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Mitochondrial permeability transition pore and its role in cardioprotection
Ryba, Lukáš ; Kalous, Martin (advisor) ; Brabcová, Iveta (referee)
The mitochondrial permeability transition pore (MPTP) is a non-specific voltage dependent channel which is located in the inner mitochondrial membrane. High calcium concentration and oxidative stress are main inducers of MPTP opening in a tissue which is affected by ischaemia and subsequent reperfusion. Morbidity and mortality of pacients who suffer from acute myocardial infaction or cardiochirugical operation, depends on the size of ischemic- reperfusion injury (IRI). The methods of IRI attenuation are based on the inhibition of the MPTP through farmacological intervention or ischemic conditioning. This thesis summarizes the current knowledge about the MPTP structure, regulation and its role in cardioprotection. Key words: mitochondrial permeability transition pore, cardioprotection, ischemic conditioning, CsA, SAFE and RISK pathway
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Comparison of unemployment rates of czech university graduates based on various factors
Ryba, Lukáš ; Brázdilová, Michaela (advisor) ; Vltavská, Kristýna (referee)
Observating unemployment of Czech university graduates while using different characteristics of them is a good foundation for evaluating their employability. Comparing unemployment rates between groups of students sorted for example by a study focus, type of a study program, or a gender can be valuable for evaluating actual work opportunities. Detailed analysis of the unemployment rates by different factors can also bring new knowledge regarding employment of the university graduates. Goal of this thesis is to compare the unemployment rates of the Czech university graduates by some of their key characteristics, and to evaluate the progression of aforementioned characteristics.
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Mitochondrial permeability transition pore and its role in cardioprotection
Ryba, Lukáš ; Kalous, Martin (advisor) ; Brabcová, Iveta (referee)
The mitochondrial permeability transition pore (MPTP) is a non-specific voltage dependent channel which is located in the inner mitochondrial membrane. High calcium concentration and oxidative stress are main inducers of MPTP opening in a tissue which is affected by ischaemia and subsequent reperfusion. Morbidity and mortality of pacients who suffer from acute myocardial infaction or cardiochirugical operation, depends on the size of ischemic- reperfusion injury (IRI). The methods of IRI attenuation are based on the inhibition of the MPTP through farmacological intervention or ischemic conditioning. This thesis summarizes the current knowledge about the MPTP structure, regulation and its role in cardioprotection. Key words: mitochondrial permeability transition pore, cardioprotection, ischemic conditioning, CsA, SAFE and RISK pathway
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