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Analysis of Corporate Performance Using Mathematical Modelling and Computer System to the Support of Organization's Strategic Management
Horáková, Eva ; Švehla, Michal (referee) ; Chvátalová, Zuzana (advisor)
The main goal of this diploma thesis is to analyse financial productivity of a chosen company, to find deficiencies and suggest possibilities for improvement of the situation. First there is theoretical part consisting of an introduction of chosen financial indicators, such as profitability, indebtedness etc., and also a description of Maple, programme used for mathematical exercises. In the practical part there is a description of Brno company TRON, the business objective of which is LED lighting. The financial indocators are made in the programme Maple, the balance and also profit and loss accounts for a few consecutive years are analysed, from which we can determine the financial situation of the company. The result should help the chosen company with future decisions.
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Analysis of Business Environment
Horáková, Eva ; Šperková, Romana (referee) ; Breinek, Pavel (advisor)
This Bachelor thesis analyses the business environment. In the theoretical part the environment of the company, barriers and problems of the business are described. In the practical part this theory is applied to one specific company and the evaluation of the facts and a proposal of some possible options for improvement takes place at the end.
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Analysis of Business Environment
Horáková, Eva ; Rompotl, Jaroslav (referee) ; Breinek, Pavel (advisor)
This Bachelor thesis analyses the business environment. In the theoretical part the environment of the company, barriers and problems of the business are described. In the practical part this theory is applied to one specific company and the evaluation of the facts and a proposal of some possible options for improvement takes place at the end.
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Pre-processing of acquired data for system identification purposes
Horáková, Eva ; Chlápek, Petr (referee) ; Máša, Vítězslav (advisor)
The present bachelor’s thesis follows a methodology of data processing for the experimental system identification. Summarizes basic principles of experimental identification and describes a general methodology of experimental data processing. Next part of thesis attends to describing a building of compact data file, that contains selected variables including calculation of other important variables. Measurements to obtain experimental data was realized on real technology, which is a unit of biomass and phytomass combustion, power of unit is 1 MW. The work also includes selection and evaluation of appropriate intervals for an identification of this unit and their graphic presentation.
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Iron metabolism of parasitic amoeba Acanthamoeba castellanii
Krejbichová, Lucie ; Mach, Jan (advisor) ; Horáková, Eva (referee)
Acanthamoeba castellanii, an opportunistic parasitic amoeba, rarely causes infection in humans. Yet, the treatment and diagnosis is often complicated. It causes two diseases: granulomatous encephalitis and acanthamoeba keratitis (inflammation of the cornea of the eye). There is a modern way to deal with parasitic protists and other infectious diseases - interference with iron metabolism. Iron is a crucial element for living organisms; it is involved in many metabolic processes. However, it is also toxic for the organisms and therefore, its uptake, storage and homeostasis in the cell is a strictly controlled process. Ferric reductase takes part in iron homeostasis inside the acanthamoeba cell. Fluorescent microscopy has shown that ferric reductase is located in the vacuole membranes and its activity increases when iron availability decreases. This protein probably mediates the reduction of iron ions that are used in other cellular processes, especially for the transport of iron across membranes. Interestingly, the reduced availability of iron doesn't affect the mitochondrial Fe-S cluster pathway as we proved by fluorescent microscopy with an antibody against one of the proteins of this pathway (IscU). Iron deficiency doesn't affect respiration but alternative oxidase activity is reduced. Moreover, deprived...
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Voltammetric Determination of Genotoxic Nitrobiphenyls
Horáková, Eva ; Vyskočil, Vlastimil (advisor) ; Navrátil, Tomáš (referee)
The presented diploma thesis is devoted to study of determination of 4-nitrobiphenyl (4-NBP) in model river water by DC voltammetry (DCV) and differential pulse voltammetry (DPV) at m-AgSAE (diploma thesis relates to bachelor thesis, in it DCV and DPV methods for determination of 4-NBP in deionized water were developed). Limit of determination (LOD) is 2·10-7 mol·l-1 by DCV and 4·10-7 mol·l-1 by DPV. The adsorptive stripping DPV (AdSDPV) technique was tested to archive lower LOD the AdSDPV, optimal conditions were not found. Electrochemical behavior of 2-nitrobiphenyl (2-NBP) at m-AgSAE was studied. Optimal conditions for its determination by both techniques DCV and DPV were found in methanol-0,01 mol·l-1 LiOH (1:9) and in this medium peak current dependence in 1·10-7 mol·l-1 to 1·10-4 mol·l-1 2-NBP (LOD ≈ 2·10-7 mol·l-1 by DCV and 1·10-7 mol·l-1 by DPV) concentration range was measured. Developed methods were successfully tested for determination of 2-NBP in drinking and river water samples. For both mediums obtained LODs were 2·10-7 mol·l-1 by DCV and 1·10-7 mol·l-1 by DPV. AdSDPV technique was unsuccessfully tested to achieve lower LOD. Optimal conditions for simultaneous determination of 4-NBP and 2-NBP by DPV technique at m-AgSAE were found: methanol-0,25 mol·l-1 acetate buffer (pH = 6,0) 3:7....
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Mercury Electrodes as Tools for Voltammetric Determination of Biologically Active Organic Compounds and for Detection of Their Interaction with DNA
Horáková, Eva ; Vyskočil, Vlastimil (advisor) ; Ludvík, Jiří (referee) ; Vytřas, Karel (referee)
The main aim of this work was to use traditional mercury electrodes for the development of voltammetric methods of determination of organic xenobiotics and for the electrochemical study of the interaction between double-stranded deoxyribonucleic acid (DNA) and these compounds. In relation to my previous research work (conducted in the framework of my diploma thesis), firstly, 4-nitrobiphenyl (4-NBP), the suspected carcinogen, was studied. Interaction of DNA with 4-NBP was studied using differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronocoulometry at a hanging mercury drop electrode (HMDE), and using CV and alternating current voltammetry at a DNA modified HMDE. Using CV, the reduction mechanism was investigated. The interaction of DNA with 4-aminobiphenyl (4-ABP), a metabolite of 4-NBP, and 4-NBP reduction intermediates was studied. It was found that the interaction of DNA with 4-NBP or 4-ABP results in a formation of a DNA aggregate with these analytes. The second studied analyte was methyl violet 2B (MV). For determination of MV in a buffered solution were used: direct current tast polarography and differential pulse polarography at a dropping mercury electrode, and direct current voltammetry, DPV, and differential pulse adsorptive stripping voltammetry (DPAdSV) at HMDE. The...
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Maintaining dignity for patients in coma at ARO, ICU
Horáková, Eva ; Chloubová, Helena (advisor) ; Herbrichová, Andrea (referee)
This thesis deals with the saturation of the needs of patients in coma. The challenge was to find not only theoretical knowledge of respondents about the needs of man, but especially the higher saturation of psychosocial needs. Work deals with cultural, ethnic and religious diversity of patients and their influence on the patient's dignity. Especially in the health care problems and terminal care. It focuses on the most frequent nursing interventions, which cause disruption of intimacy and thus the stage and dying. In the research part, we try to confirm the objectives and hypotheses using quantitative research methods questionnaire. Quantitative results following qualitative research using observation of randomly selected nurses. From the research showed that nurses do not have sufficient theoretical knowledge of the theory of human needs, and therefore very rarely saturate other than physiological needs. Dignity of a sick person is impaired primarily in health care. Communication not only with the patient, but family is poor and annoying the nurses.
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