Národní úložiště šedé literatury Nalezeno 3 záznamů.  Hledání trvalo 0.02 vteřin. 
Deformation response of polydimethylsiloxane substrates subjected to uniaxial quasi-static loading
Vinařský, V. ; Martino, F. ; Forte, G. ; Šleichrt, Jan ; Rada, Václav ; Kytýř, Daniel
To investigate cellular response of cardiomyocytes to substrate mechanics, biocompatible material with stiffness in physiological range is needed. PDMS based material is used for construction of microfluidic organ on chip devices for cell culture due to ease of device preparation, bonding, and possibility of surface functionalization. However it has stiffness orders of magnitude out of physiological range. Therefore, we adapted recently available protocol aiming to prepare substrates which offer stiffness in physiological range 5−100 kPa using various mixtures of Sylgard. An in-house developer loading device with single micron position tracking accuracy and sub-micron position sensitivity was adapted for this experimental campaign. All batches of the samples were subjected to uniaxial loading. During quasi-static experiment the samples were compressed to minimally 40% deformation. The results are represented in the form of stress-strain curves calculated from the acquired force and displacement data and elastic moduli are estimated.
Multi-channel control system for in-situ laboratory loading devices
Rada, Václav ; Fíla, Tomáš ; Zlámal, Petr ; Kytýř, Daniel ; Koudelka_ml., P.
In recent years, open-source applications have replaced proprietary software in many fields. Especially open-source software tools based on Linux operating system have wide range of utilization. In terms of CNC solutions, an open-source system LinuxCNC can be used. However, the LinuxCNC control software and the graphical user interface (GUI) could be developed only on top of Hardware Abstraction Layer. Nevertheless, the LinuxCNC community provided Python Interface, which allows for controlling CNC machine using Python programming language, therefore whole control software can be developed in Python. The paper focuses on a development of a multi-process control software mainly for in-house developed loading devices operated at our institute. The software tool is based on the LinuxCNC Python Interface and Qt framework, which gives the software an ability to be modular and effectively adapted for various devices.
Influence of printing and loading direction on mechanical response in 3D printed models of human trabecular bone
Doktor, Tomáš ; Kumpová, Ivana ; Wroński, S. ; Śniechowski, M. ; Tarasiuk, J. ; Forte, G. ; Kytýř, Daniel
The paper deals with investigation on directional variations of mechanical response in 3D printed models of human trabecular bone. Sample of trabecular bone tissue was resected from human donor and 3D model was obtained by X-ray computed tomography. Then a series of cubical samples was prepared by additive manufacturing technique and tested by uniaxial compression loading mode. Mechanical response was compared in nine different combinations of direction of 3D printing and loading direction. The results show neglectible influence on the deformation response in elastic region (stiffness) and significant changes of the behaviour in plastic region (stress and strain at yield point, strain at full collapse).

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