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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Growth hormone - IGF - 1 axis, it's regulation and function. Plasma ghrelin levels in certain pathologic states
 Jarkovská, Zuzana ; Marek, Josef (advisor) ; Hainer, Vojtěch (referee) ; Mareš, Jan (referee)
Ghreliu is a peptide hormone with a strong stimulatory effect on growth hormone (GH) secretion. Ghrelin was origiu;i!íy isolated from the rat stomach as an endogenous secretagogue for the growth hormone secretagogue receptor (GHS-R). Although the fírst coinpoimds of the group of growth hormone seeretagogues were synthesized already in 1997, the isolation of the GHS-R and ghrelin is a matter of tlie last decade. Our study was aimed at the determination of the physiological role of endogenous ghrelin in GH secretion in certain pathological conditions and its associations with tlie GH/IGF-1 axis compounds. Our study was the first one detecíing also active ghrelin coucentrations. We assumed, that ghrelin secretion is aflected by the GH secretory statě. In patíents with acroinegaly we expected low ghrelin coucentrations (hypothesis 1) aud in patients with GHD we presuined, that ghrelin concentrations will be elevated (hypothesis 2) in comparison with healthy subjects as an effect of the negative feedback regulation by GH. Our findings however did not support tliese hypotheses, active and total ghrelin concentrations did not differ between patients and healthy controls. These data do not support an important role tor ghrelin in GH secretion in these conditions as well as the existence of a negative feedback...
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Primary and secondary plant succession in brown coal region of Most
 Jarkovská, Zlata ; Hendrychová, Markéta (advisor) ; Kadlec, Tomáš (referee)
By extraction of mineral resources there are created new spaces, concretely spoil heaps, which are ideal for settlement by new organisms. Based on chosen study areas trajectories of primary and secondary succession have been compared on model group of plants and additionally on aculeata hymenoptera. Research of model groups in primary succession has been conducted on spoil heaps made of substrate from lignite overburden and study of secondary succession has been conducted in foreland and around mines on spontaneously overgrown areas. Difference in number of plant species on individual sampling plots of primary and secondary succession was not significant. Each area in primary succession was not statistically significantlly different in coverage of vegetation from those areas developing under the secondary succestion. Areas of primary and secondary succesion were different in coverage of bare substrate, which more plant species were bound on. Other factors had not statistically significant effect on plant communities and aculeata hymenoptera as well.
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See also: similar author names
2 Jarkovská, Zlata
1 Jarkovská, Zuzana
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