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The role of state governance in GVCs - the example of the globalization of the Czech automotive industry after the 1990s
 Tian, Yu ; Svoboda, Karel (vedoucí práce) ; Nigrin, Tomáš (oponent)
The dynamics of governance is one of the most active topics of debate in the GVC and global production network debate, yet attention on the subject of governance has been largely focused on TNCs, with less attention paid to the state and public governance aspects. In recent studies, the role of the state in GVC governance has received more attention, and following in-depth analyses some scholars have proposed three key governance functions: facilitative, regulatory and distributive. Against this background, this paper will analyze the history of the Czech automotive industry in the development of GVCs after 1990 and the role of the state in the automotive industry's participation in GVCs based on the theory of the three roles of the state in GVC governance: facilitator, regulator and distributor. Keywords National governance; global value chains; global production networks; Czech cars; political economy; privatisation
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Novel conformationally locked nucleosides and nucleotides
 Nencka, Radim ; Šála, Michal ; Hřebabecký, Hubert ; Procházková, Eliška ; Mackman, R. ; Barauskas, O. ; Lee, Y. J. ; Tian, Y.
We report on a synthesis of two novel types of conformationally locked nucleoside analogues. We prepared 7 membered ring 3’,5’-bridged nucleoside analogs locked in a Southern conformation. These nucleoside analogues were converted in one pot to appropriate phosphoramidate prodrugs using boronate methodology. We also devised and prepared a novel carbocyclic nucleoside by replacing furanose with cyclohexene that resulted in a locked Northern conformation similar to LNA monomers. Further details on the biological activity and application for oligonucleotide synthesis will be discussed in detail.
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