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Modeling Sound Field in Closed Space at Low Frequencies
Hořák, Pavel ; Kiska, Tomáš (referee) ; Schimmel, Jiří (advisor)
This diploma thesis deals with issues of low frequency acoustics and simulation. In this work the FTDT method of simulation is used. Measuring and simulation are focused on live-sound system and are evaluated using basic sound system optimisation techniques. Main output of this work is verification of basic low-frequency acoustics principles using simulation and measuring.
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Credit Limit Management and Credit Application
Horák, Pavel ; Hebelka, Ivo (referee) ; Zeman, Václav (advisor)
The thesis deals with the bank credit risk over enterpreneurial subject with double-entry accounting system. The monitoring of possibilities to acquire the bank credit for future business development is based on operating results. The requisition for the bank credit is being prepared also with for the component for the bank providing the credit.
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Measurement of the reverberation time
Hořák, Pavel ; Ryndová, Anna (referee) ; Jedelský, Jan (advisor)
This bachelor thesis deals with issues concerning measuring of reverberation time in closed rooms. Two evaluation methods are described in this thesis; integrated impulse response method and interrupted noise method. Data were recorded with the aid of acoustic module Photon+ and RT Pro 7.1. software. Practical part comprises implementation of evaluation programme in Matlab environment. Computation of reverberation curves is a major output of the thesis. Individual methods are compared on the basis of discovered figures.
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Reporting of the Selected Company
Drábková, Adéla ; Horák, Pavel (referee) ; Hanušová, Helena (advisor)
The thesis deals with reporting. The first part is theoretically explained the concept of reporting, as one of the basic functions of controlling, PEST analysis, Porter's five forces model, 7S analysis and SWOT analysis. The practical part is focused on the analysis of the situation in reporting and follow-up proposals to improve the situation.
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Václav Majer and the Social Democratic Party. The Fortunes of the Leading Figure of One Stream within the Czechoslovak Social Democracy
Brož, Jan ; Kocian, Jiří (advisor) ; Zahradníček, Tomáš (referee) ; Horák, Pavel (referee)
The present thesis deals with the political career of a Social Democratic politician Václav Majer. No specialized paper has so far been dedicated to his fifty-year-lasting career, even though his position in history of the Czechoslovak Social Democratic Party is far from negligible. Václav Majer is particularly known as a leader of the "right"/anti-communist wing within the Social Democratic Party during a short spell of Czechoslovak history from 1945 to 1948 (so-called Third Republic). However, he had started his career much earlier at the beginning of the First Czechoslovak Republic in Louny District. In mid-thirties he had moved to Prague and kept on working after the Munich Agreement was signed, and during the Protectorate as well. At the beginning of 1940 he emigrated to the United Kingdom. During the Second World War he has started his career in high level exile politics in London. After the Communist coup d'état in 1948, which had ended the period of the Third Republic, Majer left Czechoslovakia again. He lived and worked in exile till his death. Attention is paid to Majer's position on political scene and to development of his relations with other political actors. My research is based on study of archival documents, as well as study of specialized books, memoirs, newspapers and periodicals.
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Pathophysiological and genetic factors affecting serum uric acid level.
Hasíková, Lenka ; Závada, Jakub (advisor) ; Hrnčíř, Zbyněk (referee) ; Horák, Pavel (referee)
Introduction: Serum uric acid level (SUA) depends on the balance between its production and excretion. SUA is associated with several transmembrane proteins responsible for reabsorption (mainly URAT1 and GLUT9) and secretion (ABCG2) on the apical and basolateral membranes of the proximal tubules in the kidney, and in the case of ABCG2, it also correlates with its significant excretion through the gastrointestinal tract. Gout is a metabolic disease caused by the deposition of urate crystals in the joints and tissues. Chronic hyperuricemia is a primary risk factor for the development of gout; however, gout patients usually have a lower SUA during an acute gout attack than in the intercritical periods. The exact mechanism of this phenomenon is unknown. It has been speculated that the systemic inflammatory response can explain this discrepancy. The aim of the study is to determine whether treatment with specific inhibitors of the proinflammatory cytokine TNF (TNFi) affects SUA in patients with systemic rheumatic disease (SRD), and whether changes in SUA correlate with changes in selected proinflammatory cytokines or with the biomarker of oxidative stress, allantoin. Another aim is to determine the frequency and effect of allelic variants in the ABCG2 urate transporter gene in patients with primary...
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The Effect of Selected Drugs on Bone Metabolism
Karešová, Iva ; Palička, Vladimír (advisor) ; Bayer, Milan (referee) ; Horák, Pavel (referee)
With an aging population and increasing life expectancy, osteoporosis represents a major global health problem. Currently it is estimated that more than 200 million people suffer from osteoporosis. Fractures due to osteoporosis are the major cause of morbidity and mortality in the elderly (Compston et al., 2019). A large body of evidence suggests an association between AEDs and bone abnormalities. The prevalence of osteoporosis and osteopenia in long-term treated epileptics is high. More than 50% of patients with epilepsy have low bone mineral density (BMD) (Ko et al., 2020). The aim of the dissertation was to evaluate the effect of orchidectomy and the effect of selected new antiepileptic drugs (zonisamide, gabapentin, pregabalin, levetiracetam) on bone metabolism in young Wistar rats. The negative effect on bone tissue after rat orchidectomy was confirmed after 12 weeks. Orchidectomy led to a statistically significant reduction in BMD and had a negative effect on the biomechanical properties of bones. Our results confirm that young rats after orchidectomy can be considered a suitable animal model for the study of osteopenia. After 12 weeks of administration of new antiepileptic drugs (zonisamide, gabapentin, pregabalin, levetiracetam), there was no statistically significant effect on BMD in...
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Dietary measures in gastroesophageal reflux disease
Thiel, Simona ; Maruna, Pavel (advisor) ; Horák, Pavel (referee)
The bachelor thesis focuses on dietary measures in gastroesophageal reflux disease. The main aim was to investigate the adherence to recommended dietary measures aimed at reducing the frequency of unpleasant symptoms accompanying this disease. In some cases, dietary measures may help to completely eliminate the symptoms. The hypothesis is that patients with reflux disease do not adhere to these measures. A secondary aim was to test the effectiveness of dietary measures in patients who faithfully follow them. By means of a questionnaire survey, a total of 33 patients were asked primarily about their adherence to dietary and regimen measures, as well as about the nature of their complaints and the level of their quality of life. The results show that almost 70% of patients do not currently follow any dietary measures. On the contrary, patients following a diet showed an improvement in symptoms (reduction in the number of reflux episodes), and some individuals even had no symptoms. Finally, some recommendations that may contribute to the improvement of this issue are described. Keywords: Gastroesophageal Reflux Disease, Dietary Measures, Nutrition, Proton Pump Inhibitors
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