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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Preparation of fluorinated carbocyclic derivatives of nucleosides as potential viral replication inhibitors
 Štefek, Milan ; Nencka, Radim (advisor) ; Šimák, Ondřej (referee)
This master thesis is dedicated to the preparation of fluorinated derivatives of carbocyclic nucleosides, that may serve as flaviviral replication inhibitors. Preparation of both monofluorinated as well as gem-difluorinated analogs of ribo and 2'-deoxyribonucleoside was attempted. While a suitable and reliable route for the preparation of monofluorinated compounds way found, synthesis of gem-difluorinated turned out to be rather challenging. Although most of the presented work dealt with compounds bearing adenine as a nucleobase, the universal applicability of the developed procedures, demonstrated on the preparation of a guanosine-type molecule, suggests that after slight optimization larger series of this type of compounds could be prepared.
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Synthesis of novel prodrugs for antiviral therapy
 Štefek, Milan ; Nencka, Radim (advisor) ; Janeba, Zlatko (referee)
This bachelor thesis is dedicated to preparation of prodrugs derived from 2'-C- methyladenosine, which is a potent inhibitor of the RNA dependent RNA polymerase of flaviviruses. Prodrugs modifying 3' and 5' hydroxy groups able to deliver the drug to brain and were prepared. As targeting moieties tropine and the redox system trigonelline/1,4- dihydrotrigonelline were used. In the case of tropine a suitable method for the preparation of prodrugs was developed. Reliable procedure for performing the last step of synthesis of compounds utilizing the trigonelline redox system is yet to be discovered.
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See also: similar author names
2 ŠTEFEK, Marcel
11 Štefek, Martin
2 Štefek, Michal
2 Štefek, Miroslav
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