National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Studying the distribution of substituents in derivatives based on hyaluronane
Sedláček, Jakub ; Šatínský, Dalibor (advisor) ; Zimčík, Petr (referee) ; Chmelař, Josef (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate Ing. Jakub Sedláček Supervisor doc. RNDr. Dalibor Šatínský, Ph.D. Title of Doctoral Thesis Studying the distribution of substituents in derivatives based on hyaluronan Derivatives based on hyaluronan have found applications in various areas of medicine. Prepared derivatives are commonly characterized by their molar mass and their degree of substitution, however, such parameters are unable to distinguish among derivatives with different distributions of substituents along the chain, which may exhibit different macroscopic properties. For this reason, methods to determine the distribution of substituents along the chain are needed. The presented thesis deals with the determination of distribution of amino groups in deacetylated hyaluronan. The theoretical part starts with a description of hyaluronan structure and of its derivatives. Next, the application, the preparation, and the characterization of deacetylated hyaluronan are discussed, focusing particularly on its depolymerisation into oligosaccharides using deaminative cleavage or enzymes that degrade hyaluronan. Finally, examples of liquid chromatographic methods used to analyse hyaluronan oligosaccharide are presented. The experimental part...
Studying the distribution of substituents in derivatives based on hyaluronane
Sedláček, Jakub ; Šatínský, Dalibor (advisor) ; Zimčík, Petr (referee) ; Chmelař, Josef (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate Ing. Jakub Sedláček Supervisor doc. RNDr. Dalibor Šatínský, Ph.D. Title of Doctoral Thesis Studying the distribution of substituents in derivatives based on hyaluronan Derivatives based on hyaluronan have found applications in various areas of medicine. Prepared derivatives are commonly characterized by their molar mass and their degree of substitution, however, such parameters are unable to distinguish among derivatives with different distributions of substituents along the chain, which may exhibit different macroscopic properties. For this reason, methods to determine the distribution of substituents along the chain are needed. The presented thesis deals with the determination of distribution of amino groups in deacetylated hyaluronan. The theoretical part starts with a description of hyaluronan structure and of its derivatives. Next, the application, the preparation, and the characterization of deacetylated hyaluronan are discussed, focusing particularly on its depolymerisation into oligosaccharides using deaminative cleavage or enzymes that degrade hyaluronan. Finally, examples of liquid chromatographic methods used to analyse hyaluronan oligosaccharide are presented. The experimental part...
Police aktivity in the searching for persons in the territory of Strakonice distric
CHMELAŘ, Josef
The topic of this bachelor thesis is "Activities of the Police of the Czech Republic in the search for persons on the territory of the District of Strakonice". How the results contained in the research section of this work, so from the general subconscious mind, I can conclude that the missing people are constantly on the increase. Therefore, it is necessary to pay close attention to the ongoing development of this issue. In the theoretical part of the bachelor thesis I deal with the integrated rescue system, its structure, basic and other components of the IRS. Furthermore, in the theoretical part I deal the Police of the Czech Republic, where I'm describing police s present, basic legislation, structure, tasks and activities of the individual services of the Police. In the theoretical part I also describe the basic characteristics of the District of Strakonice, where I present the basic history of the town Strakonice, the geographical description, the social services and education of the population on the territory of Strakonice region. At the end of the theoretical part I deal with exploring the issue of the search for missing persons, where I describe how the Police of the Czech Republic upon receiving notification of a missing person, the methods of search events and the search resources of the Police. The practical part of the bachelor thesis consists of qualitative research. The main objective of the bachelor thesis is to assess the current state of the issue of the search for persons on the territory of the District of Strakonice. The research part is made up of the results themselves, which are handled by simple graphs. Based on the research of the investigation I've found that in the period under review can be on the territory of the District of Strakonice observed a growing trend of missing minors and adult people and, further, that the reasons for missing minors and adult people differ in the analysis period. Taking into account the results of the research it is possible to conclude that the overall view in the analysis period on the territory of the District of Strakonice observed a growing trend the missing people. In conclusion, I summarize the whole of their work, evaluating the results obtained, I suggest some measures and I use cases work in practice.

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4 CHMELAŘ, Jindřich
4 Chmelař, Jakub
7 Chmelař, Jan
2 Chmelař, Jaroslav
4 Chmelař, Jindřich
10 Chmelař, Jiří
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