|
|
Neurological deficit after focal cerebral ischemia in rat - pharmacological intervention
Eliášová, Karolína ; Otáhal, Jakub (advisor) ; Svoboda, Jan (referee)
Title: Neurological deficit after focal cerebral ischemia in rats - pharmacological intervention Objectives: The goal of the thesis was to determine the effect of 7-nitroindazole, a selective inhibitor of neuronal nitric oxide synthase, after focal ischemic stroke in rats. Methods: Twenty adult male Wistar rats were used in this experiment. The rats were randomly divided into four groups: ischemic stroke was given to half of them, the rest were sham operated. 10 animals were given 7-nitroindazole (25mg/kg) to protect neuronal ischemic brain damage. After a few weeks the rats were tested with a set of behavioral tests: Ladder rung walking test, Bar holding test, Rotarod test and Open field test. To evaluate the volume of brain damage the stereotactic method was used. The brain sections were cut and compared with atlas. This study was supported by Institute of Physiology, Academy of Sciences ČR in Prague. Results: The present results show that the 7-nitroindazole has no side effects on healthy rats. The long-term effect on rats after ischemic stroke was not proved. There were a few positive trends observed such as an increase of locomotor speed, increased explorative behaviour and better coordination outcome on RotaRod. On the other hand the brain tissue damage was bigger and the time of hanging in...
|
|
|
A case of physiotherapeuticcare of a patient with rheumatoid arthritis
Eliášová, Karolína ; Kučerová, Ilona (advisor) ; Taušová, Eva (referee)
Title: A case of physiotherapeutic care of a patient with rheumatoid arthritis Objectives: The major aim of this thesis is to highlight the role of a physiotherapist as a part of the interdisciplinary team in the complex treatment of rheumatoid arthritis and to demonstrate the effect of special physiotherapeutical methods in practice. The thesis includes a detailed case report of a patient with rheumatoid arthritis. Methods: This thesis was made within the four weeks of practical training at the Institute of Rheumatology in Prague in the period from 2. 1. 2017 to 27. 1. 2017 under the guidance of Mgr. Iva Zinková. The thesis is divided into two parts: general and special. The general part is focused on processing the issues of the disease rheumatoid arthritis, deals with the characteristics, origin, symptoms, course of disease, diagnosis, examination and treatment. Included in the special part is a case report of physiotherapy care of the patient, including case history, entry kinesiological analysis, target, design and course of treatment, control kinesiology analysis and evaluation of the effect of therapy. Results: A control kinesiology analysis was performed after six treatments. It demonstrates the improved clinical status of the patient with rheumatoid arthritis. Keywords: rheumatoid...
|
guest ::
RSS feed.