National Repository of Grey Literature 26 records found  previous11 - 20next  jump to record: Search took 0.00 seconds. 
The role of microRNAs in chronic lymphocytic leukemia
Moravec, Martin ; Macůrková, Marie (referee) ; Hájek, Miroslav (advisor)
2 Abstract MicroRNAs (miRs, miRNAs) are recently discovered molecules (19-25 nucleotides long) that regulate gene expression at post-transcriptional level by either blocking protein synthesis or mRNA degradation. As a part of gene silencing mechanism, miRNAs are involved in cellular processes, such as apoptosis, cell proliferation, development and viral defence. miRNAs have been intensely studied in connection to disease pathogenesis. Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries affecting mostly elderly people. In my work I focus on explanation of miRNA functions and their contributions to chronic lymphocytic leukemia (CLL). I describe previously published data about miRNA-15, miRNA-16, miRNA-143, miRNA-145 and miRNA-155 in connection to this disease. Based on recent reports, I also discuss the potential role of miRNA-326 in CLL pathogenesis.
Management of textile waste from housholds in Czech Republic
Nencková, Lucie ; Hadrabová, Alena (advisor) ; Lisa, Aleš (referee) ; Hájek, Miroslav (referee)
Proper consumer attitude towards textile products and optimal post-consumer waste management of textile waste is connected with many benefits. Despite this fact, little research has been conducted on these topics. Textile waste represented mainly by donated textile from households and its material flow in waste streams mirrors the behaviour of our consumer society as well as new technologies in textile and fashion industry. More information about consumer attitude and behaviour toward textile and textile waste is needed to provide suitable waste management processes according to the hierarchy of waste management, such as re-use and energy recovery, and to ensure sustainable development and minimal impact on the worlds wellbeing. This study takes into account not only waste management of textile waste, but also tries to understand all textile issues in a wider perspective. Particularly fashion industry is connected with many negative ethical aspects (e.g. sweatshops), and many environmental issues are connected with overproduction of lower-quality textile products. Proper handling of post-consumer textile products is only one of the product life cycle stages to be solved. The main goal of this study is to discuss the results of a consumer attitude and behaviour questionnaire toward textile and textile waste from households in the Czech Republic. The study also includes partial hypotheses and an analysis of interest groups as other possible sources of information to form proper textile waste management policy tools and strategies.
Assessment of Policy Changes of the Impacts of Urbanization, Economic Growth and Decentralization of Water Services with Regard to Water Quality in Mexico
Lara Cervantes, René Fernando ; Šauer, Petr (advisor) ; Dvořák, Antonín (referee) ; Hájek, Miroslav (referee)
The thesis studies the case of water quality in Mexico as a crucial factor to prevent water scarcity. This is an important issue for Mexico since more than half of its territory is arid or semi-arid; moreover, the most productive regions are located in areas with significant water resources stress. In this regard, the current situation of water scarcity is studied from the changes in water management derived from the evolution of institutions in the country. The institutional changes were analyzed mostly in the transition from a centralized water supply and sanitation services with strong state intervention to the decentralization of such services that were transferred to municipalities. Decentralization was addressed by analyzing the performance of water supply and sanitation services in urban areas that are expected to continue growing in the near future. The literature shows that the decentralization process has been partial and has not improved as expected the performance of water supply and sanitation services, moreover, due to political reasons, limited human and financial resources it introduced more challenges to the accomplishment of sustainable water management. More importantly, the federal government is still the main agent for the development of the water sector in Mexico. The next part of the analysis consist of a quantitative and qualitative evaluation regarding water quality for the three most productive Hydrological-Administrative Regions (HARs) of Mexico in the period of 2003-2013. The HARs chosen are the HAR VI Río Bravo, HAR VIII Lerma Santiago Pacific and HAR XIII Waters of the Valley of Mexico which are very similar in terms GDP share and water stress degree. Through OLS regression models for each HAR the impacts of demographic, economic, water supply and sanitation services aspects were tested to known their effects on water quality. In order to improve the discussion of the results, additional to the comparison with the results of the literature review, three experts were asked to answer a questionnaire about the regressions outcome. The discussion showed different impacts of the independent variables in the dependent variable of each HAR, sometimes leading to unexpected results. The main conclusions of the thesis relate to the improvement of decentralization of water and sanitation services, to the need to improve data for future analyses and pay more attention to water quality issues. In this regard, decentralization requires to consider contextual differences in order to seize its advantages to improve the performances of water supply and sanitation services, moreover, at the operative level water management decisions must be taken without political interests involved. The statistical analyses stressed the need to develop more reliable data about water management issues to improve the understanding of factors that could potentially affect water quality. In this regard, the creation of useful statistical indicators to assess the evolution towards sustainability in water management. The considerations for future research must consider more seriously water quality issues. This topic has been often ignored, however, it is crucial for water scarcity abatement.
Analysis of Organizational Arrangement of Environmental Protection
Lípa, Jan ; Hájek, Miroslav (advisor) ; Hrib, Michal (referee)
The paper deals with the current form of organizational arrangement of environmental protection in the City of Prague at the level of districts, administrative wards and municipality. It assesses the effectiveness of organizational arrangement and shows disunity of organizational structure. Describes the process of decision making. The paper finds unsatisfactory state, which, however, no one has addressed so far. It analyzes possible solutions and presents options of optimal solution and approach consisting in a reduction of municipalities themselves within the reform of public administration, or in a transfer of execution of public administration to a higher level -- i.e. the administrative ward. It also deals with a number of other related issues, such as administrative workload of staff members and proposes, among other things, to desist from not necessary activities. The text does not assess directly the actual economic effectiveness of the work, for which much more data would be required.
Implementation of the Social Pillar as Part of a Strategy for Sustainable Development of the Company
Mikulková, Andrea ; Hájek, Miroslav (advisor) ; Stanislav, Stanislav (referee)
This dissertation deals with the issue of sustainable development at the corporate level. Attention is focused mainly on social pillar and its internal area, it means to employees. The author sees employees as being one of the key factors of a successful business. In the first part we are given fundamental theoretical basis, through the analysis of documents, passing slowly by sustainable development in general, to the actual social pillar at the corporate level, as well as its most famous appearance in the concept of Corporate Social Responsibility (CSR). Given the focus on the practical part, the theory part will be devoted to the idea of sustainable development in forestry companies, with the assistance of acceptance forest management certification PEFC (Programme for the Endorsement of Forest Certification schemes).
Efficiency valuation of multiple-use forestry
Ševčík, Michal ; Hájek, Miroslav (advisor) ; Martin, Martin (referee)
The thesis outlines the facts that the multi-use forest management and evaluation of its efficiency is a difficult, continual discipline which covers greater amount of knowledge through various fields of science. The thesis tries to prove (suggests) that the forestlands are irreplaceable in performing other functions- economic, social and environmental functions in particular. The thesis deals with effective suggestions how to value these underrated effects and to find out if their production is efficient. It also explores whether a forest manager can monitor and make decisions on the basis of implementation of environmental accounting. The application of a reporting scheme, developed by the "Global reporting initiative", should be the climax of a corporate management. Moreover, this tool offers a suitable methodic software which can be used by the management to inform stakeholders. Eventually, stakeholders can use reports to evaluate the efficiency of corporate forest management, particularly in the field of non-productive forest functions. The thesis deal with three firm to identify scope nonproduction function brings. The thesis deal with development of equation used in financial analysis or methods used for qualitative measurement, commonly used in other industries. The amount of cost and revenues assumed from research will be used for evalaution of total rate of efficiency in forest company.
Horse hauling analysis
Bendová, Gabriela ; Hájek, Miroslav (advisor) ; Štícha, Václav (referee)
The aim of this study was to analyze the work horse covering the technical and economic aspects in the Giant Mountain National Park zoning department 34 Black Mine and capture cost analyzes horse blanket, I know him from his experiences in the period from 2011 to 2012. Thus, from the very start, which means setting up for the coachman, stables, horse paddock, recording facility, registry horses and the establishment of a trade license. Briefly described the driver duties in irrigate the horses, which is his duty throughout the year. Regardless of his health status and climatic conditions. These duties involve the surrounding work like collecting manure, building corrals and care for the wellbeing of animals. Acquisition horse unit plays an important role for the driver must choose correctly and the horse be good companion, as they had to in this difficult craft absolutely believe, so in order to prevent possible undesirable situations. You will see two different types of horses, which can be used in mountainous areas with their price. Another part is the economic analysis and describing the necessary tools to clean wood and horse harnesses. It calculated fixed costs for the two horses in one year. According to the accounting records of the costing and earnings for the five years of business operation and only in the period of active business license. Evaluation skidding horses took place on the ground in the territory of KRNAP, workplace Department 505, 509, 510, 519 and 525 in the spring of 8.4. to 5.15 2014. wood- clean Lukas Benda horse Karina and Ferda.
Design and implementation of an environmental management system at forest property
Marek, Filip ; Dudík, Roman (advisor) ; Hájek, Miroslav (referee)
The aim of this thesis is to describe the ISO 14001 implementation process. The analysis of selected sources was used to make the implementation model, which was verified on selected forest management propertie then. The ready made aspect register containing their identifications and evaluation is annexed.
Technical and economic analysis of selected small sawmill
Maleček, Dušan ; Hájek, Miroslav (advisor) ; Barbora, Barbora (referee)
Bachelor thesis evaluates the technological base of existing small sawmill, according to the monitoring of wood processing activities and business results, during the reporting period. Thesis is primary divided into two parts. First one evaluates technological base, depending on the age and condition of machines, princeples of wood processing and so on. Second one evaluates technological base, depending on the changing trends in the management of the company. The second section also outlines the financial possibilities in the context of potential investments and informs about health of the company. In the end of this thesis, there are also conclusions of above-mentioned parts and ideas about improving of current technological base.
Evaluation of current company´s information system and change suggestions.
Hájek, Miroslav ; Krejča, Zdeněk (referee) ; Neuwirth, Bernard (advisor)
Bachelor's thesis deals with analysis of existing information system. There are used methods SWOT and HOS 8. Based on the results of these methods are designed the suggestions to improve. The suggestions include a description of optimization and economic evaluation.

National Repository of Grey Literature : 26 records found   previous11 - 20next  jump to record:
See also: similar author names
3 Hájek, Marcel
8 Hájek, Martin
2 Hájek, Matouš
3 Hájek, Matyáš
5 Hájek, Matěj
1 Hájek, Michael
10 Hájek, Michal
19 Hájek, Milan
2 Hájek, Miloš
3 Hájek, Mojmír
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