National Repository of Grey Literature 4 records found  Search took 0.01 seconds. 
Chronotypes and Social Jet Lag Related to Obesity
Halászová, Andrea ; Fárková, Eva (advisor) ; Červená, Kateřina (referee)
In nature we can observe plenty of actions which show some kind of regularity as they repeat with a certain period. The circadian rhythm with its period of approximately one day belongs among these. The circadian rhythm is synchronized mainly by light, but there are also many other internal and especially external synchronizers such as the society we live in. In an organism many processes show circadian rhythmicity, but everyone has the rhythm adjusted individualy, thus called chronotype. It's indeed very important to note that living in harmony with the chronotype is essential. Social jet lag is the term for a long-term disbalance and circadian desynchrony as a consequence of the need to adjust this individual circadian preference to the regime set by the society we live in. Many of recent studies support the findings, that social jet lag might have an impact on health and could participate in development of some of the lifestyle diseases such as obesity. Therefore it should be found beneficial to apply those finding in a clinic practise not only in order to help with an efficient treatment of obesity and its consequences but also in preventing it.
The relationship between circadian system and cell cycle
Vrtílková, Andrea ; Bendová, Zdeňka (advisor) ; Fárková, Eva (referee)
The circadian system is able to oscillate by itself owing to the transcriptional-translation feedback loop. Components of this loop do not affect just their own run, but they also have an impact on some other functions of the cell, for example cell cycle. This interaction is made by clock proteins (PER, CRY etc.) and by clock-controlled proteins (WEE1, TIM, XPA etc.). These proteins participate in the cell cycle run and have an impact on check-points. Disruption of the circadian clock can cause faults in cell cycle check-points, storing of DNA damages and increased cell apoptosis or tumor progression. Key words: circadian systém, cell cycle, WEE1, XPA, P21, C-Myc, TIM, PER
The role of microRNAs in pathogenesis of placental insufficiency - related pregnancies
Fárková, Eva ; Hromadníková, Ilona (advisor) ; Korabečná, Marie (referee)
MicroRNAs (miRNAs) are small noncoding RNAs of length ranging from 18 to 25 nucleotides that regulate gene expression at posttranscriptional level. Expression of some miRNAs is tissue specific. This task assumed that placental insufficiency related pregnancy complications may be characterised by the dysregulation of microRNAs that are crutial for the regulation of cardiovascular system and cardiovascular diseases. The gene expresion of 32 cardiovascular miRNAs was studied in two types of biological material - placental tissue and maternal whole peripheral blood. Patient cohort of clinically manifested preeclampsia (PE), gestational hypertension (GH) and intrauterine growth restriction (IUGR) was compared with samples derived from normal pregnancies (FG). In total, 127 placental tissue samples (20 FG, GH 20, 20 IUGR , 67 PE) and 80 maternal whole peripheral blood samples (20 FG, GH 20, 20 IUGR , 20 PE) were processed. Before the research, two pilot studies focused on the selection of endogenous controls for data normalization of gene expression in both types of biological material were performed. Detection and quantification was carried out by quantitative real-time PCR. In a group of placental tissue several miRNAs showed elevated levels in GH (miR-1, miR-16, miR-17, miR-20a, miR-21, miR-23a,...
Růžena Svobodová: The woman in the Czech society at the turn of the 19th and the 20th Century. The chapters from the life and action of Růžena Svobodová.
Farková, Eva ; Kvaček, Robert (advisor) ; Pokorná, Magdaléna (referee)
The study delineates a picture of the woman writer, Růžena Svobodová, as an example of possible realization of a woman in the Czech society at the turn of 19th and 20th century. The woman writer, Růžena Svobodová, is introduced here in her many activities. Attention is paid to her works of fiction, in which she views the picture of contemporary woman and her position in society. The study reveals also the area of the woman writer's literary salon and summarizes its influence on the Prague society at the turn of 19th and 20th century. Included is also a portrait of Růžena Svobodová the woman journalist, which so far has been a neglected area. The study contains also a view of the woman writer's activities in the Czech Heart charitable organisation operating during World War I.

See also: similar author names
2 Farková, Eva
1 Fárková, Eliška
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