There is about 7.4 million people affected by AD in Europe today. In connection with aging of the population a significant increase of patients affected by the disease can be expected in the coming years. The cause of neural tissue damage is aggregated amyloid β (Aβ), which disrupts neurons by creating glial hem with consequent inflammatory processes. Hyperphosphorylated τ-protein causes neuronal damage intracellularly by forming so-called neurofibrillary tangles. This leads to macroscopically visible brain atrophy and loss of neurons. Current AD pharmacotherapy is based on influencing the cholinergic system. Acetylcholinesterase inhibitors (AChEIs) - rivastigmine, donepezil and galanthamine are used for this purpose. Memantine, antagonist of N-methyl-D-aspartate receptors (NMDA) has been approved for the...
Consumers and their interest in food composition
JAROŠOVÁ, Michaela
The main purpose of the work is to find out whether the composition of food affects consumers' purchasing decisions or the price is more important to them. At first, important terms related to the issue are explained. The work also explains why food composition is important to check. There may, for example, be situations where food is dangerous. Food safety is provided by supervisory authorities who inform consumers about dangerous foods. Consumer opinions are gathered with help of marketing research using online questionnaires. The obtained data is then analysed and processed through graphs. Based on the results of the analysis, suggestions to improve consumer awareness are made.
Synthesis and biological evaluation of novel tacrine-tryptophan derivatives
Jarošová, Michaela ; Opletalová, Veronika (advisor) ; Zitko, Jan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Chemistry and Drug Control Student: Michaela Jarošová Supervisor: Assoc. Prof. RNDr. Veronika Opletalová, Ph.D. Consultant: PharmDr. Jan Korábečný, Ph.D. Title of thesis: Study and biological evaluation of new tacrine-tryptophan derivatives Alzheimer's disease (AD) is a chronic neurodegenerative disease with characteristic histopathological changes in the brain. It is the most common cause of dementia. There is about 7.4 million people affected by AD in Europe today. In connection with aging of the population a significant increase of patients affected by the disease can be expected in the coming years. The cause of neural tissue damage is aggregated amyloid β (Aβ), which disrupts neurons by creating glial hem with consequent inflammatory processes. Hyperphosphorylated τ-protein causes neuronal damage intracellularly by forming so-called neurofibrillary tangles. This leads to macroscopically visible brain atrophy and loss of neurons. Current AD pharmacotherapy is based on influencing the cholinergic system. Acetylcholinesterase inhibitors (AChEIs) - rivastigmine, donepezil and galanthamine are used for this purpose. Memantine, antagonist of N-methyl-D-aspartate receptors (NMDA) has been approved for the...

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2 JAROŠOVÁ, Magdaléna
1 JAROŠOVÁ, Magdaléna Lucie
18 JAROŠOVÁ, Marie
20 JAROŠOVÁ, Markéta
12 JAROŠOVÁ, Martina
5 JAROŠOVÁ, Michaela
2 Jarošová, Marcela
18 Jarošová, Marie
20 Jarošová, Markéta
12 Jarošová, Martina
1 Jarošová, Milena
1 Jarošová, Miroslava
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