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The role of DNA minor groove deformation in specific recognition of DNA by proteins
Faltejsková, Kateřina ; Vondrášek, Jiří (advisor) ; Lepšík, Martin (referee)
The specific recognition of the DNA is crucial for the correct functioning of the cell. Although its mechanisms are extensively studied, the actual process is not yet fully understood, partly due to the variance observed in readout mechanisms so far. In this work, a particular type of specific recognition is examined: the shape readout in the DNA minor groove. Based on a sta- tistical analysis of three-dimensional structures of protein-DNA complexes acquired from the Protein Data Bank, I propose a previously unrecorded readout mechanism of widened minor grooves by hydrophobic amino acids. In addition, the effect of DNA sequence on the topography of the contacted locus, the preferred secondary structures and the interaction between the protein and DNA are explored, as well as the relative information amount of examined features concerning the DNA deformation. 1
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The Influence of the Jewish Lobby on U.S. Foreign Policy
Faltejsková, Kateřina ; Havlová, Radka (advisor) ; Knotková, Vladimíra (referee)
The subject of this thesis is to analyse the influence of "The Israel lobby" on the foreign policy of the United States of America. The work examines issues of lobbying, methods of its definition and delimitation. Furthermore, it analyzes the emergence and development of this lobby and introduces its main leaders and influential pro-Israel organizations. Finally, it analyses the effect of the lobby during the administration of some U.S. presidents such as John Kennedy, Richard Nixon, Jimmy Carter or Barack Obama. In conclusion, it examines the influence of this lobby in Congress, Pentagon and on campuses. The aim of this work is to prove that "The Israel lobby" has such a big impact that it is able to influence the decisions of the President of the United States, including political institutions.
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The influence of the Jewish diaspora in the U.S. on United States foreign policy towards the Israeli-Palestinian conflict
Faltejsková, Kateřina ; Havlová, Radka (advisor) ; Novotná, Yvona (referee)
This thesis examines the influence of the Jewish diaspora in the U.S. on United States foreign policy towards Israel, and especially to the Israeli-Palestinian conflict. The theoretical part is aimed at explanation of the concept of diaspora and its influence on international relations. It examines the development of the Jewish Diaspora from its beginnings to the present, focusing in particular on the United States. The second part deals with the pro-Israeli lobby and its influence on the legislative and executive power in the United States and describes the most significant pro-Israeli organizations. In the end the thesis examines the Israeli-Palestinian conflict, his key historical aspects and especially the policy of the last three U.S. presidents: W. J. Clinton, G. W. Bush and B. Obama.
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