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Brno City Hospital
Seďa, Ondřej ; Hybská, Bohumila (referee) ; Sedláček, Michal (advisor)
The topic of the diploma thesis is the design of a town hospital at Kraví hora in Brno. The design of the new city hospital in Brno replaces the functions of two existing city hospitals, the Merciful Brothers Hospital and the Trauma Hospital, whose technologies do not meet the medical requirements of the 21st century. In the hospital there are standard facilities, namely outpatient medical facilities, including day hospitals, central blood collection, emergency, operating rooms, central sterilization, anesthesiology and resuscitation departments, intensive care units, maternity and neonatology departments, examination complement , laboratories, rehabilitation departments, inpatient departments of surgical and internal medicine, non - medical and commercial premises, personnel background, technical background and parking. The hospital is a 10-storey building. The main idea of the design was to create a hospital with the views of the park even Brno skyline.
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Aircraft design regulations
Seďa, Ondřej ; Pešák, Miroslav (referee) ; Píštěk, Antonín (advisor)
Baccalaureate work includes set of regulatins needs for aircraft construction. Out of printed are caregory qualification and using after european regulations CS, american regulations FAR and regulations for ultra-light aeroplanes. Mentioned are also regulations for operation and pilots training.
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Modification of RAPID 200 Aircraft for Towing
Seďa, Ondřej ; Daněk, Vladimír (referee) ; Píštěk, Antonín (advisor)
This master’s thesis deal with design modification of the RAPID 200 (Skyleader 200) airplane for towing at compliance with maximum take-off weight 450 kilogramme. A necessary construction modification, a weight analysis these adjustments and a balance verification are included. The thesis contains of power plants installation consisting from the M 132 engine and the V 541.2 propeller, a towing gear and a landing gear, a load calculation of power plants and towing gear and basic flight performance calculation too. Last but not least valuation of operation ekonomy, operation characteristics assesment and a using of the airplane for specialized duty are included.
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Berkova Residence
Seďa, Ondřej ; Šubrt, Jan (referee) ; Dulenčín, Juraj (advisor) ; Jelínek, Petr (advisor)
The topic of the bachelor thesis is a design of Berkova Residence. The building plot is situated in the corner of the streets Berkova and Bulharská in Královo Pole. The residence has 6 storeys. In the residence there is a big variety of flats, 2 maisonettes, common areas – an underground garage, the cellar cubicles, garden, a place for storage bikes, baby carriages and wheelchairs, an exterior entrance hall with mailboxes and staircase core with a design facade.
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Nutrigenetic analysis of metabolic syndrome: the role of spontaneously hypertensive rat chromosome 4
Petrů, Karolína ; Šeda, Ondřej (advisor) ; Malínská, Hana (referee)
Metabolic syndrome (MetS) is a complex condition with a number of interacting genes, epigenetic and environmental factors underlying its pathogenesis. The analysis of genetic component of MetS showed that number of defining parameters of the syndrome is linked to regions of rat chromosome 4. In order to verify these quantitative trait loci (QTL), a double congenic strain was derived with parts of chromosome 4 of spontaneously hypertensive rat (SHR, an inbred MetS model) origin introgressed onto genomic background of congenic Brown Norway strain (BN-Lx). The aim of the proposed thesis is comprise detail genetic mapping of differential segments of the above mentioned double congenic strain BN-Lx.SHR4 and comparison of its metabolic profile under different dietary conditions with varying carbohydrate and fat content. Utilizing DNA sequence and gene expression comparisons, candidate genes or polymorphisms for the MetS aspects and potential nutrigenetic interactions will be identified. Key words: nutrigenetics, experimental models, metabolic syndrome, congenic strain, genotyping, rat
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Brno City Hospital
Seďa, Ondřej ; Hybská, Bohumila (referee) ; Sedláček, Michal (advisor)
The topic of the diploma thesis is the design of a town hospital at Kraví hora in Brno. The design of the new city hospital in Brno replaces the functions of two existing city hospitals, the Merciful Brothers Hospital and the Trauma Hospital, whose technologies do not meet the medical requirements of the 21st century. In the hospital there are standard facilities, namely outpatient medical facilities, including day hospitals, central blood collection, emergency, operating rooms, central sterilization, anesthesiology and resuscitation departments, intensive care units, maternity and neonatology departments, examination complement , laboratories, rehabilitation departments, inpatient departments of surgical and internal medicine, non - medical and commercial premises, personnel background, technical background and parking. The hospital is a 10-storey building. The main idea of the design was to create a hospital with the views of the park even Brno skyline.
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Low carbohydrate diet in type 2 diabetes mellitus therapy
Kábelová, Adéla ; Krejčí, Hana (advisor) ; Šeda, Ondřej (referee)
Type 2 diabetes mellitus (T2D) is a highly prevalent metabolic disorder, which substantially affects quality of patients' lives and simultaneously increases the risk of early death due to development of its specific complications. Current T2D therapy comprises mainly pharmacotherapy, however, lifestyle changes, particularly modification of dietary habits, also assume an important role in the process. While conventional dietotherapy of T2D primarily concerns reduction of dietary fat intake aiming to achieve caloric restriction, the low carbohydrate diet (LCD), recently often discussed in relation to T2D therapy, is based on the reduction of dietary carbohydrates, whereas fats and/or proteins are increased. The positive effects of LCD in T2D therapy and its comorbidities are summarized in the theoretical part of this thesis. The aim of the practical part of the bachelor thesis was to asses the effect of LCD on health parameters associated with T2D as well as the subjective sense of respondents' satisfaction with this diet together with their adherence and compliance. The results of the survey showed that LCD led to weight loss, decreased waist circumference, glycaemia and levels of glycated haemoglobin and led, in a number of cases, to medication reduction. The level of satisfaction with LCD in the...
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Pharmacogenetics of peroral antidiabetics
Sichingerová, Ema ; Šeda, Ondřej (advisor) ; Včelák, Josef (referee)
Diabetes mellitus is a summarizing term for chronic metabolic diseases characterized by long- lasting hyperglycemia. The incidence of type 2 diabetes mellitus is rising worldwide, with the predominant characteristics of a global epidemic in recent years. Treatment of diabetes comprises, among other means, oral antidiabetics, whose function and incidence of side effects can also be influenced by genetic factors. Pharmacogenetics, a field on the border between pharmacology and genetics, deals with such interactions. Pharmacogenetic knowledge helps with drug development and deepens the understanding of the physiological causes of the disease, emphasizing the individuality of the patient. This thesis aims to summarize the pharmacogenetic interactions described in the most used oral antidiabetics so far and their mechanisms of action. Key words: pharmacogenetics, diabetes, gene-environment interactions, single nucleotide polymorphisms
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Mechanisms of apoptosis induction and inhibition by fatty acids in pancreatic β-cells
Šrámek, Jan ; Kovář, Jan (advisor) ; Brunerová, Ludmila (referee) ; Šeda, Ondřej (referee)
Recently, diabetes mellitus type 2 (DMT2) represents one of the most important metabolic diseases according to its incidence and economic impacts. One of the main reasons of this diesease is loss of function and viability of pancreatic β-cells due to the effect of increased levels of saturated fatty acids (FAs). Unsaturated FAs are better tolerated by β-cells. They are even capable of inhibiting detrimental effects of saturated FAs. Molecular mechanisms of apoptosis induction in pancreatic β-cells by saturated FAs as well as mechanisms of inhibition of this induction by unsaturated FAs are not completely elucidated. The main aim of this study was to contribute to elucidation of these mechanisms. Concerning human pancreatic β-cell line NES2Y we demonstarted: (1) Activation of caspase-2 by stearic acid (SA), in apoptosis inducing concentration (1 mM), is not crucial for the process of apoptosis induction. However, this caspase modulates SA-induced endoplasmic reticulum (ER) stress pathways. (2) SA (1 mM) activates the p38 MAPK signaling pathway and inhibits the ERK signaling pathway. Inhibition of the ERK signaling pathway is probably a consequance of the p38 MAPK pathway activation. However, p38 MAPK is not very likely crutial for the apoptosis induction by SA. Unsaturated oleic acid (OA, 0.2 mM) is able to...
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Molecular mechanisms of LDL-cholesterol induced endothelial dysfunction
Rojková, Tereza ; Petrezsélyová, Silvia (advisor) ; Šeda, Ondřej (referee)
Hypercholesterolemia, defined as elevated LDL-cholesterol levels in the blood, develops either as a result of genetic predispositions, unhealthy lifestyle, underlying diseases, or as a result of a combination of these factors. LDL-cholesterol is sometimes called "bad" cholesterol because its excess negatively affects the vessel`s innermost layer - endothelium, Endothelium is unique for its vasodilatory, vasoconstrictive, anti-inflammatory, and anti- coagulant function but also for its ability to control vascular permeability. In the case of hypercholesterolemia, cholesterol gradually accumulates in the subendothelial space and reduces levels of the main modulatory molecule of the endothelium - nitric oxide by several mechanisms. In endothelial dysfunction, oxidative stress increases, LDL-cholesterol is oxidized, endothelial cells are activated and produce proinflammatory cytokines and adhesive molecules. Endothelial dysfunction is considered the first stage of atherosclerosis, as monocytes enter the site of inflammation and differentiate into macrophages, which subsequently turn into foam cells by endocytosis of oxidized LDL-cholesterol. In this way, atherosclerotic plaques are formed, which not only narrow the blood vessels, but plaques can erupt, causing subsequent thrombosis, which can result...
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