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Following the phenotype development of TgHD minipigs by invasive and noninvasive approach
Ellederová, Zdeňka
;
Baxa, Monika
;
Vidinská, Daniela
;
Bohuslavová, Božena
;
Vochozková, Petra
;
Šmatlíková, Petra
;
Klíma, Jiří
;
Valeková, Ivona
;
Ardan, Taras
;
Juhás, Štefan
;
Juhásová, Jana
;
Konvalinková, R.
;
Klempíř, J.
;
Pokorný, M.
;
Krupička, R.
;
Kauler, J.
;
Hansíková, H.
;
Motlík, Jan
Recent promising treatments for Huntington’s disease (HD) may require pre-clinical testing in large animals. In 2009, we generated HD transgenic (TgHD) minipigs with one copy encoding the N-terminal part (548 aa) of human huntingtin (HTT) with 124 CAG/CAA repeats integrated into chromosome 1 q24-q25. The successful germ line transmission occurred through four successive generations.
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