|
| |
|
| |
|
|
Analysis of vaccine utilization and spontaneous adverse events reports in influenza vaccine
Podskalská, Markéta ; Zimčíková, Eva (advisor) ; Kolmanová, Eliška (referee)
Analysis of vaccine utilization and spontaneous adverse events reports in influenza vaccine Author: Markéta Podskalská Supervisor: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and goal: Influenza is a contagious disease of the respiratory system. It is caused by influenza viruses and appears in annual outbreaks. The best form of influenza prevention is vaccination against influenza viruses on yearly basis. The vaccination has many benefits, but some side effects may appear as well. Goal of this thesis was to analyse and evaluate reports of side effects of influenza vaccination between years 2004-2017 and to evaluate the use of influenza vaccines from 2004 to 2022. Methodology: The Central Database of Adverse Events Reporting of the State Institute for Drug Control was used as the data source. Reports with the ATC code J07BB in the period from 2004 to 2017 were evaluated. Information about the patient, reporting person, the region where the notification was filed, the method of reporting and details concerning adverse events were analysed. These details included the number and severity of adverse effects, their predictability and final outcome. Data on influenza vaccine usage were provided by SÚKL....
|
|
|
Follow-up of patiens after COVID-19 monoclonal antibodies administration
Minaříková, Jiřina ; Zimčíková, Eva (advisor) ; Hendrychová, Tereza (referee)
Follow-up of patients after COVID-19 monoclonal antibodies administration Author: Jiřina Minaříková Supervisor: PharmDr. Eva Zimčíková, Ph.D. Consultant: PharmDr. Petra Rozsívalová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Keywords: COVID-19, coronavirus, monoclonal antibodies, casirivimab and imdevimab, REGN-COV2 Introduction: At height of COVID-19 pandemic surge of Delta variant, monoclonal antibodies became a vital treatment option for SARS-CoV-2 positive outpatients at high risk of severe disease progression. Casirivimab and imdevimab (C/I) were used as an unauthorised medicinal product REGN-COV2 under European Medicines Agency emergency use authorisation (EUA). There was paucity of real-world data on safety and effectiveness. Objective: The study aimed to describe REGN-COV2 drug safety, self-reported symptom burden in SARS-CoV-2 positive outpatients within 90 days post C/I infusion. Methods: Prospective multicentric study of SARS-CoV-2 positive outpatients with mild symptoms at high-risk of severe COVID-19 progression (defined criteria under EUA authorization for C/I ambulatory administration) was conducted from September 2021 till April 2022 in three teaching hospitals in Czech Republic and Slovakia. The data collected...
|
|
|
Analysis of pharmacotherapy in patients in the hospice
Sládek, Jakub ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of pharmacoterapy hospice care patients Author: Jakub Sládek Tutor: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and purpose: The therapy of hospice care patients is accompanied by many changes and pitfalls that need to be balanced when choosing appropriate therapy. In the teoretic part we can find available information about paliative therapy of hospice care patients, with emhasis on pain therapy. The aim of this thesis is the analysis of pharmacotherapy hospice care patients. Methods: The data were collected in a hospice from September 2019 to November 2019. The farmacotherapy was revised every first day of the month. Informations from personal, drug, family and occupational social history of patients were noted into an electronic database and, after revision, were classified and evaluated by frequency analysis. In four randomly selected patients was described the management of drug-related problems (DRP). Results: In total we noted medical therapy in 40 patients, women were 75 % of this number. Average patient's age was 72.4 years for men and 74.6 for women. Patients most often used drugs from group N (drugs of the nervous system) according to the ATC classification. We indentified 115...
|
|
|
Analysis of the effect of pharmacotherapy on the risk of fall in inpatients III
Honsová, Tereza ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of the effect of pharmacotherapy on the risk of falls in inpatents III Author: Tereza Honsová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Falls are frequent and unwanted events happening in healthcare facilities. The falls have a multifactorial character. The prevention is the best way how to improve a quality of healthcare and a quality of the patient's life. All of the doctors, clinical pharmacists and nurses can help to realize it by cooperating with each other, working with professional information and by individual attitude to each patient. Objective: The aim of this study was to analyze the effect of the fall risk-increasing drugs to falls in hospitalized patients and to recommend the right interventions to prevent the fall. Methodology: For the analysation, classification and quantification of the fall risk-increasing drugs, drug related problems and interventions a special online database was created. All of the doctors, clinical pharmacists and nurses were collecting details about the pacients and about how the fall happened. Fall risk-increasing drugs and drug-related problems were then analyzed by clinical pharmacists. Potential interventions were suggested. Also other...
|
|
|
Analysis of utilisation and spontaneous adverse events reports related to human papillomavirus vaccines
Schrommová, Tereza ; Zimčíková, Eva (advisor) ; Kolmanová, Eliška (referee)
Analysis of utilisation and spontaneous adverse events reports related to human papillomavirus vaccines Author: Tereza Schrommová Supervisor: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University INTRODUCTION: HPV vaccination is one of the most effective types of prevention against the human papillomavirus infection that can lower the probability of its incidence up to 80-90 %. Besides the benefits of vaccination, there can also occur among many individuals certain risks and adverse effects. Spontaneous adverse events reports are used to identify these serious and unexpected adverse effects, their monitoring leads to increasing safety of therapy. Drug consumption is monitored to uncover the ratio of population exposure to certain drug during specific time in specific socioeconomic group. OBJECTIVE: The objective of this diploma was analysis of spontaneous adverse events reports of vaccines against the human papillomavirus that are registered in database of State Institute for Drug Control in the period from May 2007 to October 2017. Another aim of this work was to evaluate consumption of HPV vaccines in the Czech Republic in the period from 2006 to 2019 using data from State Institute for Drug Control again. METHODS:...
|
|
|
The referral procedure as a tool for influence the regulatory status of medicinal product in EU.
Závodská, Gabriela ; Zimčíková, Eva (advisor) ; Fuksa, Leoš (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Mgr. Gabriela Závodská Consultant: PharmDr. Eva Zimčíková, Ph.D. Title of Thesis: The referral procedure as a tool for influence the regulatory status of medicinal product in EU. The referral procedure is very important possibility how the medical agencies in EU can influence the regulatory status of a medical product - change, suspend or revoke the registration. Our first aim was to describe the referral procedures defined in "The rules governing medicinal products in the European Union" - reasons for initiation, course and possible outcomes. One chapter deals with procedures concerning risk of venous and arterial thromboembolism in users of combined hormonal contraceptive. Our second aim was to observe the number of procedures during 2005-2014. We were interested in reason for initiation and outcomes of some procedures. We observed an increase in the number of procedures which are initiated from safety reasons on the basis of pharmacovigilance data.
|
|
|
Analysis of Anticoagulant Utilization in the Czech Republic in the period from 2007 to 2016
Hochelová, Zuzana ; Zimčíková, Eva (advisor) ; Malý, Josef (referee)
Analysis of anticoagulant utilization in the Czech republic in the period from 2007 to 2016 Author: Zuzana Hochelová1 Supervisor: PharmDr. Eva Zimčíková, Ph.D.1 Consultant: PharmDr. Kateřina Malá, Ph.D.1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Anticoagulants are drugs that reduce blood clotting and prevent the formation of blood clots. In the Czech Republic - antagonists of vitamin K-warfarin, direct oral inhibitors of factor Xa-rivaroxaban, apixaban, edoxaban, direct oral inhibitors trombin - dabigatran, parenteral anticoagulants - heparin, low-molecular heparin, fondaparinux, oral and parenteral hirudin are used. Objective: The objective of this diploma thesis was to assess the consumption of oral and parenteral anticoagulants in the Czech Republic from 01. 01. 2007 to 31. 12. 2016, based on the data from the State Institute of Drug Control (SIDC). Methods: ATC/DDD methodology was applied. The research consisted of a retrospective analysis of the SIDC database. All oral and parental anticoagulants approved in the CR were included in the study. Drug utilization was calculated as number of defined daily doses per thousands of inhabitants per day (DID). The data on the number of residents was acquired from...
|
|
|
Use of inhaled drugs in obstructive pulmonary diseases
Obertová, Nikola ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Use of inhaled drugs in obstructive pulmonary diseases Author: Nikola Obertová 1 Tutor: Josef Malý 1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objectives: Chronic respiratory diseases are emerging health problem. The administration of the medication is mostly performed by the process of inhalation. Therefore, a proper inhalation technique plays a crucial role in symptom reduction and achievement of adequate control over the disease. The aim of the thesis was partly to assess the level of inhalation technique in elderly patients in nursing home settings, partly to evaluate the knowledge of nurses and their role in advice provision related to the proper inhalation technique. Methods: The data were collected from June to September 2016 from 18 nursing homes located in South Wales (Great Britain). The study was realized in two arms. The evaluated group (first arm) was composed of patients (residents) with having asthma bronchiale or chronic obstructive pulmonary disease diagnosed and being older than 65 years. Second arm consisted of nurses responsible for giving advices about inhalation technique to the residents. Nursing home visits were composed of three parts. First one was a controlled interview based on the...
|
guest ::
