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Mitochondrial function in skeletal muscle of critically ill
Urban, Tomáš ; Duška, František (advisor) ; Bořilová Linhartová, Petra (referee) ; Lipový, Břetislav (referee)
Aerobic phosphorylation in the mitochondria is an essential source of ATP for the functioning of higher organisms. It can be assumed that in critically ill patients, alterations in mitochondrial function are not only a para-phenomenon but also a cause of metabolic dysfunction and skeletal muscle function. In addition, critically ill patients are given drugs that facilitate care but may have unwanted side effects. Among these is the widely used diisopropylphenol, i.e. propofol. However, there is increasing evidence that propofol can induce propofol infusion syndrome, leading to mitochondrial dysfunction and failure, which can lead to the death of the patient. The research question in our project was whether there are differences in mitochondrial function compared to a control group in critically ill patients at different stages of the disease, and whether there is a difference between the group rehabilitating with the FES-CE device, i.e. functional electrical stimulation assisted ergometry, and the group with standard rehabilitation. Furthermore, we aimed to determine whether and how different parts of the respiratory chain are inhibited during propofol administration. In a subgroup of patients enrolled in a prospective randomized controlled trial, The Effect of Functional Electrical...
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Role of genetic factors in the etiopathogenesis of selected diseases of the oral cavity
Bořilová Linhartová, Petra
Dissertation thesis. Role of genetic factors in the etiopathogenesis of selected diseases of the oral cavity Author. Petra Bořilová Linhartová Brno 2014 Abstract Background. Genetic factors play an important role in the etiopathogenesis of many diseases affecting the oral cavity. Genetic analysis of candidate loci was conducted in the most common oral diseases: dental caries, periodontitis in patients with/without diabetes mellitus and root resorption (EARR) after orthodontic treatment. Methods. The thesis comprises a set of eight studies (six already published articles and two articles submitted for review) and two unpublished manuscripts prepared for submitting. With the exception of one systematic review, all articles were designed as case-control studies. Genetic analysis was based on the polymerase chain reaction principle (PCR). Results. While the genetic determination of dental caries did not confirm a significant association between single nucleotide polymorphism (SNP) in the lactotransferrin gene and caries development and/or severity, allele 2 in interleukin-1 receptor antagonist (IL-1RN) proved to be a risk for EARR in girls (P=0.02). No significant associations between alleles, genotypes or haplotypes of the selected SNPs in the IL-18 gene and chronic periodontitis were found; similarly...
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Role of genetic factors in the etiopathogenesis of selected diseases of the oral cavity
Bořilová Linhartová, Petra
Dissertation thesis. Role of genetic factors in the etiopathogenesis of selected diseases of the oral cavity Author. Petra Bořilová Linhartová Brno 2014 Abstract Background. Genetic factors play an important role in the etiopathogenesis of many diseases affecting the oral cavity. Genetic analysis of candidate loci was conducted in the most common oral diseases: dental caries, periodontitis in patients with/without diabetes mellitus and root resorption (EARR) after orthodontic treatment. Methods. The thesis comprises a set of eight studies (six already published articles and two articles submitted for review) and two unpublished manuscripts prepared for submitting. With the exception of one systematic review, all articles were designed as case-control studies. Genetic analysis was based on the polymerase chain reaction principle (PCR). Results. While the genetic determination of dental caries did not confirm a significant association between single nucleotide polymorphism (SNP) in the lactotransferrin gene and caries development and/or severity, allele 2 in interleukin-1 receptor antagonist (IL-1RN) proved to be a risk for EARR in girls (P=0.02). No significant associations between alleles, genotypes or haplotypes of the selected SNPs in the IL-18 gene and chronic periodontitis were found; similarly...
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