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Optimizing and Evaluating the Biocompatibility of Fiber Composites with CaP Additives
Suchý, Tomáš ; Sucharda, Zbyněk ; Balík, Karel ; Sochor, M. ; Bačáková, Lucie
Composite materials based on a polyamide fabric (aramid) and a polydymethyl-siloxane (PDMS) matrix were designed for application in bone surgery. In order to increase the bioactivity, 2, 5, 10, 15, 20 and 25 vol. % of nano/micro hydroxyapatite (HA) and tricalcium phosphate (TCP) were added. The effect of the additives on the biocompatibility was studied. It appears that nano additives have a more favorable effect than micro particles on mechanical properties. For final application of the composites as substitutes for bone tissues, 15 vol. % of nano hydroxyapatite additives is an optimum amount: in this case both the mechanical properties and the biological properties are optimized without distinct changes in the inner structure of the composite.
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Carbon nanoparticles as promising components of materials for bone tissue engineering
Grausová, Ľubica ; Bačáková, Lucie (advisor) ; Mikšík, Ivan (referee) ; Balík, Karel (referee)
Recently, nanotechnology in tissue engineering has become a very irnportant field of study. Many different materials of nanoscale roughness have been studied for their potential use in the regeneration of various tissues. The reason is that nallostructured materials imitate the architecture of natural extracellular matrix and thus support cell adhesion, growth and differentiation. Our investigations were focused on the influence of fullerene layers, carbon nanotube-terpolymer composites and nanocrystalline diamond layers on the adhesion. growth and differentiation of human osteoblast-like MG 63 cells. Each of these materials supported colonization with cells. On continuous fullerene C6s layers, deposited on composites with the carbon matrir reinforced with carbon fibres, the cell population density was lower than on non-coated composites. but MG 63 cells were well-spread w'ith rvell-developed vinculin-containing focal adhesiort plaques and a beta- actin cy'toskeleton. On contposites of carbon naliotubes u ith a terpolymer of poll.tetrafluoroethvlene. poly propy lene and polyvinyldifluoride, the adhesion, spreading. formation oť tbcal adhesion plaques and actin cytoskeleton, viability and cell grouth u ere markedly improved in comparison with pure terpolymer. At the same time, these cells did not...
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Particulate composites based on nano HA/TCP particles for bone graft replacements
Suchý, Tomáš ; Rýglová, Šárka ; Balík, Karel ; Sucharda, Zbyněk ; Denk, F.
Particulate composite materials have been developed for applications in the form of an intervertebral cage (for use in spine treatment). The intervertebral cage is composed of a bearing cage made of PEEK and a composite core with the surface contacting the bone surface and ensuring elastic linkage of two vertebral bodies, resulting in good adhesion to the bone. Mechanical analysis of different kinds of particulate composites was performed. The effect of hydroxyapatite and tri-calcium phosphate nanofiller volume fractions on the mechanical properties of particulate composites was investigated.
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Biocompatibility optimization of fabric composites by calcium phosphates
Sochor, M. ; Balík, Karel ; Suchý, Tomáš ; Sucharda, Zbyněk
Composite materials based on a polyamide fabric and a polydimethylsiloxane matrix were designed for application in bone surgery. In order to increase the bioactivity, 2, 5, 10, 15, 20 and 25 vol. % of nano/micro hydroxyapatite and tricalcium phosphate were added. The effect of the additives on the mechanical properties was studied. Simultaneously, changes in the inner structure of the composites were investigated by means of image analysis.
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Some surface improvement and osseointegration
Suchý, T. ; Balík, Karel ; Sedláček, R. ; Sochor, M.
As a further perspective material to be used in orthopedics, glass fibers (R-glass, 21055 satin-woven fabric, VETROTEX, Saint Gobain, France) and polysiloxane matrix (M130, Lučební závody Kolín, Czech Republic) based composite materials have been investigated.
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