National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Contrast enhancement for tissue discrimination and contrast nanoparticle detection by MRI
Bačovský, Jaromír ; Macíček, Ondřej (referee) ; Starčuk, Zenon (advisor)
Magnetic resonance imaging is a routine and powerful diagnostic technique capable of providing detailed information about the structure and composition of the tissues. This diploma thesis is concerned with the mechanisms of contrast origin and contrast modifications by molecular and nanoparticle contrast agents. First sections of the thesis summarize basic knowledge about pulse sequences and it aims to provide an overview on MRI contrast agent with a special emphasis on paramagnetic gadolinium contrast agents and superparamagnetic nanoparticles. The main purpose of this study is to develop the software called MRICalc, which is able to optimize contrast in MRI images. Based on analysis of signal formula of typical pulse sequences, MRICalc is able to propose the parameters of the pulse sequence for compartment-specific enhancement of the contrast. User chooses from the list of the samples and after calculation he obtains the values of echo time, repetition time and flip angle, all of which simultaneously seem to create the appropriate setting to enhance the contrast. MRICalc also allows to plot contrast function with respect to the chosen parameter. Software, including its graphical user interface, is designed in Python. The sample consists from solution of CuSO4 and distilled water was designed to verify the correct function of MRICalc. Sulphate represents a contrast agent. Preclinical MR system Bruker BioSpec 94/30 USR located at Institute of Scientific Instruments of the ASCR, v.v.i was used to measure contrast curve of FLASH pulse sequence, which is a typical representative of gradient echo. Results of the measurement were compared to the theoretical model provided by MRICalc.
Susceptibility weighted magnetic resonance imaging (SWI)
Bačovský, Jaromír ; Bartušek, Karel (referee) ; Starčuk, Zenon (advisor)
Susceptibility weighted magnetic resonance imaging (SWI) seems to be a very promising method usable in the diagnosis of a number of clinical and biomedical applications. Difusse axonal injuries and neurodegenerative diseases to name a few. The goal of my bachelor's thesis was to study the principal methods of magnetic resonance imaging with particular emphasis on susceptibility weighted imaging. Then use this theoretical knowledge for practical implementation of the SWI method to 4,7T/200mm NMR system located at Institute of Scientific Instruments of the ASCR, v.v.i. It was necessary to create an image calculated software, which is capable of enhancing contrast caused by magnetic susceptibility differences as they manifest themselves in local phase changes between tissues. Few basic problems had to be solved. The phase image was filtered by a high pass filter, a Phase Mask was created from adjusted image, which is generated from phase unwrapped image. To varify the SWI method, samples were designed, which have the desired magnetic properties. During the initial phase of experimenting, hen's eggs were used and then citrus fruits with nanoiron, CaCl2, Zn and AgCl. We investigated basic parametres and settings of the MRI measurements that affect final susceptibility weighted image.

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2 Bačovský, Jan
3 Bačovský, Jaroslav
1 Bačovský, Jiří
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