National Repository of Grey Literature 75 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Novel binding proteins derived from small protein domains targeting diagnostically important molecules
Vaňková, Lucie ; Malý, Petr (advisor) ; Brynda, Jiří (referee) ; Trefil, Pavel (referee)
The rapid development of the gene engineering techniques, especially methods for in vitro directed evolution and combinatorial mutagenesis, has triggered the generation of new binding agents to almost any antigen of interest as an alternative to broadly used antibodies. These so-called non-Ig scaffolds are often derived from proteins with useful biophysical properties. While the therapeutic market is still dominated by monoclonal antibodies, the easy option of desired customization of non-Ig binders by conventional methods of gene engineering predestine them largely for the use in the diagnostic area. The ABD scaffold, derived from a three-helix bundle of albumin-binding domain of streptococcal protein G, represents one of the small non-Ig scaffolds. In our laboratory, we have established a highly complex combinatorial library developed on the ABD scaffold. This ABD scaffold-derived library was used to generate unique binders of human prostate cancer (PCa) biomarkers PSP94, KLK2, KLK11 for the more precise diagnosis of PCa. The second part of the thesis describes the generation of ABD-derived binders selectively recognizing different phenotypes of circulating tumor cells as a binding component of the cell capture zone of microfluidic chip for lung adenocarcinoma diagnosis. Beside this already...
Economic analysis of building optimization
Pospíchalová, Barbora ; Zelníčková, Aneta (referee) ; Vaňková, Lucie (advisor)
The Master’s thesis deals with the energy savings of a prefabricated house. In the theoretical part, the issue of investment and risk management are first dealt with. Afterwards, the thesis deals with large panel construction in the Czech Republic, energy performance of buildings, heat losses, and especially methods for invesment appraisal. The main objective of the thesis is the economic analysis and the life-cycle analysis. The case study deals with the calculation of saving on heating the prefabricated house after its refurbishment and calculation of economic indicators.
Investment Risk Management of Construction Project
Pluháčková, Darinka ; Vaňková, Lucie (referee) ; Korytárová, Jana (advisor)
The goal of this paper is to evaluate economic efficiency of a development project, including sensitivity and probability analysis of selected residential development project. In theoretical part, the term "development project" is explained and project lifecycle is described. In this part there is also mentioned, how cash flow is determined, how cash flow report is created, and how economic efficiency indicators are calculated. It also describes specific risks of a development project. In the end of theoretical part, possible risk identification and evaluation methods are described. Practical part is focused on an actual development project. It evaluates the project using economic efficiency indicators, sensitivity analysis and probability analysis.
Management of municipal property
Marek, Martin ; Vaňková, Lucie (referee) ; Vítková, Eva (advisor)
This master thesis deals with management of municipality property municipality Stará Turá in the years 2013 - 2018. The theoretical part defines the territorial self-government in the Slovak republic, as well as management of the municipality, budget revenues and budget expenditures and municipality property. The analytical part contains basic information about the village Stará Turá, analysis and subsequent management of municipality property in the years. The last part deals with the possible utilization of the economic result for improvement of the municipality of Stará Turá.
Evaluation of economic efficiency of business project
Burianová, Denisa ; Vaňková, Lucie (referee) ; Kocourková, Gabriela (advisor)
The thesis concems about investments and their effectiveness. The goal of the thesis is to find out whether it is worth to make the investment. The project deals with the reconstruction of a public cultural house in which three new apartments are build into. Cost of reconstruction, rental rates will be quantified and then mortage loan will be determined. This information wil be used for further calculations and the result will be an evaluation of the investment. The result of this work is to determine if the investment is really effective.
Territory development strategy in relation to construction production
Mecová, Anna ; Chovancová, Jitka (referee) ; Vaňková, Lucie (advisor)
This diploma thesis deals with comparison of regions of the Czech Republic between national economy in terms of construction production and selection of region with the greatest potential for development of construction production. In the theoretical part is defined the term region, which is followed by regional economics and politics. Another topic addressed is regional development territorial development strategies and indicators that capture the differences between regions. The practical part deals with the characteristics of the national economy and construction in individual regions, which is folloved by a draft strategy dealing with problems in the field of construction. The last part of the thesis, regions are compared according to the given indicators and the regions with the greatest potential for the development of construction production are indentified.
Effectiveness of the process of valuation of construction production
Sofka, Filip ; Vaňková, Lucie (referee) ; Krejza, Zdeněk (advisor)
Diplomová práce se zabývá efektivitou oceňování stavební výroby. Teoretická část se věnuje oceňování stavební výroby, analýzou náročnosti oceňování, principem sestavení rozpočtů a představení BIM procesu ve stavebnictví. Praktická část se věnuje konkrétnímu způsobu zefektivnění oceňování stavební výroby. Efektivita je zkoumána ve fázi zpracování výkazu výměr, pomocí BIM modelů a porovnána s CAD modelem. Výsledkem je definování možné úspory zpracování výkazu výměr pomocí BIM modelu. Závěrečná část je věnována popisu standardizace stavebnictví.
Proposal for alternative financing of the reconstruction of the square in Třebíč
Hykolli, Nikolas ; Černá, Marie (referee) ; Vaňková, Lucie (advisor)
The diploma thesis deals with the proposal of a possible way of financing the reconstruction of Charles Square in Třebíč and choosing the optimal variant. The theoretical part summarizes all important concepts related to the theme of the diploma thesis. These include public administration in the Czech Republic, central and local budget systems, selection procedures and funding sources. In the practical part are found the ways of financing the urban investment, both own and foreign. These may include credits and grant titles.
Specifics of real estate market in the Olomouc region
Suk, Ondřej ; Krejza, Zdeněk (referee) ; Vaňková, Lucie (advisor)
The objective of the thesis Specifics of real estate market in the Olomouc region is to analyse the real estate market of the districts of the Olomouc region. Then compare the market specifics of these districts and compare the selected location within the Czech Republic. The first part of the thesis is focused on the theoretical description and terms related to the real estate market. Then it describes the subjects of the real estate market and the factors that influence this market. Next chapter is focused on the regional policy and its impact on the real estate market. In the next part is the analysis of real estate market in the Olomouc region itself. There is the comparison of the districts in the Olomouc region. The analysis is focused mainly on the price development of selected types of real estate in the selected location and then is compared within the Czech Republic.
Analysis of the process of liquidation of damage events of buildings
Osmanová, Sára ; Vaňková, Lucie (referee) ; Krejza, Zdeněk (advisor)
This thesis is focused mainly on the liquidation process of damage events related to the buildings. The analysis of the whole process and recommendations for limiting of individual risk is involved. Within the insurance discurs, asset insurance is characterized by a new price and the time prize. This difference is described in the practical part of the thesis, where the partial damages caused by the storm on the family house and the overall damage to the cottage after a major fire accident. At the end of the case study, an assessment of the most serious insurance risks is described.

National Repository of Grey Literature : 75 records found   1 - 10nextend  jump to record:
See also: similar author names
14 VAŇKOVÁ, Lenka
18 VAŇKOVÁ, Lucie
14 Vaňková, Lenka
1 Vaňková, Leona
1 Vaňková, Linda
1 Vaňková, Ludmila
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