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National Repository of Grey Literature 1 records found  Search took 0.01 seconds. 
Microscopic study of multifunctional drug molecule adhesion to electronic biosensors coated with diamond and gold nanoparticles
 Finsterle, T. ; Pilarčíková, I. ; Bláhová, I.A. ; Potocký, Štěpán ; Kromka, Alexander ; Ukraintsev, Egor ; Nepovimová, E. ; Musílek, K. ; Kuča, K. ; Rezek, B.
The easy and fast detection of drug content and concentration levels is demanded in biological research as well as in clinical practice. Here we study on microscopic level how nanodiamonds and gold nanoparticles interact with a multifunctional drug molecule directly on a biosensor surface. The sensors are made of interdigitated Au electrodes coated by 5 nm hydrogenated or oxidized nanodiamonds and further combined with Au colloidal nanoparticles (size 20 nm) providing nanoscale composite (spacing 100 nm). Atomic force microscopy is employed to measure local tip-surface adhesion forces and surface topography. AFM adhesion maps show that the drug binds to all types of nanoparticles and the adhesion is also significantly influenced by the substrates on which the nanoparticles are deposited. Role of local AFM tip interaction with nanostructured surface is also discussed.\n
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