National Repository of Grey Literature 22 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Vliv monotónní činnosti na vybrané fyziologické funkce operátorů lesnických harvestorů
Hájek, Miroslav
The characteristic feature of today's human is the ability to produce complex tools and then use them to influence their surroundings for their own benefit. Thus man constantly influences his surroundings by the activity of the world, and the energy that he makes from himself, he returns sooner or later in a different form. They are very often negative influences affecting his or her mental and health condition, which derives from the correct or gradually worsening human physiology. In this bachelor thesis, we will not only deal with selected physiological functions without which we would not survive for a long period of time, but also with the impact on these functions of monotony, which is a frequent problem of many of today's professions. In this case, we will deal with the harvester operator post.
Antenna for smart watch
Hájek, Miroslav ; Láčík, Jaroslav (referee) ; Cupal, Miroslav (advisor)
The objective of this work is a create a smart watch antenna, that will operate in two frequency bands. These are GSM (1.8 GHz) and ISM (2.4 GHz) bands. This antenna must be able to work when be placed on an elastic material that is used as a smart watch belt. Antennas options are analyzed and their suitability for given use. There is also an antenna model in CST microwave studio, where all the simulations were made. The antenna is also simulated on human hand models that have different dimensions and tissue ratios.
Modulation of human telomerase activity by nucleoside and nucleotide analogues
Hájek, Miroslav ; Votruba, Ivan (advisor) ; Fajkus, Jiří (referee) ; Hejnar, Jiří (referee)
CONCLUSIONS Considering human telomerase as a promising target of anti-cancer therapy, the thesis deals with the study of inhibitory potency of selected ANP diphosphates towards telomerase, and the capability of nucleoside-type DNA methylation inhibitors to inhibit hTERT expression, knowing that hTERT expression closely correlates with telomerase activity in vitro and in vivo. The results can be summarized as follows: All the purine ANP diphosphates except for (S)-PMPApp and 6-Me2PMEDAPpp show dose- dependent inhibition of human telomerase in cell-free assay, the adenine derivatives are less effective inhibitors than the guanine derivatives. The only two pyrimidine ANP diphosphates tested (PMECpp and PMETpp) do not show any significant inhibitory potency towards telomerase. Activity of tested ANPs on telomerase is limited to their diphosphates (ANPpp) only. (R)-enantiomers are more inhibitory compared to (S)-enantiomers. This indicates that absolute configuration plays an important role in the telomerase inhibition and that the enzyme distinguishes between the (R)- and (S)-enantiomers. PMEGpp is the most potent human telomerase inhibitor among all ANPs studied with the IC50 value of 12.7 ± 0.5 mol.l-1 at 125 M dNTPs. Its inhibitory potency towards telomerase is comparable to that of ddGTP (IC50...
Antiproliferative, antioxidant and anti-inflammatory activity of quinones, terpenoids and their derivatives
Přibylová, Marie ; Vaněk, Tomáš (advisor) ; Smrček, Stanislav (referee) ; Hájek, Miroslav (referee)
Plant compounds play an important role in human medicine. They are a source of new drugs or serve as an inspiration for drugs' development. This thesis presents a study about syntheses of derivatives and biological activities of two groups of natural products, quinones and terpenoids. Terpenoids are plant secondary metabolites which are known for their antimicrobial, anti-inflammatory and anti-tumoral activities. We have focused on two representatives, paclitaxel and carvacrol. GnRH-paclitaxel anti-tumor conjugates potentially suitable for targeted delivery to cancer cells were prepared. Their antiproliferative activities in vitro were evaluated on MCF-7 cancer cell line and cytotoxicity in rat hepatocytes. Carvacrol and its derivative were tested for its possible anti- inflammatory effect, which was assessed in vitro as their potential to inhibit prostaglandin E2 biosynthesis via cyclooxygenase pathway. Quinones, other targets of the thesis, are well-known for biological activities similar to terpenoids. Thymoquinone, juglone and their derivatives were tested in vitro as inhibitors of cyclooxygenases and 5-lipoxygenase. Derivatives of juglone were prepared to help us to suggest structure-activity relationship of this compound. Thymoquinone and its derivatives were evaluated for their antioxidant capacity...
The role of microRNAs in chronic lymphocytic leukemia
Moravec, Martin ; Macůrková, Marie (referee) ; Hájek, Miroslav (advisor)
2 Abstract MicroRNAs (miRs, miRNAs) are recently discovered molecules (19-25 nucleotides long) that regulate gene expression at post-transcriptional level by either blocking protein synthesis or mRNA degradation. As a part of gene silencing mechanism, miRNAs are involved in cellular processes, such as apoptosis, cell proliferation, development and viral defence. miRNAs have been intensely studied in connection to disease pathogenesis. Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries affecting mostly elderly people. In my work I focus on explanation of miRNA functions and their contributions to chronic lymphocytic leukemia (CLL). I describe previously published data about miRNA-15, miRNA-16, miRNA-143, miRNA-145 and miRNA-155 in connection to this disease. Based on recent reports, I also discuss the potential role of miRNA-326 in CLL pathogenesis.
Management of textile waste from housholds in Czech Republic
Nencková, Lucie ; Hadrabová, Alena (advisor) ; Lisa, Aleš (referee) ; Hájek, Miroslav (referee)
Proper consumer attitude towards textile products and optimal post-consumer waste management of textile waste is connected with many benefits. Despite this fact, little research has been conducted on these topics. Textile waste represented mainly by donated textile from households and its material flow in waste streams mirrors the behaviour of our consumer society as well as new technologies in textile and fashion industry. More information about consumer attitude and behaviour toward textile and textile waste is needed to provide suitable waste management processes according to the hierarchy of waste management, such as re-use and energy recovery, and to ensure sustainable development and minimal impact on the worlds wellbeing. This study takes into account not only waste management of textile waste, but also tries to understand all textile issues in a wider perspective. Particularly fashion industry is connected with many negative ethical aspects (e.g. sweatshops), and many environmental issues are connected with overproduction of lower-quality textile products. Proper handling of post-consumer textile products is only one of the product life cycle stages to be solved. The main goal of this study is to discuss the results of a consumer attitude and behaviour questionnaire toward textile and textile waste from households in the Czech Republic. The study also includes partial hypotheses and an analysis of interest groups as other possible sources of information to form proper textile waste management policy tools and strategies.
Assessment of Policy Changes of the Impacts of Urbanization, Economic Growth and Decentralization of Water Services with Regard to Water Quality in Mexico
Lara Cervantes, René Fernando ; Šauer, Petr (advisor) ; Dvořák, Antonín (referee) ; Hájek, Miroslav (referee)
The thesis studies the case of water quality in Mexico as a crucial factor to prevent water scarcity. This is an important issue for Mexico since more than half of its territory is arid or semi-arid; moreover, the most productive regions are located in areas with significant water resources stress. In this regard, the current situation of water scarcity is studied from the changes in water management derived from the evolution of institutions in the country. The institutional changes were analyzed mostly in the transition from a centralized water supply and sanitation services with strong state intervention to the decentralization of such services that were transferred to municipalities. Decentralization was addressed by analyzing the performance of water supply and sanitation services in urban areas that are expected to continue growing in the near future. The literature shows that the decentralization process has been partial and has not improved as expected the performance of water supply and sanitation services, moreover, due to political reasons, limited human and financial resources it introduced more challenges to the accomplishment of sustainable water management. More importantly, the federal government is still the main agent for the development of the water sector in Mexico. The next part of the analysis consist of a quantitative and qualitative evaluation regarding water quality for the three most productive Hydrological-Administrative Regions (HARs) of Mexico in the period of 2003-2013. The HARs chosen are the HAR VI Río Bravo, HAR VIII Lerma Santiago Pacific and HAR XIII Waters of the Valley of Mexico which are very similar in terms GDP share and water stress degree. Through OLS regression models for each HAR the impacts of demographic, economic, water supply and sanitation services aspects were tested to known their effects on water quality. In order to improve the discussion of the results, additional to the comparison with the results of the literature review, three experts were asked to answer a questionnaire about the regressions outcome. The discussion showed different impacts of the independent variables in the dependent variable of each HAR, sometimes leading to unexpected results. The main conclusions of the thesis relate to the improvement of decentralization of water and sanitation services, to the need to improve data for future analyses and pay more attention to water quality issues. In this regard, decentralization requires to consider contextual differences in order to seize its advantages to improve the performances of water supply and sanitation services, moreover, at the operative level water management decisions must be taken without political interests involved. The statistical analyses stressed the need to develop more reliable data about water management issues to improve the understanding of factors that could potentially affect water quality. In this regard, the creation of useful statistical indicators to assess the evolution towards sustainability in water management. The considerations for future research must consider more seriously water quality issues. This topic has been often ignored, however, it is crucial for water scarcity abatement.
Analysis of Organizational Arrangement of Environmental Protection
Lípa, Jan ; Hájek, Miroslav (advisor) ; Hrib, Michal (referee)
The paper deals with the current form of organizational arrangement of environmental protection in the City of Prague at the level of districts, administrative wards and municipality. It assesses the effectiveness of organizational arrangement and shows disunity of organizational structure. Describes the process of decision making. The paper finds unsatisfactory state, which, however, no one has addressed so far. It analyzes possible solutions and presents options of optimal solution and approach consisting in a reduction of municipalities themselves within the reform of public administration, or in a transfer of execution of public administration to a higher level -- i.e. the administrative ward. It also deals with a number of other related issues, such as administrative workload of staff members and proposes, among other things, to desist from not necessary activities. The text does not assess directly the actual economic effectiveness of the work, for which much more data would be required.

National Repository of Grey Literature : 22 records found   1 - 10nextend  jump to record:
See also: similar author names
2 Hájek, Marcel
6 Hájek, Martin
2 Hájek, Matouš
2 Hájek, Matyáš
4 Hájek, Matěj
1 Hájek, Michael
10 Hájek, Michal
18 Hájek, Milan
2 Hájek, Miloš
3 Hájek, Mojmír
Interested in being notified about new results for this query?
Subscribe to the RSS feed.