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Comparison of metabolic parameters, hormonal level changes and cardiovascular risk in patients with gestational diabetes with healthy pregnant controls using ECG mapping method and other noninvasive cardiologic methodics
Žákovičová, Eva ; Charvát, František (advisor) ; Ošťádal, Petr (referee) ; Rušavý, Zdeněk (referee)
History of GDM not only increases the risk of developing type 2 diabetes mellitus, but also the risk of cardiovascular disease that is independent of type 2 DM. Hyperglycemia leads to significant electrophysiological, functional and structural changes in the cardiovascular system and they are interrelated. One of our main goals was to evaluate metabolic and hormonal changes and detect changes in the cardiovascular system and assess their mutual relations in condition of optimal metabolic control using a predetermined treatment algorithm. Echocardiography findings in our group of patients with GDM confirm the presence of incipient structural changes in left ventricular (significantly thicker IVS, PWD and RWT) compared to the control group. The original finding is that, under optimal compensation of diabetes any of monitored parameters of left ventricular diastolic function have not been changed. Furthermore, we found that complex metabolic care with optimal values of blood sugar together with weight gain monitoring in women with GDM leads to improvement of the 24-hour blood pressure profile without increased prevalence of non-dipper women and that nocturnal decline in BP depends on fasting plasma glucose. ECG body surface mapping did not show statistically significant changes in depolarization and...
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Cone Be am CT in dentistry: Motion artifacts and their reduction
Hanzelka, Tomáš ; Beneš, Jiří (advisor) ; Charvát, František (referee) ; Mazánek, Jiří (referee)
Cone Beam Computed Tomography (CBCT) allows effective 3D imaging in dentistry. CBCT consists of a planar detector and a x-ray source that rotate once around patient`s head. The x-ray beam is cone-shaped and is directed through the whole volume of interest. All the data needed are obtained during a single rotation of the source and detector. This rotation takes from several to several tens of seconds, and during this time the CBCT captures several hundred of 2D images. They represent different points of view on the region of interest and are later reconstructed to form a 3D data set. The biggest advantage of CBCT is that it can produce 3D image using at radiation doses similar to those of conventional diagnostic methods used in dentistry (Pauwels et al., 2010). In the experimental part of our experiment, we address one of the biggest weaknesses of CBCT - patient movement during scanning which has a major impact on the image quality and is currently the main limiting factor in the further development of this technology. In the first part of our experiment, we recorded movements of patients and CBCT scanner using a high speed camera and subsequently analyzed the data in MatLab program. Significant level of patient motion as well as motion of CBCT scanner was demonstrated. Motion was highest at the...
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