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Effective Dynamic Programming in Bioinformatics
Franěk, Jaromír ; Hynek, Jiří (referee) ; Burgetová, Ivana (advisor)
Purpose of this thesis is to study principle of effective algorithms, that are using dynamic programming. Using this knowledge to create application demonstrating principle of effective algorithm of dynamic programming in bioinformatics and write a report summarizing results. Algorithms used in this thesis are solving DNA sequence alignment or RNA secondary structure prediction. These algorithms are compared between themselves based on different input values. For DNA sequence alignment are used algorithms such as Needleman-Wunch and X-drop. For prediction of secondary RNA structure is used Zuker algorithm, that should remove some of Nussin algorithm weaknesses and Nussin algorithm itself. Recursion is showed by recursion trees. Dynamic programming is showed by score matrix. User also have ability to compare speed of both approaches for given sequences. It is programmed as web application, that run on client's side. This ensure easy availability.
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The Utilization of Process Management in Chemistry Laboratory
Franek, Jiří ; Šunka,, Josef (referee) ; Jurová, Marie (advisor)
This diploma thesis deals with application of business process management principles to the order processing in chemical laboratory. In the first section of the work is accounted history and evolution of business process management and launching methodology as well. In further section was analyzed wider neighborhood of the company. It was necessary to find appropriate processes suitable for the optimization. Primary activities were identified using newly modeled value added chain diagram. Primary activities were decomposed to the key processes. These processes were described using event-driven process chain diagrams. Strategic goals were determined by internal and external organization aspects. The influence of the strategic goals on the key processes was evaluated to find a process attributes which can be improved using business process management. The goal of this work was to propose possible solution for the controlling and communication infrastructure allowing operational control over nondeterministic flow of orders and further reporting. The result of this work is new structure of key processes concerning orders and their passing the organization.
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Customer Satisfaction
Franek, Jan ; Remsová,, Kateřina (referee) ; Schüller, David (advisor)
The subject of this thesis is to analyze customer satisfaction of the climbing center „Tendon Wallstreet Jihlava“. The thesis is divided into four main parts. The first part is the goals of the work and the chosen methodology. The second part contains a theoretical description, which is based on literature. In the next part I use selected methods and analyzes to map the current situation. The last fourth part is the actual proposal based on the findings of the questionnaire survey to improve the level of customer satisfaction.
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Design of an Information System Part
Franěk, Jiří ; Dydowicz, Petr (referee) ; Neuwirth, Bernard (advisor)
The dissertation analyzes the current state of IS together with defining the requirements of the company and customers for the solution. The outputs of the analytical part are based on the desing of the solution, which is designed to improve business processes and faciliate the processing of recurring activities. The solution is processed using modern approach to HTML code and CSS scripting language.
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Injection locked ring oscillator design for application in Direct Time of Flight LIDAR
Fránek, Jakub ; Háze, Jiří (referee) ; Kledrowetz, Vilém (advisor)
Diplomová práce přibližuje systémy LIDAR přímo měřící čas průletu a časově digitální převodníky určené k použití v těchto systémech. Představuje problematiku distribuce hodinových signálů napříč soubory časově digitálních převodníků v LIDAR systémech a věnuje se jednomu z nových řešení této problematiky, které je založené na injekcí zavěšených oscilátorech. Technika injekčního zavěšení oscilátorů je důkladně matematicky popsána. V programu Matlab byl vytvořen simulační model injekcí zavěšeného kruhového oscilátoru, který potvrzuje správnost uvedených analytických predikcí. Ve výrobní technologii ONK65 byl navržen injekcí zavěšený kruhový oscilátor stabilizovaný pomocí smyčky závěsu zpoždění, určený pro implementaci časově digitálního převodníku pro systém LIDAR. Navržený injekcí zavěšený kruhový oscilátor byl verifikován počítačovými simulacemi zohledňujícími vliv procesních, napěťových i teplotních variací. Oscilátor poskytuje specifikované časové rozlišení 50 pikosekund a dosahuje dvakrát nižší hodnoty fázového neklidu než ekvivalentní volnoběžný oscilátor v dané technologii.
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The optimization the production of selected medicinal substances
Fránek, Jan ; Ing.Oldrřich Smékal (referee) ; Omelková, Jiřina (advisor)
Mgr. Jan Fránek 2011: The optimization the production of selected medicinal substances The diploma thesis dealt with optimization of production of fingolimod by hydrogenation. During the optimization of production, there was reduction of benzylic hydroxygroup and nitrogroup of nitrofingotriol. Reduction of two different groups caused dividing process of hydrogenation into two phases. The original intention was to optimize production only in the autoclave, but the need of using acidic catalytical medium in first phase led to dividing the production into reduction in the reactor and following catalyzed hydrogenation, already in neutral conditions, in the autoclave. The way of preparation of active substance by using an autoclave had not been explored in detail before. Evaluation of optimization is a part of results. There are also production charges on pilot plant included in results. Because the results of procedure of the pilot unit were not uniform, it was necessary to continue in optimization even after finishing the production in pilot plant. Following procedure modified according to the latest experiments was passed to the operating process.
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Proposal of Online Marketing Campaign for a Company Expanding on a Foreign Market
Franěk, Jiří ; Schüller, David (referee) ; Kaňovská, Lucie (advisor)
The thesis focuses on the proposal of an online marketing campaign for a company expanding into the Polish market using growth hacking and the PAVORD marketing framework. The theoretical part is devoted to definition of basic concepts in the areas of online marketing, Facebook Ads Manager and advertising campaign reporting. The analytical part is dedicated to the introduction of the project, analysis of the current state, the marketing mix of the company and research on the correlation and causality of selected metrics on the success of advertising posts. The proposal part presents how to use the collected data for campaign proposal, setting up processes for managing and evaluating ad posts trough the growth hacker app.
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Integrated temperature sensor bipolar core
Fránek, Jakub ; Prokop, Roman (referee) ; Kledrowetz, Vilém (advisor)
Cílem této práce je popsat možné způsoby realizace teplotního senzoru na křemíkovém čipu v běžných CMOS výrobních technologiích a představit konkrétní implementaci analogového jádra teplotního senzoru využívajícího bipolární tranzistory ve výrobní technologii TSMC 110. Techniky jako chopping, dynamic element matching nebo trimování byly použity k navržení obvodů, jejichž simulovaná 3 přesnost měření je ±3.5 °C bez trimování nebo ±0.6 °C s po jedné trimovací operaci napříč vojenským teplotním rozsahem. Navržené obvody zabírají pouze 0.012 mm čtverečních plochy čipu a jejich celkové parametry jsou srovnatelné s výsledky současných publikovaných prací.
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Empty Shells. Three Tales on the Relativization of the Axiological Core of Democracy
Horák, Filip ; Franěk, Jakub (advisor) ; Salamon, Janusz (referee)
Empty Shells. Three Tales on the Relativization of the Axiological Core of Democracy - Abstract JUDr. Bc. Filip Horák The purpose of this thesis is to discuss the problem of gradual softening of the democratic political system's axiological core. Firstly, the thesis illustrates the problem via three tales narrated by Carl Schmitt, Hannah Arendt and Leo Strauss, who in a very similar manner critically analyzed the "axiological leap" leading to the disintegration of fundamental values and principles of democracy. Secondly, the thesis offers a new methodological approach combining empirical functional analysis of the individual values constituting democracy's axiological core (i.e. equality, liberty, justice and dignity) with a teleological approach focusing on the original purposes and functions of these values. Using functional analysis, the thesis examines possible interpretations and functions of the aforementioned values and shows that all of them evince a high degree of vagueness and ambiguity, which makes them so-called "empty shells" that can be filled with almost any content, meaning or function. This is also the main cause of the disintegration of the democracy's axiological core. Thirdly, the thesis theoretically reconstructs the original and stable axiological core using teleological approach....
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Political Thought of Czechoslovak Dissidents in the Years 1977 - 1993
Švehlová, Veronika ; Halamka, Tomáš (advisor) ; Franěk, Jakub (referee)
The diploma thesis entitled The Political Thought of Czechoslovak Dissidents in the Years 1977 - 1993 examines the political thought of three representatives of Czechoslovak dissent, Rudolf Battek, Václav Havel and Václav Benda. The main aim is to find out whether the Czechoslovak dissent included political thinking and came up with its own constructive theories on the ideal state system or whether it was limited to criticism of the contemporary regime. In terms of methodology, the thesis works with textual analysis of primary sources of three selected dissidents. Based on the textual analysis, it concludes by using a comparative method to compare and integrate the political thought of the selected dissidents with a focus on a better or ideal arrangement of the future state. The thesis concludes that the analyzed representatives of Czechoslovak dissent, in addition to criticizing the regime, also focused on political thinking and searched for a future state organization. Political thought and theories of a successful state were not their primary concern and do not represent a systematic positive theory. Their political thinking was based on their overall philosophical ideas and the context of their critique of the communist regime in contemporary Czechoslovakia. They do not call their ideas...
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