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Experimental myocardial damage affected the administration of D-penicillamine. Blažková, Edita ; Semecký, Vladimír (advisor) ; Vopršalová, Marie (referee) Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Edita Blažková Supervisor: doc. RNDr. Vladimír Semecký, CSc. Title of thesis: Experimental myocardial damage affected the administration of D-penicillamine D-penicillamine is a substance with a wide range of use for the treatment of various diseases, especially Wilson's disease. This standard chelator is known for its ability to bind copper nonspecifically. The first aim of the thesis was to describe in detaile histopathological changes of the myocardium exposed to the effect of catecholamine, namely isoprenaline and to compare these changes with the structure of control group myocardium. The main aim was to verify potentially cardioprotective effect of D-penicillamine on the model of catecholamine induced damage. The description of histological changes complements the extensive results of in vitro and in vivo analysis. The experiment was performed on adult male Wistar Han rats, which were divided into six groups. The first group was used as a control and only received saline, the second one and third one received D-PA alone at doses of 11 and 44 mg.kg-1 . The fourth group received only ISO in a single dose of 100 mg.kg-1 . The fifth and sixth groups were premedicated... Detailed record

See also: similar author names
23	BLAŽKOVÁ, Eva
1	Blažková, Eliška
23	Blažková, Eva

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