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DSC study of lipid systems II
Bucharová, Veronika ; Musilová, Marie (advisor) ; Doležal, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Author: Veronika Bucharová Supervisor: RNDr. Marie Musilová, CSc. Title of diploma thesis: DSC study of lipid systems II This work deals with the interaction of skin lipids and water. The epidermal lipids (especially ceramides and cholesterol) and water create together lamellar structure which is the essence of the skin barrier. To create a lipid layer we used a cholesterol and a synthetic pseudoceramide 14S24 (synthesized at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové). The ratio of these two components is chosen so that the cholesterol in the molten pseudoceramide dissolves and during cooling down doesn't separately crystallize. Samples of this mixture with water and without water were evaluated by using differential scanning calorimetry (DSC). The samples were in high-pressure sample crucibles repeatedly heated up above and below the melting point and congealing of the mixture. We watched the changes of calorimetric characteristic that may be indicative of interaction lipid mixtures with water. We find out that value of heat of melting for inserted water decreases after adding water to mixture of cholesterol and pseudoceramide. It shows on...
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The effect of the drugs incorporation on the glass transition temperature of branched polyesters
Bucharová, Veronika ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Name of student: Mgr. Veronika Bucharová Title of rigorous thesis: The effect of the incorporation of drugs on the glass transition temperature of branched polyesters Consultant: PharmDr. Eva Šnejdrová, Ph.D. This rigorous thesis is focused on a study of the effect of the incorporation of drugs on the glass transition temperature of branched polyesters. For this experiment were used star-shaped copolymers of D,L-lactic and glycolic acid branched with 1 %, 3 % and 5 % tripentaerythritol in the reaction mixture. The way used for the incorporation of the drugs (aciclovir, fluconazole, miconazole, terbinafine basis and terbinafine hydrochloride) was based on dissolving the polyester in a suitable solvent. Methyl formate was used for dissolution. The theoretical part is devoted to linear and branched polyesters, incorporation of the drug into the polymer and the interactions between polyester and drug. Properties and application of the drugs used in the experiment were also mentioned. In the experimental part the glass transition temperature of polyesters containing 50 % of incorporated drug was measured by DSC. The decrease of the glass transition temperature of matrices was proved by...
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DSC study of lipid systems II
Bucharová, Veronika ; Musilová, Marie (advisor) ; Doležal, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Author: Veronika Bucharová Supervisor: RNDr. Marie Musilová, CSc. Title of diploma thesis: DSC study of lipid systems II This work deals with the interaction of skin lipids and water. The epidermal lipids (especially ceramides and cholesterol) and water create together lamellar structure which is the essence of the skin barrier. To create a lipid layer we used a cholesterol and a synthetic pseudoceramide 14S24 (synthesized at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové). The ratio of these two components is chosen so that the cholesterol in the molten pseudoceramide dissolves and during cooling down doesn't separately crystallize. Samples of this mixture with water and without water were evaluated by using differential scanning calorimetry (DSC). The samples were in high-pressure sample crucibles repeatedly heated up above and below the melting point and congealing of the mixture. We watched the changes of calorimetric characteristic that may be indicative of interaction lipid mixtures with water. We find out that value of heat of melting for inserted water decreases after adding water to mixture of cholesterol and pseudoceramide. It shows on...
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