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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Thoracoscopic chemically induced pleurodesis in the treatment of malignant pleural effusion as a model of general and local inflammatory reaction
 Habal, Petr ; Manďák, Jiří (advisor) ; Schützner, Jan (referee) ; Odrážka, Karel (referee)
Thoracoscopic chemically induced pleurodesis in the treatment of malignant pleural effusion as a model of general and local inflammatory reaction Petr Habal Summary Continuous formation of malignant pleural effusions causes metabolic and mineral disruption. Large effusions gradually compress the lung parenchyma. The result is an increasing shortness of breath. Prolonged compression of pulmonary parenchyma also causes atelaktasis which may then cause an inflammatory process of the lung parenchyma. An effective method of palliative treatment is a chemical pleurodesis, which is used in selected patients as a second line of palliative cancer treatment. The principle is to eliminate the space between the visceral and parietal sheets of pleura by inducing aseptic inflammation. The most effective way of application of chemicals is via videothoracoscopy. The advantage is the possibility of drainage of pleural cavity and application of talc powder. Pleurodesis has been used for many years, but there is a lack of objective assessment of the overall and local inflammatory reactions, by which the body responds to foreign substances. In a group of 47 patients who were treated at our department in the period between January 2009 and December 2010, 29 (61.7%) were men and 18 (38.3%) were women with a cytologically proven...
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