|
|
The influence of the tableting speed on the parameters of the stress relaxation test
Borkovcová, Renáta ; Svačinová, Petra (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Renáta Borkovcová Title of Thesis: The influence of the tableting speed on the parameters of the stress relaxation test This diploma thesis evaluates the influence of tableting speed on the viscoelasticity parameters of stress relaxation test and tensile strength of tablets. Microcrystalline cellulose Avicel® PH-200, lactose monohydrate SpheroLac® 100, calcium hydrogen phosphate dihydrate Di-Cafos® D 160 and potato starch were used as model excipients and magnesium stearate was used as lubricant. The theoretical part is devoted to informations about tablets as a dosage form and description of excipients, which where used in experimental part. Subsequently, plasticity and elasticity of material were characterized and methods of their evaluation were described. The stress relaxation test and its evaluation using the three exponential equation were characterized in more detail. The following chapters describe the influence of tableting speed and lubricants on tensile strength of tablets. The experimental part deals with viscoelastic properties of individual materials and their mixtures with lubricant at concentration of 1 %. This properties were...
|
|
|
The influence of the tableting speed on the parameters of the stress relaxation test
Borkovcová, Renáta ; Svačinová, Petra (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Renáta Borkovcová Title of Thesis: The influence of the tableting speed on the parameters of the stress relaxation test This diploma thesis evaluates the influence of tableting speed on the viscoelasticity parameters of stress relaxation test and tensile strength of tablets. Microcrystalline cellulose Avicel® PH-200, lactose monohydrate SpheroLac® 100, calcium hydrogen phosphate dihydrate Di-Cafos® D 160 and potato starch were used as model excipients and magnesium stearate was used as lubricant. The theoretical part is devoted to informations about tablets as a dosage form and description of excipients, which where used in experimental part. Subsequently, plasticity and elasticity of material were characterized and methods of their evaluation were described. The stress relaxation test and its evaluation using the three exponential equation were characterized in more detail. The following chapters describe the influence of tableting speed and lubricants on tensile strength of tablets. The experimental part deals with viscoelastic properties of individual materials and their mixtures with lubricant at concentration of 1 %. This properties were...
|
|
|
The influence of the tableting speed on the parameters of the stress relaxation test
Borkovcová, Renáta ; Svačinová, Petra (advisor) ; Ondrejček, Pavel (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Renáta Borkovcová Title of Thesis: The influence of the tableting speed on the parameters of the stress relaxation test This diploma thesis evaluates the influence of tableting speed on the viscoelasticity parameters of stress relaxation test and tensile strength of tablets. Microcrystalline cellulose Avicel® PH-200, lactose monohydrate SpheroLac® 100, calcium hydrogen phosphate dihydrate Di-Cafos® D 160 and potato starch were used as model excipients and magnesium stearate was used as lubricant. The theoretical part is devoted to informations about tablets as a dosage form and description of excipients, which where used in experimental part. Subsequently, plasticity and elasticity of material were characterized and methods of their evaluation were described. The stress relaxation test and its evaluation using the three exponential equation were characterized in more detail. The following chapters describe the influence of tableting speed and lubricants on tensile strength of tablets. The experimental part deals with viscoelastic properties of individual materials and their mixtures with lubricant at concentration of 1 %. This properties were...
|
guest ::
