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	Modelling of Radiobiological Mechanisms in Cells and Tissues Hromčíková, Hana ; Lokajíček, Miloš (advisor) ; Barilla, Jiří (referee) ; Judas, Libor (referee) Detailed record
	Modelling of Radiobiological Mechanisms in Cells and Tissues Hromčíková, Hana Title: Modelling of radiobiological mechanisms in cells and tissues Author: Hana Hromcikova Department: Institute of Physics of the ASCR, v. v. i. Supervisor: RNDr. Milos Lokajicek, DrSc. Supervisor's e-mail address: lokaj@fzu.cz Abstract: The probabilistic two-stage model of cell inactivation enables to derive the characteristics of DNA damage induction and repair by an- alyzing published experimental survival data. To analyze in detail the cell inactivation effects of different ions at various energies, damage induction and repair processes in seA^eral hamster and human cell lines have been studied. Published survival data for Chinese hamster CHO- Kl cells and their radiosensitive mutants xrs5 irradiated by carbon ions and normal human nbroblasts irradiated by several light ions have been analyzed using the probabilistic two-stage model. The specialattention is paid to studying the cellular repair processes. The comparison with two common used radiobiological models, the Linear quadratic model and the Local Effect Model, will be presented, too. Keywords: irradiation, damage to DNA, cell survival curves, cell repair, radiobiological model Detailed record
	Modelling of Radiobiological Mechanisms in Cells and Tissues Hromčíková, Hana Title: Modelling of radiobiological mechanisms in cells and tissues Author: Hana Hromcikova Department: Institute of Physics of the ASCR, v. v. i. Supervisor: RNDr. Milos Lokajicek, DrSc. Supervisor's e-mail address: lokaj@fzu.cz Abstract: The probabilistic two-stage model of cell inactivation enables to derive the characteristics of DNA damage induction and repair by an- alyzing published experimental survival data. To analyze in detail the cell inactivation effects of different ions at various energies, damage induction and repair processes in seA^eral hamster and human cell lines have been studied. Published survival data for Chinese hamster CHO- Kl cells and their radiosensitive mutants xrs5 irradiated by carbon ions and normal human nbroblasts irradiated by several light ions have been analyzed using the probabilistic two-stage model. The specialattention is paid to studying the cellular repair processes. The comparison with two common used radiobiological models, the Linear quadratic model and the Local Effect Model, will be presented, too. Keywords: irradiation, damage to DNA, cell survival curves, cell repair, radiobiological model Detailed record
	Modelling of Radiobiological Mechanisms in Cells and Tissues Hromčíková, Hana ; Lokajíček, Miloš (advisor) ; Barilla, Jiří (referee) ; Judas, Libor (referee) Detailed record
	Podrobná analýza odezvy různých buněčných linií na ozařování ionty uhlíku Hromčíková, Hana ; Kundrát, Pavel ; Lokajíček st., Miloš Cell survival data of three Chinese hamster cell lines irradiated by carbon ions have been analyzed on the basis of the probabilistic two-stage model. Detailed characteristics of damage induction and repair-success probabilities have been established, quantifying the difference in response to carbon irradiation between these cell lines. Detailed record

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