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Oscillometric blood pressure measurement
Benešová, Lenka ; Janoušek, Oto (referee) ; Šikner, Tomáš (advisor)
The bachelor thesis deals with the implementation of an oscillometric blood pressure measurement method in LabVIEW. It presents the research of blood pressure measurement methods focusing on an oscillometric method. It describes the study of different methods of measuring the systolic and diastolic blood pressure from an oscillometric curve and the implementation of two of these methods in LabVIEW. The accuracy of the implementation was verified with an auscultation technique on 37 measured subjects.
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Analysis of pulse wave velocity variability
Benešová, Lenka ; Kozumplík, Jiří (referee) ; Svačinová, Jana (advisor)
This diploma thesis deals with the variability of pulse wave velocity. It studies the variability of cardiovascular signals. It presents the research of measurement of pulse wave velocity and its analysis in physiology and pathological physiology. Applies spectral analysis in Matlab to a data set. It evaluates and reviews the results of this analysis
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Development of electroanalytical methods for detection of cholesterol, 7-dehydrocholesterol and cholecalciferol
Benešová, Lenka
Steroidival substances are an integral part of the human organism, such as bile acids, steroid hormones, vitamins. The most important sterol in whole organism is cholesterol, which is cornerstone of the all cell membranes. It is involved in important processes in the body, but its storage in blood vessels in the formo f low-density lipoprotein (LDL) is crucial of reason serious health diseases as atherosclerosis, myocardial infarction and others. 7-dehydrocholesterol is a precursor of cholesterol and another sterol compound studied by me, cholekalciferol, also known as a vitamin D3. Deficiency of 7-dehydrocholesterol reductase is the main indicatior of the possible genesis of Smith-Lemli-Opitz syndrome. One of the goals of this thesis was developed a suitable electrochemical method to facilitate the diagnosis of this syndrome from plasma and amniotic fluid in the prenatal and postnatal phases of pregnancy. Within the framework of this thesis were developer electrochemical methods in a batch and flow arrangement for detection of the above-mentioned sterols, namely cholesterol, 7-dehydrocholesterol and cholekalciferol. It was wokered in the medium contain perchloric acid or its salt sodium perchlorate in acetonitrile as supporting electrolyte. It was worked in the wide range of working disc...
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Development of electroanalytical methods for detection of cholesterol, 7-dehydrocholesterol and cholecalciferol
Benešová, Lenka ; Schwarzová, Karolina (advisor) ; Navrátil, Tomáš (referee) ; Šelešovská, Renáta (referee)
Steroidival substances are an integral part of the human organism, such as bile acids, steroid hormones, vitamins. The most important sterol in whole organism is cholesterol, which is cornerstone of the all cell membranes. It is involved in important processes in the body, but its storage in blood vessels in the formo f low-density lipoprotein (LDL) is crucial of reason serious health diseases as atherosclerosis, myocardial infarction and others. 7-dehydrocholesterol is a precursor of cholesterol and another sterol compound studied by me, cholekalciferol, also known as a vitamin D3. Deficiency of 7-dehydrocholesterol reductase is the main indicatior of the possible genesis of Smith-Lemli-Opitz syndrome. One of the goals of this thesis was developed a suitable electrochemical method to facilitate the diagnosis of this syndrome from plasma and amniotic fluid in the prenatal and postnatal phases of pregnancy. Within the framework of this thesis were developer electrochemical methods in a batch and flow arrangement for detection of the above-mentioned sterols, namely cholesterol, 7-dehydrocholesterol and cholekalciferol. It was wokered in the medium contain perchloric acid or its salt sodium perchlorate in acetonitrile as supporting electrolyte. It was worked in the wide range of working disc...
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Voltammetric detection of stigmasterol at boron-doped diamond electrode in mixed media
Benešová, Lenka ; Schwarzová, Karolina (advisor) ; Nesměrák, Karel (referee)
V o l t a m m e t r i c d e t e c t i o n o f s t i g m a s t e r o l a t b o r o n d o p e d d i a m o n d e l e c t r o d e i n m i x e d m e d i a L e n k a B e n e š o v á Univerzita Karlova v Praze Přírodovědecká fakulta Praha 2015 Abstract The aims of the study thesis was to suggest suitable solvent for oxidation of stigmasterol on boron doped diamond electrode. Cyclic voltammetry in mixed media of water and organic solvents was used for this purpose. First of all, the effect of organic solvent on potential window of boron doped diamond electrode was studied. Solvents used were methanole, isopropanole, N-dimethylformamide and acetonitrile; the water components was phosphate buffer (0,075 mol.l-1, pH 3,0). It was deduced from the results, that suitable solvent for detection of stigmasterol on was the acetonitrile, which provided sufficiently large potential window in anodic area. Keywords: boron doped diamond electrode, cyclic voltammetry, organic solvent, oxidation, stigmasterol
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Analysis of pulse wave velocity variability
Benešová, Lenka ; Kozumplík, Jiří (referee) ; Svačinová, Jana (advisor)
This diploma thesis deals with the variability of pulse wave velocity. It studies the variability of cardiovascular signals. It presents the research of measurement of pulse wave velocity and its analysis in physiology and pathological physiology. Applies spectral analysis in Matlab to a data set. It evaluates and reviews the results of this analysis
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The roots of motivation of users of quantified self
Benešová, Lenka ; Fiala, Jakub (advisor) ; Lipková, Helena (referee)
Subjects of this thesis are the quantified self and user motivation. This paper aims to determine what brings users to the self-tracking lifestyle as well as what devices they use and why. In the theoretical part of the paper types of self-tracking devices, their potential uses in various aspects of life and the ways they communicate with users are described. In the practical part of the paper results of a small-scale user study are presented. The objective of this study was to identify what motivates the users participating in the study to self-track. The theoretical part of the paper may serve as an introduction to quantified-self while the results presented in the practical part may be used for further, more in-depth, research.
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Development of electroanalytical methods for detection of cholesterol and 7-dehydrocholesterol
Benešová, Lenka ; Schwarzová, Karolina (advisor) ; Dejmková, Hana (referee)
The aim of this Thesis is development of electroanalytical methods for determination of cholesterol and 7-dehydrocholesterol on boron doped diamond electrodes based on electrochemical oxidation of products of acid-induced dehydration reaction. Two approches have been applied, relying on their detection in 0,1 mol.l-1 perchloric acid in acetonitril containing variable water content 0,43 % - 40 %. Cyclic voltammetry revealed substantial difference in oxidation peak pontecials for 7-dehydrocholesterol (+850 mV) and cholesterol (+1500 mV) in 0,1 mol.l-1 perchloric acid in acetonitrile containing 5 % of water. The limit of detection using differential pulse voltammetry were 6,19 µmol.l-1 a 19,2 µmol.l-1 for a mixture of 7-dehydrocholesterol and cholesterol, respectively. For flow injection analysis with amperometric detection (FIA-AD) the water content in run buffer, detection potencial and the distance between the capillary outlet and electrode surface in wall-jet arrangement of amerometric flow-through detection cell were optimized. Achieved detection limits are in range of 0,61 - 3,43 µmol.l-1 depending on the detection potencial and water concent in the run buffer. The developed FIA-AD method was used for determination of a model mixture solution of 7- dehydrocholesterol and cholesterol. Key words...
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