Home > Search Results: Šůsová, Karolína
Search:
Search Tips :: Advanced Search
Search collections:
Sort by: Display results: Output format:
National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Significance of genetic factors for prognosis and prediction of cancer therapy outcome.
 Šůsová, Karolína ; Wsól, Vladimír (advisor) ; Malátková, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Karolína Šůsová Supervisor: Prof. Ing. Vladimír Wsól, Ph.D. Title of diploma thesis: Significance of genetic factors for prognosis and prediction of cancer therapy outcome Colorectal cancer (CRC) is one of the most common cancers in the world and also in the Czech Republic. There are many reasons for such a high prevalence and mortality. In general, we can say, that the level of awareness of risk factors and primary prevention is very low. For example, the inoperability of the tumor, caused by the diagnosis of CRC at a late stage, makes therapy of patients difficult and reduces survival. 5 - Fluorouracil and leucovorin are the gold standard in the treatment of CRC. The targeted therapy has a great success in the palliative therapy and prolongs survival. However, many patients do not respond to adjuvant and palliative therapy well. This failure is often caused by drug resistance. Efflux of cytotoxic drugs out of cells caused by transport proteins of cancer cells. ABC transporters remain among the many elements of drug resistance. Deregulation of gene expression of ABC transporters in tumor cells was discovered in connection with other types of cancer. The aim of this study is to find...
Detailed record
Significance of genetic factors for prognosis and prediction of cancer therapy outcome.
 Šůsová, Karolína ; Wsól, Vladimír (advisor) ; Malátková, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Karolína Šůsová Supervisor: Prof. Ing. Vladimír Wsól, Ph.D. Title of diploma thesis: Significance of genetic factors for prognosis and prediction of cancer therapy outcome Colorectal cancer (CRC) is one of the most common cancers in the world and also in the Czech Republic. There are many reasons for such a high prevalence and mortality. In general, we can say, that the level of awareness of risk factors and primary prevention is very low. For example, the inoperability of the tumor, caused by the diagnosis of CRC at a late stage, makes therapy of patients difficult and reduces survival. 5 - Fluorouracil and leucovorin are the gold standard in the treatment of CRC. The targeted therapy has a great success in the palliative therapy and prolongs survival. However, many patients do not respond to adjuvant and palliative therapy well. This failure is often caused by drug resistance. Efflux of cytotoxic drugs out of cells caused by transport proteins of cancer cells. ABC transporters remain among the many elements of drug resistance. Deregulation of gene expression of ABC transporters in tumor cells was discovered in connection with other types of cancer. The aim of this study is to find...
Detailed record

See also: similar author names
3 Susová, Kateřina
6 SŮSOVÁ, Kristýna
6 Sůsová, Kristýna
Interested in being notified about new results for this query?
Subscribe to the RSS feed.
Digital Repository :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.2
Maintained by admin.invenio@techlib.cz
This site is also available in the following languages:
Česky  English