National Repository of Grey Literature 69 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Influence of crystalloid and colloid solutions on blood coagulation using the rotational thromboelastometry (ROTEM) method
Binterová, Silvie ; Durila, Miroslav (advisor) ; Vaněk, Tomáš (referee) ; Bláha, Jan (referee)
Fluid resuscitation with crystalloid and colloid solutions is a common treatment in perioperative medicine. However, a variety of unbalanced or balanced solutions is used in clinical practice and there is still a vivid debate going on regarding the selection of optimal fluid with minimal negative effect on coagulation. The goal of the dissertation was to investigate the adverse effect of balanced crystalloids and colloids on whole blood coagulation measured by method of rotational thromboelastometry. In the first phase of the work we had assessed the adverse effect of balanced crystalloid, hydroxyethyl starch and gelatin after dilution of blood with the solution in vitro. Parametrs of EXTEM and FIBTEM tests were evaluated by using rotational thromboelastometry. In the second phase of the work we evaluated the negative effect of infusion solution after dilution in vivo. We had obtained blood samples from 30 patients during knee arthroscopy before and after administration of 500 ml of crystalloid or hydroxyethyl starch or gelatin. Parametrs of EXTEM and FIBTEM tests were evaluated by using rotational thromboelastometry.In compliance with the results of the dissertation, hydroxyethyl starch has the most obvious negative effect on clot formation followed by gelatin and finally by crystalloids. Based on...
Aortocoronary bypass surgery with or without heartlung machine in high risk patients.
Hlavička, Jan ; Vaněk, Tomáš (advisor) ; Vojáček, Jan (referee) ; Rohn, Vilém (referee)
This dissertation entitled "Aortocoronary bypass surgery with or without heart-lung machine in high risk patients" is a summary of the findings of two published works by the author: Off-pump Versus On-Pump Coronary Artery Bypass Grafting Surgery in High-Risk Patients: PRAGUE-6 Trial at 30 Days and 1 Year, published in the journal Biomedical Papers in 2015 and Aspirin is insufficient in inhibition of platelet aggregation and thromboxane formation early after coronary artery bypass surgery, published in Journal of Thrombosis and Thrombolysis in 2009. The PRAGUE-6 study, which focused exclusively on patients with very high operative risk according to the EuroSCORE scoring system, confirmed the hypothesis of a higher incidence of combined endpoints up to the 30th day among patients operated with extracorporeal circulation, particularly acute myocardial infarctions. This significant difference was not maintained after one year after the surgery, mainly due to the increase in mortality between the 30th day and the 1st year in patients operated off-pump. The dissertation further discusses similar papers published on the topic in recent years, including the two very last meta- analyzes. The second part of the thesis follows the topic of myocardial revascularization in the field of antiaggregation therapy...
Postoperative delirium in patients after cardiac surgery
Vlk, Robert ; Suchopárová, Štěpánka (advisor) ; Vaněk, Tomáš (referee)
UNIVERZITA KARLOVA V PRAZE 3. LÉKAŘSKÁ FAKULTA Ústav ošetřovatelství Robert Vlk Pooperační delirium u pacientů po kardiochirurgickém výkonu Postoperative delirium in patients after cardiac surgery Bakalářská práce Praha, červen 2018 1 Abstract The aim of this research is to find the predisposing factors of postoperative delirium in cardiac surgery patients, especially due to the use of extracorporeal circulation during cardiac surgery. The delirium itself causes prolongation of the hospitalization of the patient, increases the cost of treatment, and may further endanger the patient's health or life. Delirium also puts higher demands on the medical and nursing care provided to the patient. The ground for the research are 652 patients who were treated in 2016 at the Department of Cardiac Surgery, 3rd Faculty of Medicine, Charles University in Prague, University Hospital Kralovske Vinohrady, Prague. Depending on the occurrence of postoperative delirium, they are divided into two groups. By determining the level of statistical significance, it is determined how the individual factors are important for predicting the occurrence of postoperative delirium. Quite surprising is the finding that the use of extracorporeal circulation alone is not associated with an increased risk of post-operative delirium. However,...
Current Possibilities in Use of a Centrifugal Pump in the Cardiac Sugery
Mlejnský, František ; Lindner, Jaroslav (advisor) ; Lonský, Vladimír (referee) ; Vaněk, Tomáš (referee)
Current Possibilities in Use of a Centrifugal Pump in the Cardiac Sugery Abstract Currently, the most commonly used technical solution for pumping blood during extracorporeal circulation during cardiac surgery, as well as for some types of ECMO (extracorporeal membrane oxygenation) are either a roller pump or centrifugal pump. Due to its advantages the centrifugal pump is mainly used for prolonged extracorporeal circulation in cardiac surgery and as a heart and / or lung support system. In current literature there is a lack of compelling scientific evidence that would clearly support its use in a routine cardiac surgery. The aim of our study was to compare both types of currently used blood pumps in longer cardiac procedures with deep hypothermic circulation arrest. In a randomized clinical study we had selected a group of patients that underwent a pulmonary endarterectomy (PEA) in order to demonstrate the positive effects of the centrifugal pump on the postoperative inflammatory reactions. There were no statistically significant differences between these two pumps when other clinical and laboratory parameters were observed. Based on the hypothesis that significant temperature changes during cardiac procedure with a deep hypothermia can affect sealing pressure of the endotracheal tube cuff, we performed a...
Fibrinolysis in cardiac surgery and possibillity of its control
Špegár, Ján ; Vaněk, Tomáš (advisor) ; Cvachovec, Karel (referee) ; Stříteský, Martin (referee)
Local and systemic application of tranexamic acid in heart valve surgery: a prospective, randomized, double blind LOST study SUMMARY The study was performed to examine a possible augmentation of systemic administration of tranexamic acid by the additional topical application during heart valve surgery in the post-aprotinin era. One-hundred patients were enrolled in the study and all the patients were given tranexamic acid intravenously. The participants were randomized into two groups (A, n = 49; B, n = 51), and before commencing the sternal suturing, the study solution (group A: 250 ml of normal saline + tranexamic acid 2.5 g, placebo group B: 250 ml of normal saline) was poured into the pericardial cavity. The cumulative blood loss (geometric means [95% confidence intervals]) 4 h after the surgery was 86.1 [56.1, 132.2] ml in group A, and 135.4 [94.3, 194.4] in group B, test for equality of geometric means P = 0.107, test for equality of variances P = 0.059. Eight hours after the surgery, the blood loss was 199.4 [153.4, 259.2] ml in group A, 261.7 [205.1, 334.0] ml in group B, P = 0.130 and P = 0.050, respectively. Twentyfour hours postoperatively the blood loss was 504.2 [436.0, 583.0] ml in group A, 569.7 [476.0, 681.7] ml in group B, P = 0.293 and P = 0.014, respectively. The proportion of patients...

National Repository of Grey Literature : 69 records found   1 - 10nextend  jump to record:
Interested in being notified about new results for this query?
Subscribe to the RSS feed.