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The Current Issue on Monoclonal Gammopathy of Undetermined Significance from the Perspective of Regional Biochemical Laboratory
Šolcová, Lucie ; Maisnar, Vladimír (advisor) ; Pour, Luděk (referee) ; Kušnierová, Pavlína (referee)
3. Summary This thesis deals with the issue of MGUS from the perspective of the regional biochemical laboratory. The dissertation thesis is divided into several chapters. The first part includes general knowledge about monoclonal gammopathies, their basic distribution and characteristics of individual types of monoclonal gammopathies. The next chapter is focused on monoclonal gammopathy of uncletermined significance and their epidemiology, etiology and pathogenesis, disease prevalence, diagnostics and diagnostic criteria. The clinical course of MGUS, prognostic factors and monitoring of monoclonal gammopathy activity are also mentioned. The importance of determining free light chains for the stratification of MGUS risk is also presented separately. The next chapter deals with the basic methods of laboratory diagnostics of MGUS and their pitfalls. The chapter also contains a discussion of the SEKK control system and standardization. The next chapter is devoted to new directions in the diagnosis of monoclonal gammopathies, namely determination of light / heavy chain pairs (Hevylite), immunophenotyping examination, genome examination. In the second part of the dissertation are recorded individual observations of individual cases of monoclonal gammopathies. It includes own laboratory monitoring of individual...
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Analýza invazivní schopnosti a infekčního potenciálu nově popsaných druhů borelie z komplexu \kur{Borrelia burgdorferi} sensu lato, \kur{B. americana} a \kur{B. carolinensis} na laboratoním modelu infikovaných savců
ŠOLCOVÁ, Lucie
The aim of the study was to analyze the infectious potential of the newly described species, B. americana and B. carolinensis, studied on the laboratory model mammals mice. Our goal was to analyze and compare the vectorial capacity of two different tick vectors, Amblyomma americanum and Ixodes ricinus, in acquiring and transmition of both spirochete species to the host. The results of this study confirmed that ticks A. americanum and I. ricinus are capable to maintain and transmit B. americana and B.carolinensis.We confirmed that both analysed spirochete species, B. carolinensis and B. americana, showed the potential to develop the disease in laboratory model mammal, which indirectly support the fact that both spirochete species might be concidered as the risk factors in the area where they are distributed. Our results shows that A. americanum is able to transmit both spirochete species, which increases that risk of acquiring the Lyme disease to human population in the area of distribution of A. americanum
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Mating systems cryptically living mammals with a focus on underground mammals
ŠOLCOVÁ, Lucie
Mating systems describe how are animals paired and with how many sexual partners reproduce. In my study, I have reviewed different mating systems in vertebrates and methods how to assess mating systems in mammals. I focused mainly on genetic methods, because they provide the most reliable tool in assessing mating systems of a particular species. Special interest is devoted to mating systems of mammals with cryptic activity such as subterranean rodents. I also tested the methodology of microsatellite analysis for further study on genetic relationships across the population and mating system of the blind mole rat (Spalax galili) from Israel.
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