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Energy expenditure and nutritional substrate utilization in critically ill patients.
Korvasová, Hana ; Hronek, Miloslav (advisor) ; Havel, Eduard (referee)
This thesis deals with the measurement of (resting) energy expenditure and oxidation of nutritional substrates in critically ill patients, according to variously given nutritional support. The comparison of nutritional substrate incomes followed recommendation of the ESPEN guidance. Patients were examined by indirect calorimetry. This study included 9 critically ill patients on the ventilator, of which 1 patient was spontaneously breathing. (Resting) energy expenditure and oxidation of individual nutritional substrates were determined from the measured values. Firstly, the measurements were taken on fasting patients (without nutritional support). Secondly, a low caloric nutrition (1370 296.7 kcal/day) and lastly, normocaloric nutrition (2169.802 500.926 kcal/day) were given. This study also demonstrated the inaccuracy of resting energy expenditure estimation using predictive equations (the Harris-Benedict equation specifically), compared to the measured (R)EE by indirect calorimetry. According to the results of the HB-equation, resting energy expenditure decreased with increasing nutritional support. However, indirect calorimetry values showed the opposite, namely the increase in (resting) energy expenditure with increasing nutritional support. A statistically significant difference was found...
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Energy expenditure and nutritional substrate utilization in critically ill patients.
Korvasová, Hana ; Hronek, Miloslav (advisor) ; Havel, Eduard (referee)
This thesis deals with the measurement of (resting) energy expenditure and oxidation of nutritional substrates in critically ill patients, according to variously given nutritional support. The comparison of nutritional substrate incomes followed recommendation of the ESPEN guidance. Patients were examined by indirect calorimetry. This study included 9 critically ill patients on the ventilator, of which 1 patient was spontaneously breathing. (Resting) energy expenditure and oxidation of individual nutritional substrates were determined from the measured values. Firstly, the measurements were taken on fasting patients (without nutritional support). Secondly, a low caloric nutrition (1370 296.7 kcal/day) and lastly, normocaloric nutrition (2169.802 500.926 kcal/day) were given. This study also demonstrated the inaccuracy of resting energy expenditure estimation using predictive equations (the Harris-Benedict equation specifically), compared to the measured (R)EE by indirect calorimetry. According to the results of the HB-equation, resting energy expenditure decreased with increasing nutritional support. However, indirect calorimetry values showed the opposite, namely the increase in (resting) energy expenditure with increasing nutritional support. A statistically significant difference was found...
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