National Repository of Grey Literature 32 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Attitudes and beliefs on HPV infection and vaccination
Blašková, Dominika ; Zimčíková, Eva (advisor) ; Pokladníková, Jitka (referee)
ATTITUDES AND KNOWLEDGE OF HPV INFECTION AND VACCINATION Author: Dominika Blašková Supervisor: PharmDr. Eva Zimčíková, Ph.D. INTRODUCTION Human papillomavirus (HPV) is a DNA virus. The virus causes benign and malignant diseases of men and women such as laryngeal papillomatosis, genital warts, oropharyngeal carcinoma, cervical cancer, penile cancer and anus cancer. HPV can be prevented by appropriate precautionary measures. The main preventative method is vaccination against HPV. Besides vaccination, regular screening is necessary to detect premalignant changes on time. AIMS The aim of the theoretical part of the diploma thesis was to summarize the information about HPV, the diseases caused by human papillomavirus and vaccination against HPV, the main preventive measure. The primary aim of the practical part was to find out the level of HPV awareness among girls and boys and diseases caused by HPV. The secondary aim of the practical part was to find out opinions on HPV vaccination and determine the rate of vaccination against HPV among young people in Slovakia. METHODS The method of quantitative research taken in the form of a questionnaire was used in the diploma thesis. The survey was realized at two secondary schools in Svidník, Slovakia. The age range of respondents was 15-20 years. The data...
Analysis of Anticoagulant Utilization in the Czech Republic in the period from 2007 to 2016
Hochelová, Zuzana ; Zimčíková, Eva (advisor) ; Malý, Josef (referee)
Analysis of anticoagulant utilization in the Czech republic in the period from 2007 to 2016 Author: Zuzana Hochelová1 Supervisor: PharmDr. Eva Zimčíková, Ph.D.1 Consultant: PharmDr. Kateřina Malá, Ph.D.1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Anticoagulants are drugs that reduce blood clotting and prevent the formation of blood clots. In the Czech Republic - antagonists of vitamin K-warfarin, direct oral inhibitors of factor Xa-rivaroxaban, apixaban, edoxaban, direct oral inhibitors trombin - dabigatran, parenteral anticoagulants - heparin, low-molecular heparin, fondaparinux, oral and parenteral hirudin are used. Objective: The objective of this diploma thesis was to assess the consumption of oral and parenteral anticoagulants in the Czech Republic from 01. 01. 2007 to 31. 12. 2016, based on the data from the State Institute of Drug Control (SIDC). Methods: ATC/DDD methodology was applied. The research consisted of a retrospective analysis of the SIDC database. All oral and parental anticoagulants approved in the CR were included in the study. Drug utilization was calculated as number of defined daily doses per thousands of inhabitants per day (DID). The data on the number of residents was acquired from...
Pharmacovigilance: Drug regulation development and legislation overview.
Manišová, Michaela ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Mgr. Michaela Manišová Consultant PharmDr. Jan Kostřiba, Ph.D. Title of Thesis Pharmacovigilance: Drug regulation development and legislation overview. Introduction: Pharmacovigilance is a scientific discipline relating to the detection and evaluation of adverse drug reactions and other risks associated with the use of the medicinal products after marketing authorisation and implementation of the risk minimisation measures. Objectives: To analyze the legislation requirements in the area of pharmacovigilance for the medicinal products for human use in the European Union and their implementation in practice. Trends in adverse drug reactions reporting in the various pharmacovigilance systems (United States, Czech Republic, European Union), evaluation of the factors affecting reporting and the main benefits of spontaneous reporting. Methods: The legal requirements of the European Union, the Czech Republic and the United States was used as the source of information, followed by the official website of the Drug Regulatory Authorities, the best practices guidelines prepared by the European Medicines Agency and by the Food and Drug Administration, the harmonization guidelines issued by...
Analysis of Pharmacy Economy in the Hradec Králové Region
Lepšová, Nikol ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of: Social and Clinical Pharmacy Author: Nikol Švorcová Supervisor: PharmDr. Jan Kostřiba, Ph.D. Title of Diploma Thesis: Analysis of Pharmacy Economy in the Hradec Kralove Region Introduction: The economy of pharmacies in the Czech republic is currently being discussed topic mainly due to the growth pharmacies belonging to chains. Within a few years there have been many highly discussed changes that have changed the pharmacy market and its character. Large companies, which operates a lot of pharmacies was established and these companies quickly increase number of their pharmacies. This has led to the emergence of so-called virtual chains, which help many private entrepreneurs in this area to maintain competitiveness. Between 2008 and 2015 was economy of pharmacies influenced by regulatory fees. The biggest problem of last years is the closure of pharmacies in smaller municipalities, which reduces the availability of pharmaceutical care. The Ministry of Health and the Czech Chamber of Pharmacists are finding a solution to these problems. Objectives: The aim of this diploma thesis is to evaluate the total financial health of selected pharmacies of the Hradec Kralove Region using methods of financial analysis based on a calculation...
MenB vaccine uptake and number of reported cases with MenB infection
Švédová, Monika ; Zimčíková, Eva (advisor) ; Marešová, Helena (referee)
MenB vaccine uptake and number of reported cases with MenB infection Author: Monika Švédová Supervisor: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Meningococcal disease caused by Neisseria meningitidis is global issue and it's known for its epidemical potential. In Europe, this disease is most often caused by B and C serotype. Main aim was to track occurence and other epidemiologic aspects related to invasive meningococcal disease (IMD) in the Czech Republic from 2007 to 2016, focusing on serotype B and summarize available vaccinations which are used to fight disease mentioned above. Another was to analyse usage of Bexsero vaccination in the Czech Republic, hand in hand with number of spontaneous reports of adverse events after vaccination. Methodology: To assess epidemiologic aspects related to IMD data from the Centre of epidemiology and microbiology were used (years 2007 - 2016). Vaccination utilization was analysed based on data from the State Institue of Drug Control and expressed as number of packages. Central database of spontaneous adverse events reports was used to determine number and character of reports. Results: In period 2007-2016 there was a decrease in meningococcal disease...
Pharmacovigilance of active substance zolpidem
Vorel, Roman ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Social and Clinical Pharmacy Author: Roman Vorel Supervisor: PharmDr. Jan Kostřiba, Ph.D. Title of Diploma Thesis: Pharmacovigilance of active substance zolpidem Introduction: Drug safety became very important topic in the second half of 20th century, even beyond pharmacy. It relates to increasing impact on testing of drugs before launch onto the market, but also following monitoring, so the benefit and risk ratio of drug can be determined. Pharmacovigilance takes care of monitoring of drug use risk. Zolpidem is active substance from class hypnotics and it is used for short-term treatment of insomnia. Most professionals recommend zolpidem as first line treatment of acute insomnia. That is why it can be considered as one of the most important hypnotic drugs. Objectives: The aim of this diploma thesis is to analyze spontaneous reports for adverse drug reaction for zolpidem from years 2004 to 2017. The thesis focus on reports from the Czech republic but also from the whole world. The information in SPC of medicinal products containing zolpidem which were distributed from 2004 to 2017 are compared. Methods: Following data from years 2004 to 2017 were used: 1) List of spontaneous reports for adverse reaction from the Czech republic...
Evaluation of the rationality of prescribing in the old age (III.)
Hrdličková, Petra ; Fialová, Daniela (advisor) ; Zimčíková, Eva (referee)
Introduction During the last decades, proportion of geriatric patients in the world population increases. This phenonemon is caused particularly by advances in medical science, social care and working conditions. However, the problem still lies in a very frequent polypharmacotherapy and polymorbidity in older patients. With the aim to reduce the frequent adverse drug events in seniors, the explicite criteria of PIMs (potentially inappropriate medications) have been created. The aim of this work was to determine the registration rates of PIMs in several Eastern and Central European countries using all until now published 22 explicit criteria of potentially inappropriate medications in older patients that are available in published scientific literature. Methods A set of 345 PIMs gained from all explicit criteria published in peer- reviewed or impact factor journals by 2015 year and summarized in diploma thesis of S . Grešákové, MSc (defended in June 2016) was used in this work. Every drug has been included in the list only once, disregarding the other conditions of inappropriateness (e.g. drug-disease interactions, dosing schedules, etc.). The exception were PIMs available in non-sustained and sustained-release forms, because each of this drug form can be identified under a specific ATC code....
Use of inhaled drugs in obstructive pulmonary diseases
Obertová, Nikola ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Use of inhaled drugs in obstructive pulmonary diseases Author: Nikola Obertová 1 Tutor: Josef Malý 1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objectives: Chronic respiratory diseases are emerging health problem. The administration of the medication is mostly performed by the process of inhalation. Therefore, a proper inhalation technique plays a crucial role in symptom reduction and achievement of adequate control over the disease. The aim of the thesis was partly to assess the level of inhalation technique in elderly patients in nursing home settings, partly to evaluate the knowledge of nurses and their role in advice provision related to the proper inhalation technique. Methods: The data were collected from June to September 2016 from 18 nursing homes located in South Wales (Great Britain). The study was realized in two arms. The evaluated group (first arm) was composed of patients (residents) with having asthma bronchiale or chronic obstructive pulmonary disease diagnosed and being older than 65 years. Second arm consisted of nurses responsible for giving advices about inhalation technique to the residents. Nursing home visits were composed of three parts. First one was a controlled interview based on the...
Analysis of drug-related problems in a health facility IV.
Šubrtová, Linda ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of drug-related problems in a health facility IV. Author: Linda Šubrtová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Increasing use of drugs leads to a growing risk of occurence of drug-related problems. These problems can often endanger patient's health and increase the economic cost of the treatment. However, many of these problems can be prevented by controls and collaboration of all health care subjects. Objective: The aim of this work was to carry out a revision of pharmacotherapy in a rehabilitation health facility and to analyse acquired drug-related problems. Methodology: The collection of data took place from 13 to 15 February 2017 in health facility in the Czech Republic. The review of pharmacotherapy was performed by a three-member team (clinical pharmacist, pharmacist, work researcher). The data obtained from the provided medical records were recorded into the database, which was prepared for the purpose of the pharmacotherapy review. Recorded were: the patient's age and sex, allergic, family, work, social and personal history, physical and laboratory examinations and complete pharmacotherapy, which included over-the-counter drugs and dietary supplements, including dosage...
Attitudes and beliefs on HPV infection and vaccination II
Regnerová, Veronika ; Zimčíková, Eva (advisor) ; Malá, Kateřina (referee)
Attitudes and beliefs on HPV infection and vaccination II Veronika Regnerová, PharmDr. Eva Zimčíková, Ph.D. Background: Cervical cancer is the second most common type of cancer in women. The majority of cervical cancer cases are caused by human papillomavirus (HPV). Three vaccines have been approved to prevent HPV infection and related diseases. Objectives: The study aimed to analyse the knowledge and attitudes regarding HPV, cervical cancer and HPV vaccination in secondary school students in the Czech Republic. Methods: The study was carried out in May 2017 at four secondary schools. A questionnaire used for data collection comprised 15 items including questions on demographic characteristics, knowledge about cervical cancer and HPV, vaccination coverage, HPV perceived susceptibility and seriousness, and beliefs on HVP vaccination. Results: A total of 667 students participated (mean age: 16.8 y ± 1.18; 63% female); 20.5% were smokers, 24.7% God believers. Most of the students (97.0%) heard about cervical cancer and penile cancer, significant proportion (68.3%) knew HPV was the causative factor. Half of the respondents (49.9%) have heard about vaccination against HPV. Among cervical cancer risk factors HPV infection was reported in 58.1% cases followed by promiscuity (14.5%), irregular...

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