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	Úloha synthasy acetohydroxykyselin z Corynebacterium glutamicum v biosyntetické dráze valinu Elišáková, Veronika Detailed record
	Úloha synthasy acetohydroxykyselin z Corynebacterium glutamicum v biosyntetické dráze valinu Elišáková, Veronika Detailed record
	Genetické modifikace v drahách biosyntéz aminokyselin s rozvětveným řetězcem u Corynebacterium glutamicum Pátek, Miroslav ; Holátko, Jiří ; Elišáková, Veronika Biosynthesis pathways of branched-chain amino acids (valine, leucine, isoleucine) are controlled by a complex regulatory system. To improve valine production by C. glutamicum, modifications (mutations) of promotersof genes ilvA, ilvB, ilvD, ilvE and leuA were constructed within the chromosome. The modulations of promoter strength (up or down mutations) resulted in an efficient valine producer Detailed record
	Vliv stringentní odpovědi na produkci valinu u Corynebacterium glutamicum Prouza, Marek ; Holátko, Jiří ; Elišáková, Veronika ; Nešvera, Jan ; Pátek, Miroslav The aim of this study was to compare the production of valine in C. glutamicum producers with the level of valine produced by the strain with deletion of the rel gene coding for enzyme guanosine tetraphosphate synthetase Detailed record
	Modulace genové exprese mutagenezí v promotorech Corynebacterium glutamicum Holátko, Jiří ; Elišáková, Veronika ; Prouza, Marek ; Phensaijai, M. ; Nešvera, Jan ; Pátek, Miroslav Studies of structure and function of promoters in C. glutamicum were used in graded expression of genes involved in biosynthetic pathway of valine (ilvBNC, ilvD, ilvE) and in competing or branching-off pathways (ilvA, leuA). Combination of particular promoter mutants resulted in tuning the whole pathway to overall higher flux of the intermediates through the pathway and in high production of valine Detailed record
	Modulace metabolických toků biosyntetickými drahami aminokyselin s větveným řetězcem u Corynebacterium glutamicum Pátek, Miroslav ; Elišáková, Veronika ; Holátko, Jiří Metabolic fluxes in pathways of biosynthesis of branched-chain amino acids can be modulated by different changes in expression of genes of the desired pathway as well as those of competing pathways. Site-directed mutagenesis of promoters of the respective genes is a suitable tool to obtain desired changes in gene expression. Detailed record
	Konstrukce kmenů Corynebacterium glutamicum s nadprodukcí valinu Elišáková, Veronika ; Holátko, Jiří ; Pátek, Miroslav Promoters of genes involved in biosynthesis of branched-chain amino acids in Corynebacterium glutamicum were mutagenized. The promoters with increased or decreased activities were used for construction of novel valine-overproducing strains Detailed record

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