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Cytotoxicity of etxract from Vaccinium bracteatum
Landa, Přemysl ; Havlík, J. ; Bradshaw, T.D. ; Chu, J. ; Maršík, Petr ; Vaněk, Tomáš ; Lou, J.D.
Vaccinium bracteatum is a shrub originating from East Asia and is traditionally used for cancer treatment, according to some ethnobotanical indications. After successive extraction of dry berries with n-hexane, dichloromethane, methanol and water, the cytotoxic activity of extracts was assessed using the 3-( 4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) colourimetric assay. Methanolic extract showed mild cytotoxic properties against MCF-7, BCT-116 and MRC-5 cell lines with lCso ranging from 186 to 285 /lg/mL, while other extracts were not active (lC50>500 /lg/mL). The potency of methanolic extract only suggests a possible role of flavonoids.
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