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A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone.
Nguyen Thi, Thu Ha ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical technology Student: Nguyen Thi Thu Ha Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone. Thesis studies the coprocessed dry binder Ludipress® , which consists of α-lactose monohydrate, polyvinylpyrrolidone and crospovidone. Ludipress® was tested in the mixture with lubricants magnesium stearate and sodium stearyl fumarate in 0,5 % and 1 % concentration and with microcrystalline cellulose in 25 % concentration. Test focused on flowability, compressibility, tensile strength and disintegration time of tablets. Compressibility was evaluated by energy profile of compression in function of compression force. Ludipress® shows high friction therefore addition of lubricant is necessary. Lubricants improved powder flowability and compressibility; 0,5 % concentration of magnesium stearate is the most suitable. Higher concentration of lubricants decreased tensile strength of tablets. Disintegration time did not increase with compression force. Tablets with 1 % concentration of sodium stearyl fumarate had the longest time of disintegration. The addition of 25 %...
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A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone.
Nguyen Thi, Thu Ha ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical technology Student: Nguyen Thi Thu Ha Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone. Thesis studies the coprocessed dry binder Ludipress® , which consists of α-lactose monohydrate, polyvinylpyrrolidone and crospovidone. Ludipress® was tested in the mixture with lubricants magnesium stearate and sodium stearyl fumarate in 0,5 % and 1 % concentration and with microcrystalline cellulose in 25 % concentration. Test focused on flowability, compressibility, tensile strength and disintegration time of tablets. Compressibility was evaluated by energy profile of compression in function of compression force. Ludipress® shows high friction therefore addition of lubricant is necessary. Lubricants improved powder flowability and compressibility; 0,5 % concentration of magnesium stearate is the most suitable. Higher concentration of lubricants decreased tensile strength of tablets. Disintegration time did not increase with compression force. Tablets with 1 % concentration of sodium stearyl fumarate had the longest time of disintegration. The addition of 25 %...
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A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone.
Nguyen Thi, Thu Ha ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical technology Student: Nguyen Thi Thu Ha Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials and tablets with the coprocessed dry binder containing lactose, povidone and crospovidone. Thesis studies the coprocessed dry binder Ludipress® , which consists of α-lactose monohydrate, polyvinylpyrrolidone and crospovidone. Ludipress® was tested in the mixture with lubricants magnesium stearate and sodium stearyl fumarate in 0,5 % and 1 % concentration and with microcrystalline cellulose in 25 % concentration. Test focused on flowability, compressibility, tensile strength and disintegration time of tablets. Compressibility was evaluated by energy profile of compression in function of compression force. Ludipress® shows high friction therefore addition of lubricant is necessary. Lubricants improved powder flowability and compressibility; 0,5 % concentration of magnesium stearate is the most suitable. Higher concentration of lubricants decreased tensile strength of tablets. Disintegration time did not increase with compression force. Tablets with 1 % concentration of sodium stearyl fumarate had the longest time of disintegration. The addition of 25 %...
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