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The Students themselves - Student Center Poříčí
Dvořáková, Eva ; Bambuchová, Jarmila (referee) ; Sochor, Jan (advisor)
The proposed building responds to a chamfered corner of the solved plot by turning the mass of the dining hall on the ground floor and the mass of the student dormitory above it. Under the protruding upper mass arises covered main entrance to the building. The ground floor of the building is directly connected to the adjacent hotel Austerlitz. The higher levels are stepping back from the street front. The mass of the student dormitory respects here the current glass corner on the top floor of the building Austerlitz. The facades to the streets Táborského nábřeží and Vídeňská are covered with a wire mesh to enable the creepers grow on it. There will be gaps in the wire mesh in front of the windows to the student rooms. The student housing is designed as maisonettes. These two storey maisonettes are divided into several groups including 5 to 8 rooms. Each group has its own “living room” and kitchenette.
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Use of plasma jet for wound healing
Dvořáková, Eva ; Márová, Ivana (referee) ; Skoumalová, Petra (advisor)
This diploma thesis was focused on the possibility of using a plasma nozzle to accelerate the wound healing process. The benefits of using low-temperature plasma in medicine or biomedical applications are known from many studies, and low-temperature plasma is already used to sterilize medical devices, materials or surgical instruments. Some studies also report a high potential of usinh plasma nozzle in the treatment of skin wounds. In the experimental part of this work, an in vitro wound healing test was performed using two different low-temperature plasma sources. Source No. 1 was a surface wave microwave discharge and source No. 2 was a torch microwave discharge. An in vitro scratch healing test was performed on a monolayer of HaCaT keratinocytes and testing was performed using various parameters. The influence of the plasma treatment time was monitored, as well as the influence of the plasma discharge power and also the influence of the argon working gas flow. Especially when using a torch microwave discharge, faster wound healing was recorded at most of the parameters used compared to the control. Thus, it can be said that this source appears to be potentially suitable for faster wound healing. Furthermore, in the work using the MTT cytotoxicity test, the viability of skin cells after their plasmination was also monitored using the same conditions as in the in vitro wound healing test. When performed in the standard MTT assay, none of the settings or sources used showed any cytotoxic effects on keratinocytes. LDH cytotoxicity tests were also performed concurrently to verify the accuracy of the MTT assays. The results of both tests agreed and the use of low-temperature plasma in skin treatment can be considered as safe. Overall, the results show that the plasma nozzle can find use in medicine in the healing of skin wounds and chronic defects as a potentially fast, inexpensive and effective method.
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Isolation and characterization of natural antimycotics and their potential applications
Dvořáková, Eva ; Hoová, Julie (referee) ; Skoumalová, Petra (advisor)
This bachelor thesis was focused on preparation and characterization of products containing natural antimycotic ingredients. The theoretical part summarizes the current issue of increased presence of mycoses and yeast diseases in connection with the extension of the problem of reduced immunity. Furthermore, the problem of synthetic drugs and antimycotics compared to alternatives of natural origin was described. In the experimental part, selected extracts (aqueous, ethanolic and lipidic) were prepared, characterized and subsequently encapsulated into liposomes. The content of polyphenols, flavonoids and the total antioxidant activity of extracts was measured. In liposomes, the encapsulation efficiency, size, stability and long-term stability were measured. In addition, the antimycotic activity of individual extracts and liposomes against Candida glabrata was studied. For comparison, the antifungal activity of the commercial drug clotrimazole was also tested. Lipidic extracts showed highest antimycotic activity from all of the prepared extracts, which is why these extracts were used to prepare antifungal gels and suppositories. More specifically, lipidic extracts of nasturcium, cinnamon, ginger and liposomes containing them were used. Their antimycotic activity was also tested and confirmed for these preparations. Finally, the cytotoxicity test on the HaCaT human cell line showed that used extracts and liposome particles are safe and that the prepared products could thus serve as an alternative to synthetically prepared antimycotics in the future.
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HOUSE ON THE FOOTHILL - TOWN HOUSE IN THE HISTORICAL CENTRE
Dvořáková, Eva ; Rudiš, Viktor (referee) ; Oplatek, Jiří (advisor)
The main objective of the master´s thesis was a design of the town house in the complicated topografical situation of the foothill of Pekařská street. The topography of the building site is influenced by its surroundings. The street Pekařská is lowering from east to west, but the road Anenská is rising from east to west. The biggest difference between the the lowest and the highest point of the site is 7,5 m. This situation enables to design three entrances to three different floors of the building. An outstanding point of the design of the house is a composition axis which is running up Pekařská street. The town house is facing this axis thus the main entrance of the house is accented. There was a compact house designed, which takes advantage of its very good position – there is a two-floor solution with a shopping mall. The hall in its middle is opening over two floors and it is lightened through a roof lightwell. On this platform is situated an „L“ shaped part of the building, which creates a protection against very noisy Pekařská street. The house is opening its form to the south, to a sunny roof garden. This garden is opened only for inhabitants of the house. The garden improves the quality of the living in the house and substitutes a green area, which used to be in this place. The shape of the building is lowering down from Pekařská street to Anenská road. There are some terraces designed this way to improve the living in the roof apartments and provide a beatiful view to the west.
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Kvalita života ve městě Třebíč
Dvořáková, Eva
This bachelor thesis is focused on the quality of life in the city of Třebíč. The aim of the thesis is to find out the current situation concerning the quality of life by means of analysis. The content of the theoretical part summarizes the existing knowledge of the literature on the subject. Subsequently, the practical part is devoted to the evaluation of the research itself. In the conclusion of the thesis, recommendations will be proposed that would lead to an improvement in the quality of life.
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Effect of zearalenone on reproductive parameters and the expression of selected genes in mice.
Dvořáková, Eva ; Pěknicová, Jana (advisor) ; Nedvídek, Josef (referee)
A number of chemicals may have a negative impact on the environment and wildlife. Endocrine disruptors (EDs), which can mimic estrogen, interfere with natural hormones in organism and can have a negative effect on the reproductive system. Such substances include zearalenone (ZEA) - mycotoxin, produced by the fungi Fusarium. Despite the non-steriodal structure of its molecule, ZEA and its derivates possess potent estrogenic activity. The influence of ZEA on reproductive parameters and changes in expression of selected genes were tested in the outbred line of mice. This study showed significant effects of ZEA on number of reproductive performances. This effect was observed at lower examined dose, to which are humans normally exposed, and at higher doses, both showed changes in the tested parameters.
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