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National Repository of Grey Literature

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Purinové báze a nukleosidy nesoucí funkcionalizované C-substituenty v pozici 6. Syntéza a biologická aktivita Hocek, Michal ; Šilhár, Peter ; Kuchař, Martin ; Hasník, Zbyněk ; Bambuch, Vítězslav Purine bases and nucleosides bearing diverse functionalized C-substituents have been prepared either via cross-coupling reactions of 6-halopurines with protected functionalized organometallic reagents or via conjugate additions of nucleophiles to 6-vinyl- or 6-ethynylpurines. Other types of substituents have been prepared by further functional group transformations of 6-(mesyloxymethyl)purines. Systematic biological activity screening revealed several new types of cytostatic and anti-HCV purine nucleosides. Detailed record

Syntézy a transformace 6-(hydroxymethyl)purinů Šilhár, Peter ; Pohl, Radek ; Votruba, Ivan ; Hocek, Michal 6-(Hydroxymethyl)purines were prepared by cross-coupling reactions of ž-halopurines with acyloxymethylzinc and were subsequently transformed to 6-(fluoromethyl)purines. Detailed record

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