National Repository of Grey Literature 114 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Spontaneous Regression of Melanoma in Pigs of the MeLiM Strain
Plánská, Daniela ; Horák, Vratislav (advisor) ; Smetana, Karel (referee) ; Bartůňková, Jiřina (referee)
Melanoma is a skin tumour arising from melanocytes - skin cells bearing pigment melanin. Melanoma belongs among immunogenic tumours, which is probably associated with a relatively high incidence of partial spontaneous regression (SR). Melanoma-bearing Libechov Minipigs (MeLiM) represent a specially bred animal model that is mostly affected by nodular melanomas, which fully regressed in about 2/3 of the affected animals. Our interest was to examine immune response (associated with melanoma cell destruction) and the role of proteins related to the extracellular matrix (reflecting tissue remodeling) during SR of MeLiM melanoma. We performed an extensive time-lapse study of skin melanomas taken from individuals of the MeLiM strain at 3, 4, 6, 8, 10, 12, 20 and 32 weeks (5-10 samples in each age category) in which we immunohistochemically detected the expression of collagen IV, laminin, fibronectin, tenascin C, as well as MMP-2 and we monitored the proportion of basic immune subpopulations in blood and tumour by flow cytometry. The higher expression of collagen IV, laminin and MMP-2 positively correlated with the appearance of melanoma cells. The expression of collagen IV and laminin indicates a possible survival of tumour cells due to the interaction with these proteins, the presence of MMP-2 in these...
Design of the tram tunnel lining
Pokorná, Katka ; Čenčík, Dalibor (referee) ; Horák, Vladislav (advisor)
The subject of the diploma thesis is the design of an alternative variant of the tram tunnel lining on the Large Urban Ring Road in Brno Žabovřesky. The first part of the thesis describes the actually implemented solution. PLAXIS 2D software was used for the alternative design, thanks to which the necessary parameters were obtained. The alternative solution of the primary lining consists of fibre-reinforced shotcrete reinforced with two composite meshes. The proposed alternative was found to be economically more advantageous and, last but not least, less time consuming.
Electro-Magneto-Hydrodynamic Model for Electron Microscopy
Mačák, Martin ; Horák, Vladimír (referee) ; Uruba, Václav (referee) ; Vyroubal, Petr (advisor)
This dissertation thesis deals with the description and development of an electromagneto-hydrodynamic model intended for electron microscopy. The basis of the work lies in the description of characteristic phenomena taking place in electron microscopes with a focus on environmental electron microscopy. The work dealt with a description of the electromagnetic field, supersonic flow of rarefied gas and a motion of relativistic charged particles in a gaseous environment. An electromagnetic model based on the definition of electric and magnetic vector potential was presented and was used for a simulation of an electromagnetic coil. The supersonic flow of a rarefied gas was defined by Navier-Stokes equations. In order to extend their application to low pressures, the boundary conditions for velocity and temperature were modified. Viscosity and thermal conductivity were subsequently introduced as functions of gas pressure. These adjustments were able to describe the effects of lower collision frequency of gas particles. The presented model was used for the analysis of a flow through a separate aperture and a differentially pumped chamber. Furthermore, the model and necessary adjustments for the description of relativistically moving particles were presented. The model was used for the simulation of electron optics. Separate attention was paid to the interaction of charged particles with a gaseous environment. These interactions had a stochastic character and the presented model described both elastic and inelastic collisions. The presented multiphysics model enables the simultaneous simulation of different physical areas and the interactions between them, which leads to a possibility of a more detailed description of processes and to the improvement of environmental electron microscope design.
Preliminary study of the construction of a tram tunnel in Brno
Kuhajdik, Adam ; Janků,, Hynek (referee) ; Horák, Vladislav (advisor)
The selection of a suitable tunneling technology within the territory of the town has an essential impact on behaviour of surrounding buildings. The thesis presents basic applicable methods. The selected method is simulated in a mathematical model whose input parameters are defined according to geotechnical investigation and by calculating from cone penetration test. Furthermore, the thesis deals with parametric comparisons of a constructional element in dimensioning, horizontal and vertical shift of this element and simplified comparison of steel and concrete prices. This thesis also contains re – comparison of construction behaviour within a model with real deformations which are measured using an inclinometer in situ.
Mechanical properties of granitoid rocks of the Moldanubian batholith in the context of a planned deep underground radioactive waste repository
Brabec, Marek ; Horák, Vladislav (referee) ; Krmíček, Lukáš (advisor)
The author of this bachelor thesis carried out a study of the mechanical and physical properties of granites exposed both on Čeřínek hill, which represents the central part of the delineated polygon of the Hrádek site, and in the nearby active Rácov quarry near the village of Růžená. In the theoretical part of the thesis the author describes the geology of the investigated site and the methods used to determine the investigated properties. In the practical part of the thesis the results and outputs obtained from the measurements are mentioned and discused. The practical part of the thesis presents and discuses the results and outputs obtained from field and laboratory measurements.
Rationality of Human Action and Preferences
Horák, Vít ; Sojka, Milan (advisor) ; Mlčoch, Lubomír (referee)
The thesis criticizes the subjectivist-teleological principals of economics. Economics intended to work with the individual preferences without normative, or any other, bias. The neutrality is, however, distorted by deep assumption of the economic thought - the a priori causality between the preferences and action. The teleological perspective as it was introduced by Karel Engliš was sharply delimitated with respect to causality. Neoclassical and Austrian school, however, do mix causality and finality in their conceptions of action and preferences. My thesis strives to describe this mistake. It is also possible to formulate the theme of the thesis as criticism of the assumption of certain a priori rationality of human action. I try to clear up the notion of rationality, show the possibilities of its meaning and point out at the radicalism of any assumed causality it may encompass. I use the critical conclusions to outline a preference framework that would not repeat the identified mistakes, which would, however, set out from the subjectivist-teleological perspective as well.
Purpose and rationality in the theory of action: Max Weber, Talcott Parsons and an outline of an alternative
Horák, Vít ; Balon, Jan (advisor) ; Urban, Jan (referee)
Submitted thesis examines the role of the notion of end (purpose) in the theory of action and how reaching an end can be considered as rational. Underlying motive is an intuition of the Frankfurt school that identified modern society as irationally rational. By supplementing the notion of end with a dimension of its latitude - the spectrum of possibilities that are open for an action - I try to diferentiate it and enable a multi-dimensional conception of purposeful action in which creative and reactive aspects of an action can be separated. Inside this conception I try to make the abovementioned oxymóron intelligible without relying on moral maxims to which would be the action subordinated. To the this goal I progress from a discussion of the hermeneutical metatheoretical principles through a critical analysis of Weber's and Parsons' theory of action. I go through Weber's concept of understanding (verstehende) sociology, the question of access into the perspective of others, the notion of meaning (purpose), end, and rationality and Parsons' discussion of the possibilitties of analytical theory in sociology and the concept of "unit act".
Worcamp Liminality, or There and Back Again (and the extraordinary experiences that happen in between)
Sedláčková, Tereza ; Grygar, Jakub (advisor) ; Horák, Vít (referee)
Bachelor thesis "Workcamp Liminality, or There and Back Again (and the extraordinary experiences that happen in between)" deals with initiation in contemporary society. It elaborates on initiation of transition between childhood and adulthood, which is made possible through the secular rituals of transition. A research on one workcamp is used to analyse this type of initiation. Three-phase concept rites de passage of Arnold van Gennep, focusing on the middle, liminal, stage and its course as described by Victor Turner is used in the analysis. The aim of this paper is to outline some examples of travelling, which may take the form of rites de passage, and through research on one specific workcamp show that it is possible to encounter the liminal and initiating characteristics of travelling there. According to the theories of Victor Turner emergence of communitas is perhaps the clearest indication of liminal stage (or rite de passage and initiation). Turner's understanding of communitas is very important especially for the empirical part of the text. Methodological work is based on participant observation in the field and semi-structured interviews with workcamp participants conducted during the workcamp. This work shows that under specific circumstances, the workcamp environment can facilitate...

National Repository of Grey Literature : 114 records found   1 - 10nextend  jump to record:
See also: similar author names
1 Horák, Vladimír
4 Horák, Vojtěch
3 Horák, Vratislav
13 Horák, Václav
9 Horák, Vít
3 Horák, Vítězslav
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