National Repository of Grey Literature 16 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Analysis of adherence to application technique in COPD patients
Jachanová, Klára ; Hendrychová, Tereza (advisor) ; Ťupová, Lenka (referee)
Analysis of adherence to application technique in COPD patients Author: Klára Jachanová Tutor: PharmDr. Tereza Hendrychová, Ph.D. Consultant: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Adherence is an sssential component of patient care and is also important for achieving treatment goals. Poor adherence leads to increased morbidity, mortality and healthcare expenditures. The aim of this study was to analyze adherence to application technique in patients with chronic obstructive pulmonary disease (COPD), taking into account inhaler device and patient characteristics. Methods: The Czech Multicenter Research Database of COPD, non-interventional observational prospective study, was used as a source of clinical data. Adherence to the application technique was evaluated using Five Steps Assessment. Patients were recruited to the study from August 2013 to December 2016 by 14 outpatient secondary health care centers providing respiratory physician- based care to patients with COPD throughout the Czech Republic. Each of the five consecutive steps was evaluated by a trained healthcare professional. The study evaluated dry powder inhaler and pressurised matered-dose inhaler. Physical and...
Nursing care of the respiratory system
LINHARTOVÁ, Vendula
The topic of this bachelor thesis is nursing care related to the respiratory system and its diseases. Acute or chronic forms of disease may occur in any hospital units and it is important to know basic rules, treatments and best practices of taking care of the respiratory system. The theoretical part is focused on breath monitoring, application of inhalation preparations, Oxygenotherapy and maintain patency of respiratory system. It also describes hospital units involved in practical research. Two objectives have been set for this thesis. First, how often are nurses at departments of Internal medicine, Surgery and Pneumology in touch with respiratory system diseases, which diseases cause most cases of hospitalization, how these nurses take care of respiratory system and their best practices related to Oxygenotherapy, measuring oxygen saturation and inhalation. Second, what kind of information about respiratory system diseases is known to hospitalized patients and how they care about themselves. Empirical part of this thesis was performed in qualitative form, using semi-structured interview. The questions were divided into six categories: (1) frequency of appearance of respiratory disease; (2) breath monitoring; (3) central oxygen supply system; (4) inhalation; (5) airway suction; (6) education. Research group contains nine nurses with different qualification levels from three distinct hospital units and nine patients with different diagnosis of respiratory disease. The research reveals that there are almost no cases of respiratory disease at department of Surgery. On other hand, nurses at department of Pneumology are in daily touch with respiratory diseases and hospitalized patients belong to the Old age category (65+). Nurses also hardly even use Oxymeter, only in case of Acute deterioration, but they have good enough skills and knowledge of treatment methods and are fully capable to take care of patients' respiratory system.
Sanatorium with speleotherapy for children in Ostrov u Macochy
Promna, Denisa ; Odvárka, Antonín (referee) ; Žalmanová, Petra (advisor)
The main idea was to choose a child as a measure of design. Immerse yourself in his world and his perception of space - keep in mind his needs. What did the place where he would be able to recover from respiratory problems look like? Was she in the hospital? What kind of room was that? What was that for? place? Did nature play any meaning in that? Would you like to go back there? How does she remember him? The aim was to create a place that resembles the hospital environment as little as possible, is in direct contact with nature and attracts to get to know it more. The stay in the hospital should be more reminiscent of spending holidays at school in nature. How to avoid austere hospital premises? Is there such a guide at all? Should I draw inspiration elsewhere? Where do we go to gain strength from everyday worries? In nature, of course. And how does this need translate into architecture? And we have at all such architecture? The answer to the questions I asked was the cottage. House created for a stay in nature. But how to lift it to something richer and more interesting? There was something else that fascinated me as a child spending time in Luhačovice - the spa environment. How these two forms to connect?
DNA damage induced by occupational exposure to copper oxide nanoparticles
Rössner st., Pavel ; Pelcová, D. ; Elzeinová, Fatima ; Mikuška, Pavel ; Večeřa, Zbyněk ; Coufalík, Pavel ; Vlčková, Š. ; Fenclová, Z. ; Rössnerová, Andrea
Copper oxide nanoparticles (CuO NPs) have a widespread use in industry, chemistry, in production of electronic devices and as an antimicrobial agent. Although copper is an important biogenic element, CuO NPs are toxic with the ability to induce oxidative stress, apoptosis, cell cycle arrest or DNA damage. For humans, the inhalation route is the most common way of exposure to CuO NPs. In the body, CuO NPs may be either deposited in the lungs, or transported to other organs. Their presence usually causes oxidative stress or inflammatory responses, consequently leading to DNA damage. In this study, we investigated the effect of CuO NPs inhalation on DNA damage in a group of researches conducting animal exposure experiments. The subjects were exposed to various metal oxide nanoparticles, including CuO NPs, by inhalation for an average of 4.9 ± 0.4 years. The average mass concentration of Cu in the air during the experiment was 7.3 ± 3.2 ng/m3. Subjects not exposed to nanoparticles served as a control group. We applied micronucleus assay using Human Pan Centromeric probes to detect DNA damage and to distinguish between the frequency of centromere positive (CEN+) and centromere negative (CEN−) micronuclei (MN) in the binucleated cells. We\ndid not find differences between both groups for either mean MN frequency (10.38 ± 2.50 vs. 11.88 ± 3.01 MN/1000 binucleated cells), or CEN+/CEN- ratio (58%/42% vs. 55%/45%), for the exposed and controls, respectively. In conclusion, inhalation of CuO NPs at this low-level exposure had no effect on chromosomal losses and/or breaks.
Verification of hyperoxia influence on performance in the team sprint modified for SkiErg
Schützová, Sandra ; Suchý, Jiří (advisor) ; Gnad, Tomáš (referee)
Title: Verification of the effects of hyperoxia on the result in a test simulating performance in a team sprint on SkiErg skiing simulator. Objectives: The work aims to verify the effect of hyperoxia on the result in a test simulating performance in a team sprint on SkiErg skiing simulator. Methods: This is a qualitative research conducted by comparing hart rate, power in watts and lactate in ten probands. Values measured after inhalation of concentrated oxygen and placebo were compared. Results: There was no positive effect from meansurements of the heart rate, power in watts and lactate after concentration of inhaled oxygen and placebo on the SkiErg simulator. We concluded that the effect of inhalated concentrated oxygen Was in our test statistically insignificant. Keywords: Cross-country skiing, strengh, hyperoxia, heart rate, lactate
Exposure to Nanoparticles in Work Environment
Köbölová, Klaudia ; Mikuška, Pavel (referee) ; Adamec, Vladimír (advisor)
Outside to the wide range of potential benefits, the use of nanomaterials can endanger human health and the environment. This diploma thesis presents the results of pilot measurements, where the exposure of nanoparticles was monitored. Based on a literature research a suitable method for measurement was the three-stage OECD model. Based on this model, measurements were performed in three welding workplaces, where nanoparticles are produced incidentally. The measurement consisted of collecting information and measuring the concentration of nanoparticles in the workplace, where data collection was focused only on inhalation exposure. During welding, 0.3 m size particles are produced and their concentration is strongly influenced by the welding material, type of welding and suction. The particles are amorphous in terms of morphology and contain manganese, iron and silicon, which can cause neurodegenerative diseases. Furthermore, the results indicate the importance of monitoring oral exposure.
GENE EXPRESSION AND IMMUNOLOGICAL RESPONSE IN MICE EXPOSED TO ZnO NANOPARTICLES
Rössner ml., Pavel ; Vrbová, Kristýna ; Strapáčová, S. ; Rössnerová, Andrea ; Ambrož, Antonín ; Brzicová, Táňa ; Líbalová, Helena ; Javorková, Eliška ; Zajícová, Alena ; Holáň, Vladimír ; Kulich, P. ; Večeřa, Zbyněk ; Mikuška, Pavel ; Coufalík, Pavel ; Křůmal, Kamil ; Čapka, Lukáš ; Dočekal, Bohumil ; Šerý, Omar ; Machala, M. ; Topinka, Jan
We analyzed gene expression changes in the lungs and the immunological response in splenocytes of mice exposed by inhalation of ZnO nanoparticles - NP. Adult female ICR mice were treated for three days and three months, respectively. Analysis of differential expression in genes involved in oxidative stress was conducted using quantitative RT-PCR. The potential immunotoxic and immunomodulatory effects of ZnO NP were analyzed by phenotyping and cytokine production by splenocytes after three months exposure. Three days exposure resulted in down-regulation of GCLC, GSR, HMOX-1, NQO-1, NF-kB2, PTGS2 and TXNRD1 mRNA expression, three months exposure increased the expression of these genes. Three months exposure caused a significant decrease in the percentage of granulocytes in the spleen cells, and affected the production of IL-10 and IL-6 by lipopolysaccharide-stimulated leukocytes. In summary, our study revealed changes in the expression of genes involved in the oxidative stress response following acute ZnO NP exposure. Subchronic ZnO NP exposure induced immunomodulatory effects in the spleen.
Effect of inhaled metal oxide nanoparticles on organs of exposed mice
Mikuška, Pavel ; Večeřa, Zbyněk ; Dočekal, Bohumil ; Čapka, Lukáš ; Křůmal, Kamil ; Coufalík, Pavel ; Moravec, Pavel ; Buchtová, Marcela ; Míšek, Ivan ; Vrlíková, Lucie ; Smutná, Tereza ; Dumková, J. ; Hampl, A. ; Fictum, P.
Adult mice were continuously exposed to metal oxide nanoparticles for different time intervals. At the end of experiment, mice organs (lung, brain, kidney, liver and spleen) were collected for chemical, biochemical, histological and electron microscopical analyses.
Old - new urban spa
Hrušková, Ludmila ; Šindlar, Jiljí (referee) ; Hrabec, Josef (advisor)
The bachelor thesis deals with the town spa in Zábrdovice by architect Bohuslav Fuchs. Spaces were inserted into the spa, which did not burden their construction with their functions. The urbanistic study deals with the Zábrdovice area, which will become the Military Campus.
Study of organs of mice in inhalation experiments
Vrlíková, Lucie ; Diviš, Pavel (referee) ; Dočekal, Bohumil (advisor)
The diploma thesis is devoted to study potential risks for living organisms resulting from inhalation of nanoparticles of chosen heavy metals. The main aim of this work is the investigation of organs from experimental white mice after their guided inhalation of lead nanoparticles. The samples of liver and lungs from these animals are taken in time periods during the inhalation experiments and processed by specific methods for their evaluation. After pressurized microwave assisted decomposition of selected samples of mice organs in high purity concentrated nitric acid the content of lead is determined by atomic absorption spectrometry with electrothermal atomization. Furthermore, the changes are monitored using the microscopy of histological slides stained with hematoxylin-eosin. The results of both approaches are evaluated and compared within the frame of this work.

National Repository of Grey Literature : 16 records found   1 - 10next  jump to record:
Interested in being notified about new results for this query?
Subscribe to the RSS feed.