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	Role of microbiota in mouse experimental model of psoriasis Jirásková Zákostelská, Zuzana ; Stehlíková, Zuzana ; Klimešová, Klára ; Rossmann, Pavel ; Dvořák, Jiří ; Novosádová, Iva ; Kostovčík, Martin ; Coufal, Štěpán ; Šrůtková, Dagmar ; Hudcovic, Tomáš ; Štěpánková, Renata ; Rob, F. ; Jůzlová, P. ; Herzogová, J. ; Tlaskalová-Hogenová, Helena ; Kverka, Miloslav Anotace v anglickém jazyce\n\nMouse model of human psoriasis and gnotobiotic are important tools in understanding the role of gut and skin microbiota in pathogenesis of psoriasis. In our experiments we showed that gnotobiotic mice, as well as conventional mice treated with antibiotics, have milder skin inflammation in comparison with control conventional mice. Treatment with broad spectrum antibiotics led to dramatic shift in gut microbial composition, in particular, we observed extensive increase of order Lactobacillales. To analyze the potential effect of Lactobacillales on skin inflammation, we further monocolonized mice with L. plantarum WCFS1. Also monocolonized mice showed lower skin inflammation in comparison with conventional mice. To understand whether microbial dysbiosis is cause or effect of psoriasis needs to be further investigated.\n\n Detailed record
	Gut microbiome and colorectal cancer Tlaskalová-Hogenová, Helena ; Klimešová, Klára ; Zákostelská, Zuzana ; Kverka, Miloslav ; Hornová, Michaela ; Vannucci, Luca ; Štěpánková, Renata ; Hudcovic, Tomáš ; Kozáková, Hana ; Rossmann, Pavel The work deals with metagenomic approaches that are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of microbiota on the host. Detailed record
	Vliv komensální mikroflóry na indukci slizniční tolerance k alergenu pylu břízy u BALB/c myší Kozáková, Hana ; Repa, A. ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Schwarzer, Martin ; Hudcovic, Tomáš ; Tlaskalová, Helena ; Wiedermann, U. Compared with germ-free mice model, the microflora has no effect on the development of allergic responses or the ability to induce tolerance using a clinical relevant allergen Detailed record
	Vliv rekombinantní bakterie Lactobacillus plantarum na vývoj pylové alergieL Schwarzer, Martin ; Repa, A. ; Wiedermann, U. ; Hrnčíř, Tomáš ; Daniel, C. ; Pot, B. ; Štěpánková, Renata ; Hudcovic, Tomáš ; Tlaskalová, Helena ; Součková, Martina ; Kozáková, Hana Germfree mice were monocolonized with recombinant Lactobacillus plantarum producing Bet v 1. Subsequently mice were sensitized by intraperitoneal injections to Bet v 1. We found out that monocolonization with recombinant L. plantarum reduced the level of specific Bet v 1 specific IgE antibody and stimulated production of INF-gamma in spleen cells supernatants. We conclude that monocolonization by recombinant L. plantarum shifts the immune response towards Th-1 direction and that it is a promising vaccine candidate against type I allergy Detailed record
	Imunologické aspekty rozvoje kolorektálního karcinomu na bezmikrobních modelech Vannucci, Luca ; Štěpánková, Renata ; Pospíšil, Miloslav ; Kozáková, Hana ; Tlaskalová, Helena ; Kuldová, Markéta ; Fišerová, Anna Our data support the finding that mild chronic inflammation sustained by commensal flora in the bowel of conventional animals may be the cause of an effective anticancer response by both mucosal and general immunity Detailed record
	Protective effect of E. coli strain Nissle 1917 and E. coli strain O83 on the development of inflammation in dextran sulphate sodium-induced colitis in mice Hudcovic, Tomáš ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Kozáková, Hana ; Schwarzer, Martin ; Tlaskalová, Helena The study was focused on the evaluation of probiotic bacteria E. coli strain Nissle 1917 and E. coli strain O83 and their role in the development of intestinal inflammation in DSS model of ulcerative colitis and the route of the application. Intragastrically tubing SCID mice ( with severe combined immunodeficiency) had heavy chages (inflammation) of the colon – part descendens. Intrarectally application had a protective effect on the development of intestinal inflammation – part colon descendens. Proinflammatory cytokines TNF – alpha and IL – 6 were reduce markedly in fragment culture from colon - descendens Detailed record
	Influence of germ-free conditions on the development of sensitization and tolerance to the main compound of brich pollen Bet v 1 in mice Kozáková, Hana ; Repa, A. ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Hudcovic, Tomáš ; Tlaskalová, Helena ; Pollak, A. ; Wiedermann, U. Birch pollen is one of the most frequent airborne allergen of Central and North Europe. The effect of intestinal microflora on sensitization and mucosal tolerance to main component of birch pollen Bet v 1 did not be study yet. Germ-free and conventional mice were administrated intragastrically or intranasally with Bet v 1 following by subcutaneous injections of Bet v 1. Tolerance was established independently on microflora present resulting decreased level of IgE and changed cytokine production Detailed record
	Vnímavost k navození nazální a orální tolerance je nezávislá na přítomnosti mikroflóry Repa, A. ; Kozáková, Hana ; Hudcovic, Tomáš ; Štěpánková, Renata ; Hrnčíř, Tomáš ; Tlaskalová, Helena ; Pollak, A. ; Wiedermann, U. The development of mucosal tolerance to major allergic component of birch pollen in relationship with presence of intestinal microflora was the aim of presented study. Germ-free (GF) or conventionally reared (CV) BALB/c mice were intragastrically or intranasally pre-treated with Bet v 1 prior to sensitization performed by subcutaneous injections of Bet v 1. Oral as well as intranasal tolerance induction led to a significant reduction of allergen-specific antibody levels and IgE basophil degranulation, as well as cytokine production in vitro in both GF and CV mice. The importance of the microflora for mucosal tolerance induction in GF mice remains therefore a matter of debate Detailed record
	Vliv střevních bakterií na vývoj kolitidy u SCID myší po přenosu CD4+CD45RB high T buněk a na změny těsných spojů (TJs) a Panetových buněk Štěpánková, Renata ; Powrie, F. ; Kofroňová, Olga ; Kozáková, Hana ; Hudcovic, Tomáš ; Hrnčíř, Tomáš ; Tlaskalová, Helena In the model of colitis developing in T cell reconstituted SCID mice pronounced morphological impairment of colon, was accompanied by structural changes of tight junctions and decreased expression of alpha defensins in terminal ileum Detailed record
	Vliv střevní mikroflóry na endotoxinový šok Hrnčíř, Tomáš ; Kobayashi, K. ; Flawell, R. A. ; Hudcovic, Tomáš ; Kozáková, Hana ; Štěpánková, Renata ; Tlaskalová, Helena Endotoxin shock is the most severe complication of sepsis. Lipopolysaccharide (LPS) or endotoxin, a structural component of gram negative bacteria, is a major effector and can activate the innate immune system and lead to multiple organ failure, termed endotoxin shock. In our project we study the effect of intestinal microflora on the susceptibility to endotoxin using a model of germ-free and specific pathogen free mice Detailed record

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